An Evaluation of Ethamivan as a Respiratory Stimulant in Barbiturate Intoxication, and Alveolar Hypoventilation in Emphysema and Obesity

The role of respiratory stimulants in the management of acute respiratory failure due to barbiturate intoxication or chronic respiratory disease due to pulmonary disease is a subject of controversy.

Abstract

Article1 April 1964An Evaluation of Ethamivan as a Respiratory Stimulant in Barbiturate Intoxication, and Alveolar Hypoventilation in Emphysema and ObesityR. M. CHERNIACK, M.D., F.R.C.P.(C), F.A.C.P., G. YOUNG, M.D.R. M. CHERNIACK, M.D., F.R.C.P.(C), F.A.C.P.Search for more papers by this author, G. YOUNG, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-60-4-631 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe role of respiratory stimulants in the management of acute respiratory failure due to barbiturate intoxication or chronic respiratory failure due to pulmonary disease is a subject of considerable debate. While some investigators claim that analeptics are of little use in the management of barbiturate intoxication (1), others have recently stated that ethamivan (Emivan®), a central nervous system stimulant, is valuable (2-4). Similarly, it has been reported to be beneficial in chronic respiratory failure by some authors (5, 6), while less impressive results have also been reported (7).This paper presents an attempt to evaluate the effect of ethamivan in...References1. NILSSON E: On treatment of barbiturate poisoning. Acta Med. Scand. Supp. 253: 1127, 1951. Google Scholar2. SILIPOHAGEDORNROSENSTEINBAUM SCINGL: Experiences with ethamivan, a new respiratory stimulant and analeptic agent. JAMA 177: 122, 1961. CrossrefGoogle Scholar3. WHEELDONPERRY PJAW: The use of ethamivan in the treatment of barbiturate poisoning. Canad. Med. Ass. J. 89: 20, 1963. MedlineGoogle Scholar4. LOCKETT S: Vanillic acid diethylamide. Brit. Med. J. 2: 1805, 1960. CrossrefMedlineGoogle Scholar5. SAIDBANERJEE SICM: Effects of a newer respiratory stimulant (vanillic diethylamide) in respiratory acidosis due to obstructive pulmonary emphysema or obesity. Amer. J. Med. 33: 845, 1962. CrossrefMedlineGoogle Scholar6. MILLERARCHERTAYLOROSSENFORT WFRKHFWF: Severe respiratory depression: role of a respiratory stimulant, ethamivan in the treatment. JAMA 180: 905, 1962. CrossrefMedlineGoogle Scholar7. RODMANFENNELLYKROFTCLOSE TJFAJHT: Effect of ethamivan on alveolar ventilation in patients with chronic lung disease. New Eng. J. Med. 267: 1279, 1962. CrossrefMedlineGoogle Scholar8. ASTRUPSCHRÖDER PS: Apparatus for anaerobic determination of pH of blood at 38° C. Scand. J. Clin. Lab. Invest. 8: 30, 1956. CrossrefMedlineGoogle Scholar9. BRINKMANJOHNSDONOSORILEY GLCJHRL: A modification of the method of Riley, Proemmel and Franke for determination of oxygen and carbon dioxide tensions in blood. J. Appl. Physiol. 7: 340, 1954. CrossrefMedlineGoogle Scholar10. RILEYPROEMMELFRANKE RLDDRE: A direct method for determination of oxygen and carbon dioxide tensions in blood. J. Biol. Chem. 161: 621, 1945. CrossrefMedlineGoogle Scholar11. SCHOLANDER PF: Analyzer for accurate estimation of respiratory gases in one-half cubic centimeter samples. J. Biol. Chem. 167: 235, 1947. CrossrefMedlineGoogle Scholar12. CHERNIACK RM: The oxygen consumption and efficiency of the respiratory muscles in health and emphysema. J. Clin. Invest. 38: 494, 1959. CrossrefMedlineGoogle Scholar13. CAMPBELLWESTLAKECHERNIACK EJEKRM: Simple methods of estimating oxygen consumption and efficiency of the muscles of breathing. J. Appl. Physiol. 11: 303, 1957. CrossrefMedlineGoogle Scholar14. RILEY RL: The work of breathing and its relation to respiratory acidosis. Ann. Intern. Med. 41: 172, 1954. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: R. M. CHERNIACK, M.D., F.R.C.P.(C), F.A.C.P.; G. YOUNG, M.D.Affiliations: Winnipeg, Manitoba,From the Department of Medicine, University of Manitoba, and the Respiratory Division of the Clinical Investigation Unit, Winnipeg General Hospital, Winnipeg, Manitoba, Canada.This work was supported in part by grants from the Medical Research Council of Canada and The American Cyanamid Company, New York, New York.Requests for reprints should be addressed to R. M. Cherniack, M.D., Director, Cardio-Respiratory Division, Clinical Investigation Unit, Winnipeg General Hospital, 700 William Avenue, Winnipeg 3, Manitoba, Canada.*American Cyanamid Company, New York, New York. 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MERRILL, M.D.Nikethamide and Aminophylline in Ventilatory FailureVentilatory FailureExtreme Obesity with Respiratory Failure, Necessitating Artificial VentilationTHE MANAGEMENT OF RESPIRATORY FAILURE IN CHRONIC OBSTRUCTIVE LUNG DISEASEBLOOD GASES IN RESPIRATORY FAILURE STATE ON ADMISSION TO HOSPITAL AND MANAGEMENT 1 April 1964Volume 60, Issue 4Page: 631-640KeywordsComaEmphysemaHospital medicineIntoxicationObesityOverweightPartial pressure of carbon dioxidePartial pressure of oxygenPulmonary diseasesRespiratory failure ePublished: 1 December 2008 Issue Published: 1 April 1964 PDF downloadLoading ...