Decreased pain tolerance and mood in recreational users of MDMA
PsychopharmacologyPublished 30 January 2004
Margaret Claire O’Regan, Angela Clow
Citations18
SJR quartileQ1
SJR score1.16
SNIP0.97
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TL;DR
The current results suggest that MDMA, at least in the short term, may cause serotonin-mediated alterations in pain sensitivity, and confirmed the association between MDMA and depressed mood.
Abstract
This study found an association between pain tolerance and MDMA usage and confirmed the association between MDMA and depressed mood. The current results suggest that MDMA, at least in the short term, may cause serotonin-mediated alterations in pain sensitivity.
Keywords
PsychologyMedicinePharmacology, Toxicology and Pharmaceutics
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Journal of Clinical NeurophysiologyNeuroanatomy of the Pain System and of the Pathways That Modulate Pain
901 Citations1997William D. Willis, Karin N. Westlund
Structures involved in the descending analgesia systems, including the periaqueductal gray, locus ceruleus, and parabrachial area, nucleus raphe magnus, reticular formation, anterior pretectal nucleus, thalamus and cerebral cortex, and several components of the limbic system are described and the pathways and neurotransmitters utilized are mentioned.
British Journal of AddictionRecreational MDMA use in Sydney: a profile of ‘Ecstasy’ users and their experiences with the drug
417 Citations1992Nadia Solowij, Wayne Hall +1 more
The research revealed that Ecstasy is primarily used by infrequent recreational drug users for 'fun' at dance parties and social gatherings and tolerance was reported to develop to the positive effects of Ecstasy, while negative effects increased with use.
PsychopharmacologyReview of the pharmacology and clinical pharmacology of 3,4-methylenedioxymethamphetamine (MDMA or “Ecstasy”)
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Human Psychopharmacology Clinical and ExperimentalHuman psychopharmacology of Ecstasy (MDMA): a review of 15 years of empirical research
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Abstinent regular Ecstasy users often display reduced levels of 5‐HT, 5‐HIAA, tryptophan hydroxylase and serotonin transporter density; functional deficits in learning/memory, higher cognitive processing, sleep, appetite and psychiatric well‐being, and, most paradoxically, ‘loss of sexual interest/pleasure’.
PsychopharmacologyEcstasy (MDMA) effects upon mood and cognition: before, during and after a Saturday night dance
344 Citations1998A. C. Parrott, Julian J. Lasky
The cognitive deficits in drug-free recreational ecstasy users, suggest that MDMA may also be neurotoxic in humans, and agrees with previous findings of memory impairments indrug-free ecstasy users.
NeuropsychopharmacologySerotonin Neurotoxicity after (±)3,4-Methylenedioxymethamphetamine (MDMA; “Ecstasy”): A Controlled Study in Humans
335 Citations1994Una D. McCann, Alison Ridenour +2 more
Differences in personality support the view that 5-HT systems are involved in modulating impulsive and aggressive personality traits and suggest that5-HT neurotoxicity may be a potential complication of MDMA use.
AddictionMood and cognitive effects of ± 3,4‐methylenedioxymethamphetamine (MDMA, ‘ecstasy’): week‐end ‘high’ followed by mid‐week low
283 Citations1997H. Valerie Curran, Ross A. Travill
Weekend use of MDMA may lead to depressed mood mid-week, and possible mechanisms underlying the findings are discussed in terms of temporary depletion of serotonin, serotonergic neurotoxity and psychological aspects of mood change.
Journal of Pharmacology and Experimental TherapeuticsLasting effects of (+-)-3,4-methylenedioxymethamphetamine (MDMA) on central serotonergic neurons in nonhuman primates: neurochemical observations.
270 Citations1992G.A. Ricaurte, Alessandra Martello +2 more
The results suggest that MDMA produces lasting effects on serotonergic neurons in nonhuman primates, with most brain regions showing evidence of persistent denervation and some showing signs of reinnervation (thalamus or possibly even hyperinnervation) and the morphological and functional correlates of these enduring neurochemical changes in the MDMA-treated primate remain to be delineated.
