Mechanical hyperalgesia in complex regional pain syndrome: A role for TNF-α?
NeurologyPublished 26 July 2005
Christian Maihöfner, Hermann O. Handwerker, B. Neundörfer, Frank Birklein
Citations111
SJR quartileQ1
SJR score2.40
SNIP1.82
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TL;DR
It is suggested that involvement of TNF-α in mechanical hyperalgesia of CRPS may be connected with higher levels of sTNF-RI.
Abstract
Plasma concentrations of soluble tumor necrosis factor alpha (TNF-alpha) receptor type I (sTNF-RI) were assessed in two complex regional pain syndrome (CRPS) patient groups (n = 30 and n = 16) and healthy controls (n = 25). Patients with CRPS and mechanical hyperalgesia had higher levels of sTNF-RI (1,661.8 +/- 146.8 pg/mL) compared with those with CRPS with identical clinical appearance but without hyperalgesia (1,155.9 +/- 56.3 pg/mL) and controls (1,239.5 +/- 42.9 pg/mL). This study suggests involvement of TNF-alpha in mechanical hyperalgesia of CRPS.
Keywords
Medicine
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