The crystal structure of the bacterial chaperonln GroEL at 2.8 Å
NaturePublished 1 October 1994
K. Braig, Zbyszek Otwinowski, Rashmi S. Hegde, D.C. Boisvert, A. Joachimiak, Arthur L. Horwich
Citations1,329
SJR quartileQ1
SJR score18.29
SNIP10.16
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TL;DR
The crystal structure of Escherichia coli GroEL shows a porous cylinder of 14 subunits made of two nearly 7-fold rotationally symmetrical rings stacked back-to-back with dyad symmetry.
Abstract
The crystal structure of Escherichia coli GroEL shows a porous cylinder of 14 subunits made of two nearly 7-fold rotationally symmetrical rings stacked back-to-back with dyad symmetry. The subunits consist of three domains: a large equatorial domain that forms the foundation of the assembly at its waist and holds the rings together; a large loosely structured apical domain that forms the ends of the cylinder; and a small slender intermediate domain that connects the two, creating side windows. The three-dimensional structure places most of the mutationally defined functional sites on the channel walls and its outward invaginations, and at the ends of the cylinder.
Keywords
Materials ScienceBiochemistry, Genetics and Molecular Biology
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