Factors determining serum-insulin response in a population sample
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TL;DR
An independent association of increasing age with increasing serum-insulin is evident at 50 years and over and provides strong support for the biological significance of serum-immunoreactive insulin.
Abstract
Serum-insulin levels were measured in 1770 subjects one hour after a 50 g glucose load. Multiple regression analyses reveal that a substantial proportion of the variability of log10 serum-insulin can be attributed to significant independent effect of blood-sugar, age, the food-interval, sex, parameters of body size, and scserum uric acid. Females have significantly higher levels of serum-insulin than males “One-hour” blood-sugar levels exceeding 160 nag/100 ml are associated with declining insulin levels. An independent association of increasing age with increasing serum-insulin is evident at 50 years and over. The findings provide strong support for the biological significance of serum-immunoreactive insulin.