Characterization of the analgesic activity of ketorolac in mice
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TL;DR
The spectrum of analgesic activity of ketorolac tromethamine was evaluated with mice exposed to the hot-plate, tail-flick and writhing tests and it was suggested that ketorlac might act in part by causing the release of endogenous opioids.
Abstract
The spectrum of analgesic activity of ketorolac tromethamine was evaluated with mice exposed to the hot-plate, tail-flick and writhing tests. Morphine and indomethacin were used as representative opioid and non-steroidal analgesics respectively. Ketorolac in doses of 5 or 7.5 mg/kg i.p. was active as an analgesic in all three of the procedures. In each case, naloxone (0.5 mg/kg i.p.) significantly decreased the analgesic activity of ketorolac. It was suggested that ketorolac might act in part by causing the release of endogenous opioids.