North of England evidence based guidelines development project: summary version of evidence based guideline for the primary care management of asthma in adults: Fig 1
BMJPublished 23 March 1996Open access
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Medicine
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The LancetCONTROLLED EVALUATION OF THE EFFECTS OF PATIENT EDUCATION ON ASTHMA MORBIDITY IN GENERAL PRACTICE
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ThoraxComparison of fluticasone propionate with beclomethasone dipropionate in moderate to severe asthma treated for one year. International Study Group.
187 Citations1993Leonardo M. Fabbri, Sherwood Burge +5 more
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182 Citations1993Ronald E. Dahl, Bo Lundbäck +5 more
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181 Citations1992MG Britton, JS Earnshaw +1 more
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BMJReducing hospital admission through computer supported education for asthma patients
179 Citations1994Liesl M. Osman, M Abdalla +6 more
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160 Citations1993NC Barnes, Gianni Marone +4 more
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155 Citations1982J.H. Toogood, J. Baskerville +3 more
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153 Citations1989Bernard Higgins, John Britton +5 more
Two variability indices, standard deviation percent mean and amplitude percent mean, provided the greatest separation between subjects with both a diagnosis of asthma and wheeze in the last year and subjects with neither feature and also provided the highest intra-class correlation coefficients.
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151 Citations1982Richard M. Nowak, Mark I. Pensler +5 more
PEFR correlated well with FEV1 at all stages of treatment and required admission or had problems after discharge of patients with both a pre-treatment and a post-treatment PEFR less than 300 L/min.
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141 Citations1988Benjamin Littenberg
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128 Citations1991Keith Wrenn, Corey M. Slovis +2 more
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121 Citations1993Bo Lundbäck, D W Rawlinson +1 more
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119 Citations1991Jos Kleijnen, Gerben ter Riet +1 more
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BMJComparison of effects of a self management booklet and audiocassette for patients with asthma.
100 Citations1988Douglas Jenkinson, June Davison +2 more
The paradoxical result whereby patients learnt more from the tape but preferred the book suggests that a distinction can be made between information that patients need and information that they want, which may be acquired better from a book.
ThoraxComparison of two high dose corticosteroid aerosol treatments, beclomethasone dipropionate (1500 micrograms/day) and budesonide (1600 micrograms/day), for chronic asthma.
85 Citations1986P Ebden, Alexandra L. Jenkins +2 more
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The LancetRegular vs as-needed inhaled salbutamol in asthma control
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The LancetComparison of oral-steroid sparing by high-dose and low-dose inhaled steroid in maintenance treatment of severe asthma
80 Citations1992Scott L. Hummel, Lasse Lehtonen
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ThoraxUse of inhaled corticosteroids in patients with mild asthma.
70 Citations1990S Lorentzson, J Bøe +2 more
Low doses of inhaled budesonide are effective in patients with mild symptomatic asthma, particularly for night time symptoms and early morning lung function, according to a double blind, parallel group study carried out.
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PubMedComparison of twice daily administration of a new corticosteroid budesonide with beclomethasone dipropionate four times daily in the treatment of chronic asthma.
57 Citations1982R F Willey, David Godden +4 more
British Journal of Diseases of the ChestA controlled trial of inhaled corticosteroids in patients receiving prednisone tablets for asthma
57 Citations1976
The theraprutic efficacy of inhaled beclomethasone dipropionate and inhaled betamethasone valerate in chronic asthma has been studied in 14 treatment centres in 158 patients who had previously been taking prednisone tablets regularly.
Archives of Internal MedicineA randomized trial to improve self-management practices of adults with asthma
56 Citations1990W. C. Bailey
PubMedAminophylline treatment in severe, acute asthma. A meta-analysis.
53 Citations1988Benjamin Littenberg
The American Journal of MedicineThe low risk of upper gastrointestinal bleeding in patients dispensed corticosteroids
50 Citations1991Jeffrey L. Carson, Brian L. Strom +3 more
Because the incidence of upper gastrointestinal bleeding in ambulatory patients treated with corticosteroids is so low, prophylactic therapy should be restricted to high-risk patients, if it is to be used at all.
PubMedHigh-dose inhaled budesonide in treatment of severe steroid-dependent asthma.
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Forty-five steroid-dependent asthmatic outpatients were treated twice daily for 51 weeks with a new inhalation steroid, budesonide (BUD), using a 750 ml spacer and Adrenal gland function improved considerably as prednisone intake decreased.
Archives of Internal MedicineAminophylline in the Treatment of Acute Asthma When ß2-Adrenergics and Steroids Are Provided
48 Citations1993Daniel Murphy
In the emergency department setting, aminophylline contributes no significant improvement in PEFR when beta 2-agonists and corticosteroids are being provided, while causing more side effects.
