Highly Enantioselective Catalytic Fluorination and Chlorination Reactions of Carbonyl Compounds Capable of Two‐Point Binding
Angewandte Chemie International EditionPublished 8 June 2005Open access
Norio Shibata, Junji Kohno, Kazumi Takai, Takehisa Ishimaru, Shuichi Nakamura, Takeshi Toru
Citations327
SJR quartileQ1
SJR score5.55
SNIP2.47
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Abstract
New tools in drug development: The catalytic enantioselective fluorination and chlorination reactions of carbonyl compounds containing an additional binding site (see scheme) proceed with extremely high enantioselectivity and require low catalyst loadings (2–10 mol % dbfox-Ph/NiII). Asymmetric amplification is also observed in these enantioselective halogenations.
Keywords
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