Journal of NeuroscienceReorganization of ascending 5-HT axon projections in animals previously exposed to the recreational drug (+/-)3,4-methylenedioxymethamphetamine (MDMA, "ecstasy")
269 Citations1995Christina Weide Fischer, George Hatzidimitriou +3 more
Examination of 5-HT innervation patterns in animals lesioned with MDMA suggests that, under some circumstances, MDMA injury can lead to a lasting reorganization of ascending 5- HT axon projections.
Brain ResearchRelative contributions of the nucleus raphe magnus and adjacent medullary reticular formation to the inhibition by stimulation in the periaqueductal gray of a spinal nociceptive reflex in the pentobarbital-anesthetized rat
264 Citations1984Jürgen Sandkühler, Gerald F. Gebhart
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Annals of MedicineEvidence-based data on pain relief with antidepressants
259 Citations2000David A. Fishbain
Evidence indicated that antidepressants could be effective for pain associated with some specific pain syndromes, such as chronic low back pain, osteoarthritis or rheumatoid arthritis, fibrositis or fibromyalgia, and ulcer healing.
Brain ResearchToxic effects of MDMA on central serotonergic neurons in the primate: importance of route and frequency of drug administration
249 Citations1988G.A. Ricaurte, L.E. DeLanney +2 more
This study compared the toxic effects of oral versus subcutaneous and single versus multiple doses of 3,4-methylenedioxymethamphetamine (MDMA) on central serotonergic neurons in non-human primates to suggest that humans using MDMA may be at risk for incurring central Serotonergic neuronal damage.
PsychopharmacologyThe relative contributions of ecstasy and cannabis to cognitive impairment
227 Citations2000Rodney J. Croft, Alexander Mackay +2 more
The results suggest that cannabis is an important confound in studies of MDMA-related cognitive impairment, and that previously reported cognitive impairment in MDMA users may have been caused by coincident cannabis use.
Drug and Alcohol DependenceMDMA (`ecstasy') consumption in the context of polydrug abuse: a report on 150 patients
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NeuropsychobiologyIs MDMA (‘Ecstasy’) Neurotoxic in Humans? An Overview of Evidence and of Methodological Problems in Research
143 Citations2000H. Valerie Curran
Evidence from research with a range of animal species, from rodents to non-human primates, has shown that MDMA (±3,4-methylenedioxymethamphetamine) is neurotoxic, and three types of research are overviewed: neurobiological, psychological/somatic and psychiatric.
Human Psychopharmacology Clinical and ExperimentalEcstasy (MDMA) in Recreational Users: Self-Reported Psychological and Physiological Effects
135 Citations1997D. DAVISON, A. C. Parrott
Although regular users all described their first MDMA experience as ‘the most intense’, later trips were affected by knowledge and expectancy, rather than any diminution in drug response, which may help explain the low addiction potential of MDMA.
European Journal of Pharmacology(±)-3,4-Methylenedioxymethamphetamine (MDMA, ‘Ecstasy’) increases social interaction in rats
111 Citations2000Kirsten C. Morley, Iain S. McGregor
Integrative Psychological and Behavioral SciencePain perception to the cold pressor test during the menstrual cycle in relation to estrogen levels and a comparison with men
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The results showed that men tolerated significantly greater pain than women and women’s pain threshold was significantly higher during the second phase of the menstrual cycle, while systolic pressure was higher in men than women, increasing more in men in response to cold pressor testing than women.
Brain Research5-Hydroxyindoleacetic acid in cerebrospinal fluid reflects serotonergic damage induced by 3,4-methylenedioxymethamphetamine in CNS of non-human primates
89 Citations1988G.A. Ricaurte, L.E. DeLanney +3 more
CSF 5-HIAA can be employed to detect central serotonergic damage produced by MDMA in non-human primates, and it is suggested that CSF may be useful for detecting MDMA-induced neuronal damage in humans.
Pharmacology Biochemistry and BehaviorThe Anxiogenic-Like and Anxiolytic-Like Effects of MDMA on Mice in the Elevated Plus-Maze A Comparison With Amphetamine
85 Citations1999Huangbin Lin
The results indicate that MDMA has anxiogenic-like properties at lower doses and anxiolytic-like at higher doses, providing a possible explanation for the controversies over MDMA's effects on anxiety in the literature.
