Origin and interstate spread of a New York City multidrug-resistant Mycobacterium tuberculosis clone family
JAMAPublished 14 February 1996
Pablo Bifani
Citations359
SJR quartileQ1
SJR score5.35
SNIP10.71
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TL;DR
The results document the molecular origin and spread of progeny of a closely related family of multidrug-resistant M tuberculosis strains that have recently shared a common ancestor and undergone clonal expansion.
Abstract
The results document the molecular origin and spread of progeny of a closely related family of multidrug-resistant M tuberculosis strains that have recently shared a common ancestor and undergone clonal expansion. The multidrug-resistant phenotype in these organisms arose by sequential acquisition of resistance-conferring mutations in several genes, most likely as a consequence of antibiotic selection of randomly occurring mutants in concert with inadequately treated infections. Dissemination of these difficult-to-treat bacteria throughout New York City and to at least four additional US cities has adverse implications for tuberculosis control in the 21st century.
Keywords
Medicine
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