Double-blind comparison of zopiclone and flunitrazepam in elderly insomniacs with special focus on residual effects
Current Medical Research and OpinionPublished 1 January 1995
Ove Dehlin, Brian G. Rubin, Å Rundgren
Citations20
SJR quartileQ2
SJR score0.79
SNIP0.76
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
In a double-blind study of 102 patients with a mean age of 79 years, zopiclone was compared to flunitrazepam and there were no differences between the drugs as regards patients' feelings of being rested or alertness.
Abstract
In a double-blind study of 102 patients with a mean age of 79 years, zopiclone was compared to flunitrazepam. The patients rated their sleep in a diary. There was no statistically significant difference between the relatively low dose of 5 mg zopiclone and 1 mg flunitrazepam for eleven out of the twelve variables measuring subjective sleep quality and quantity. There was no differences between the drugs as regards patients' feelings of being rested or alertness.
Keywords
PsychologyNeuroscience
Journal of Psychiatric Research“Mini-mental state”
86,858 Citations1975Marshal F. Folstein, Susan E. Folstein +1 more
A simplified, scored form of the cognitive mental status examination, the “Mini-Mental State” (MMS) which includes eleven questions, requires only 5-10 min to administer, and is therefore practical to use serially and routinely.
International PsychogeriatricsMental Disorders and the Use of Psychotropic Drugs in an 85-Year-Old Urban Population
123 Citations1993Ingmar Skoog, Lars Nilsson +2 more
The prevalence of mental disorders was studied in a representative sample of 85-year-old living in Gothenburg, Sweden, and the prescription of psychotropic drugs was high, only one fifth of those with depressive disorders received antidepressant drug therapy and one tenth ofThose with psychotic disorders received neuroleptics.
Drugs & AgingZopiclone
79 Citations1993Alison N. Wadworth, Donna McTavish
With its short duration of action and good tolerability profile, zopiclone is a well established alternative to the benzodiazepine hypnotics and may be particularly beneficial in those patients unable or unwilling to tolerate the residual effects associated with many other hypnotic agents.
PubMedResidual effects of zopiclone and benzodiazepine hypnotics on psychomotor performance related to car driving.
46 Citations1985C. Harrison, Zahed Subhan +1 more
A double-blind, randomized, cross-over study was carried out in 10 normal healthy volunteers to investigate the residual effects of night-time medication on hypnotic efficacy of zopiclone, triazolam and flunitrazepam.
NeuropsychobiologyEffects of Zopiclone and Benzodiazepine Hypnotics on Search in Short-Term Memory
43 Citations2008Zahed Subhan, Ian Hindmarch
The effects of zopiclone, flunitrazepam and triazolam were found to be located in the serial comparison and response-selection organization stages of the reaction process although both fl unitrazep am and trizolam caused additional impairment of stimulus encoding.
SLEEPCritical Factors for Pharmacokinetics of Zopiclone in the Elderly and in Patients with Liver and Renal Insufficiency
32 Citations1987J. Gaillot, Y. Le Roux +2 more
On the basis of these findings, a reduction of the initial zopiclone dose from 7.5 to 3.5 mg/day is recommended for patients with severe liver insufficiency and patients over 70 years of age with liver Insufficiency.
Human Psychopharmacology Clinical and ExperimentalPerformance and mood following partial sleep deprivation: A randomized, double‐blind crossover study of zopiclone, triazolam, flunitrazepam, ethanol and placebo
19 Citations1988E Wickström, O. B. Godtlibsen +2 more
The overall assessment for sleep onset latency and subjective alertness indicated that zopiclone 7.5 mg and triazolam 0.25 mg had a more appropriate profile than the other drugs and doses tested.
PharmacologyA Comparative Study of Zopiclone and Flunitrazepam in Insomniacs Seen by General Practitioners
17 Citations2008E. Wickstr oslash m, S.E. Barbo +5 more
A double-blind crossover trial was conducted in 42 outpatients of either sex in order to obtain information on the properties of 7.5 mg of zopiclone in a general practice setting compared with 2 mg of flunitrazepam, and a comparison of the effect of the drugs showed a significant difference with regard to effectiveness and sleep latency.