Journal of Substance AbuseExperimentally induced aggressive behavior in subjects with 3,4-methylenedioxy-methamphetamine (“Ecstasy”) use history
56 Citations2001Gilberto Gerra, Amir Zaimovic +7 more
The findings suggest that Ecstasy users have higher outward-directed aggressiveness than healthy subjects, and increased catecholamines reactivity, basal hypothalamus-pituitary-adrenal (HPA) axis hyperactivity, and blunted ACTH responses could be due to MDMA action on monoaminergic pathways and adrenal function.
Pharmacological ResearchMDMA (‘ecstasy’) exhibits an anxiogenic-like activity in social encounters between male mice
49 Citations2001E. Maldonado, José Francisco Navarro
MDMA produced a behavioural pattern characterized by a marked decrease of aggression as well as social investigation, body care and digging behaviours, without affecting immobility, which might indicate that MDMA has anxiogenic-like properties in male mice.
Progress in Neuro-Psychopharmacology and Biological PsychiatryDifferential behavioural and neurochemical effects of para-methoxyamphetamine and 3,4-methylenedioxymethamphetamine in the rat
47 Citations2000Lynette C. Daws, Rodney J. Irvine +4 more
Data suggest that the acute adverse effects of PMA are more likely to be associated with alterations in serotonergic rather than dopaminergic neurotransmission.
Progress in Neuro-Psychopharmacology and Biological PsychiatryEffects of 3,4-methylenedioxy-methamphetamine (MDMA) on anxiety in mice tested in the light-dark box
47 Citations2000E. Maldonado, José Francisco Navarro
The behavioral profile found in the light/dark test indicates an anxiogenic-like activity of MDMA in mice, and it is suggested that animal models of anxiety which emphasize a social interaction could be more sensitive to the effects of this substance.
European Journal of PharmacologyAcute and carryover effects in mice of MDMA (“ecstasy”) administration during periadolescence
28 Citations2002Sara Morley‐Fletcher, Mauro Bianchi +2 more
Results indicate a differential long-term vulnerability to behavioural and neurotoxicant effects of MDMA as a function of the developmental stage of exposure in mice treated chronically with MDMA during middle and late adolescence.
Current Opinion in PsychiatryEcstasy (3,4-methylenedioxymethamphetamine)
26 Citations1993Nadia Solowij
Human Psychopharmacology Clinical and ExperimentalEcstasy (MDMA), amphetamine, and LSD: comparative mood profiles in recreational polydrug users
24 Citations1997A. C. Parrott, Marta Stuart
MDMA's mood profile was more unique, with significantly higher feelings of elation, agreeableness and composure, than the other two drugs.
Neuropsychobiologychronic pain: hypothesized mechanism and rationale for treatment
23 Citations2008Samuel Gershon
The rationale for the current hypothesis, including psychopharmacology and the role of serotonin reuptake blockers, will be reviewed.
Neurochemistry InternationalAcute effects of 3,4-methylenedioxymethamphetamine on brain serotonin synthesis in the dog studied by positron emission tomography
19 Citations1999S Nishisawa
The influence of an acute dose of 3,4-methylenedioxymethamphetamine (MDMA; Ecstasy) on the brain serotonin synthesis in the dog was assessed using alpha [11C]methyl-L-tryptophan and positron emission tomography.
Pharmacology Biochemistry and BehaviorThe antinociceptive effects of 3,4-methylenedioxymethamphetamine (MDMA) in the rat
12 Citations1989Terriann Crisp, Janet L. Stafinsky +2 more
It is suggested that the antinociceptive effects of MDMA are serotonergically mediated, and the results verify earlier findings describing the test-specific effects of serotonin-induced pain modulation.
PubMedBasic concepts of pain and pain therapy.
9 Citations1984Marco Zimmermann
Pain originating in the peripheral nervous system is based on the excitation of nociceptor excitability, which are contained among A-delta- and C-fibers from skin, viscera, joints and muscles, which is thought to be a mechanism of peripheral analgesia.