Comparative efficacy of selective serotonin reuptake inhibitors and tricyclics in the treatment of melancholia
American Journal of PsychiatryPublished 1 December 1994
S P Roose, A H Glassman, Evelyn Attia, S. Woodring
Citations289
SJR quartileQ1
SJR score5.27
SNIP3.68
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
Fluoxetine appears to be significantly less effective than nortriptyline for treating hospitalized elderly patients with unipolar major affective disorder, especially those with the melancholic subtype and concurrent cardiovascular disease.
Abstract
Fluoxetine appears to be significantly less effective than nortriptyline for treating hospitalized elderly patients with unipolar major affective disorder, especially those with the melancholic subtype and concurrent cardiovascular disease.
Keywords
MedicineNeuroscience
Journal of Affective DisordersParoxetine: A selective serotonin reuptake inhibitor showing better tolerance, but weaker antidepressant effect than clomipramine in a controlled multicenter study
399 Citations1990Danish University Antidepressant Group
Categorical response measures and group averages of rating scores showed a significantly better therapeutic effect of clomipramine from the second week of treatment on, but generally at variance with the literature on this class of antidepressants, which, however, mostly deals with outpatient studies.
American Journal of PsychiatryThe pharmacological treatment of delusional depression
360 Citations1985Duane G. Spiker, Judy Weiss +7 more
The authors investigated the pharmacological treatment of delusional depression by assigning patients on a random double-blind basis to amitriptyline alone, perphenazine alone, or a combination of the two.
Archives of General PsychiatryAntidepressant Specificity in Atypical Depression
350 Citations1988Michael R. Liebowitz
The concept of atypical depression as a subtype that is preferentially responsive to monoamine oxidase inhibitors is supported and the superiority of either phenelzine or imipramine to placebo is supported.
Archives of General PsychiatryA Preliminary, Open Study of the Combination of Fluoxetine and Desipramine for Rapid Treatment of Major Depression
294 Citations1991J. Craig Nelson
Treatment with both desipramine and fluoxetine is a rapid and effective strategy for treatment of major depression, and supports recent hypotheses of noradrenergic-serotonergic synergism.
Archives of General PsychiatryPhenelzine v Imipramine in Atypical Depression
260 Citations1984Michael R. Liebowitz
Phenelzine was superior to placebo on many measures, while the superiority of imipramine to placebo was confined to several variables, and trends toward superiority on several other measures.
JAMAThe Safety of Tricyclic Antidepressants in Cardiac Patients
223 Citations1993Alexander H. Glassman
Until recently, it was the belief that depressed patients with preexisting arrhythmias would benefit from the antiarrhythmic effect of TCAs, but recent studies indicate that this opinion may need to be revised.
Archives of General PsychiatryDelusional Unipolar Depression
196 Citations1978J. Craig Nelson
The response of 13 delusional unipolar depressives to combination antipsychotic-tricyclic antidepressant drug therapy contrasts sharply with the low response rate described for delusional depressives when treated with tricyclic antidepressants alone.
JAMAThe Use of Imipramine in Depressed Patients With Congestive Heart Failure
120 Citations1983Alexander H. Glassman
The effect of imipramine hydrochloride on LVP, assessed by radionuclide angiography, in a group of depressed patients with notable preexisting left ventricular dysfunction is reported.
American Journal of PsychiatryTricyclic nonresponders: phenomenology and treatment
99 Citations1986Steven P. Roose, Alexander H. Glassman +2 more
The authors reviewed the records of inpatients with unipolar, nondelusional depression who had received adequate treatment with tricyclics and found that the nonresponders tended to have more previous episodes of depression and higher anxiety scores on the pretreatment Hamilton scale than the responders.
Journal of Clinical PsychopharmacologyCardiovascular Effects of Imipramine and Bupropion in Depressed Patients with Congestive Heart Failure
84 Citations1987Steven P. Roose, Alexander H. Glassman +4 more
Bupropion is a new antidepressant of the aminoketone class which is structurally unrelated to the tricyclics and which is relatively free of cardiac side effects in healthy depressed patients and may offer a safe alternative to imipramine in depressed patients with congestive heart failure.
Journal of Clinical PsychopharmacologyAntidepressant Drug Studies, 1964 to 1986
69 Citations1988Sylvia Gerson, D A Plotkin +1 more
The results of the survey support clinical experience: the drugs are clearly superior to placebo; they show comparable therapeutic efficacy and the choice of drug is based on side effects profiles and potential drug-drug interactions rather than on degree of therapeutic efficacy.
JAMANortriptyline in Depressed Patients With Left Ventricular Impairment
67 Citations1986Steven P. Roose
Nortriptyline emerges as a relatively safe treatment for depression in patients with left ventricular impairment and could be safely extended to patients with congestive failure.