CHEST JournalComparative Safety and Efficacy of Single or Twice Daily Administration of Inhaled Beclomethasone in Moderate Asthma
47 Citations1994Michel Gagnon, Johanne Côté +3 more
In moderate asthma controlled with a twice-daily dose of inhaled beclomethasone, a single total daily dose administered in the late afternoon or in the evening provides as good control of asthma for 2 months.
European Respiratory JournalThe clinical efficacy of inhaled nedocromil sodium (Tilade) in the treatment of asthma
40 Citations1993AM Edwards, MT Stevens
The results demonstrate the efficacy of inhaled nedocromil sodium in a variety of patients with asthma, andOptimal effects are evident in patients with moderate asthma, currently receiving treatment with inhaled and oral bronchodilators.
Clinical & Experimental AllergySteroid sparing effect of nedocromil sodium in asthmatic patients on high doses of inhaled steroids
37 Citations1993Chung‐Wai Wong, Sue Cooper +2 more
In asthmatic patients controlled on high doses of inhaled steroids, nedocromil sodium was well tolerated but the smalt differences in steroid sparing effect between nedOCromil and placebo were not statistically significant.
AllergyHigh‐dose inhaled steroids in the management of asthma A comparison of the effects of budesonide and beclomethasone dipropionate on pulmonary function, symptoms, bronchial responsiveness and the adrenal function
36 Citations1992U. G. Svendsen, L. Frølund +4 more
A comparison of the effects of budesonide and beclomethasone dipropionate on pulmonary function, symptoms, bronchial responsiveness and the adrenal function is compared.
PubMedDose frequency in the treatment of asthmatics with inhaled topical steroid.
31 Citations1982Munch Ep, E. Taudorf +1 more
Current Medical Research and OpinionA placebo-controlled, blind comparison of nedocromil sodium and beclomethasone dipropionate in bronchial asthma
27 Citations1989Karl‐Christian Bergmann, C.-P. Bauer +1 more
Nedocromil sodium was comparable with and equivalent to inhaled beclomethasone dipropionate in nearly all of the parameters assessed, and both drugs were superior to placebo in the maintenance treatment of asthma in adult patients.
Journal of Allergy and Clinical ImmunologyA multicenter evaluation of the clinical benefits of cromolyn sodium aerosol by metered-dose inhaler in the treatment of asthma
26 Citations1988Malcolm N. Blumenthal, Jay E. Selcow +3 more
Cromolyn sodium by MDI is highly effective for controlling asthmatic symptoms, improving lung functions, and decreasing the need for concomitant bronchodilator medication use.
Journal of Allergy and Clinical ImmunologyLong-term, double-blind comparison of controlled-release albuterol versus sustained-release theophylline in adolescents and adults with asthma
25 Citations1990William E. Pierson, Craig LaForce +4 more
There was no evidence of tolerance to the bronchodilatory effect during 12 weeks in either treatment group and both treatment groups exhibited statistically significant increases in FEV1 from the pretreatment visit to all times of observation at weeks 1, 6, and 12.
PubMedOnce daily inhalation of budesonide in the treatment of chronic asthma: a clinical comparison.
25 Citations1985G Stiksa, C Glennow
In all but one patient, the reduced frequency of budesonide inhalations to only once daily has not given significantly different results compared with more frequent inhalations.
PubMedA comparison of inhaled albuterol and cromolyn in the prophylaxis of exercise-induced bronchospasm.
23 Citations1987Albert S. Rohr, Sheldon C. Siegel +4 more
PubMedA group comparative study of the safety and efficacy of nedocromil sodium (Tilade) in reversible airways disease: a preliminary report.
21 Citations1986van As A, Chick Tw +8 more
It can be concluded from this study that nedocromil sodium is a safe and effective drug in the management of asthma.
Current Medical Research and OpinionA comparative study of the efficacy of beclomethasone dipropionate delivered from a breath activated and conventional metered dose inhaler in asthmatic patients
20 Citations1993Kate Woodman, Peter Bremner +4 more
Treatment with beclomethasone dipropionate is clinically equivalent when delivered by the 'Autohaler' device or the conventional metered dose inhaler used efficiently in stable asthmatics.
CHEST JournalCharacteristics and Prognostic Value of Morning Dipping of Peak Expiratory Flow Rate in Stable Asthmatic Subjects
20 Citations1985Vincenzo Bellia, Fabio Cibella +3 more
European Respiratory JournalTherapeutic equivalence between bambuterol, 10 mg once daily, and terbutaline controlled release, 5 mg twice daily, in mild to moderate asthma
19 Citations1993AM Fugleholm, TB Ibsen +2 more
No difference in the bronchodilating effect was demonstrated between bambuterol, 10 mg once daily, and controlled release terbutaline, 5 mg twice daily and a tendency towards less tremor was seen with bambutol.
CHEST JournalA 1-Week Dose-Ranging Study of Inhaled Salmeterol in Patients With Asthma
17 Citations1994Edwin A. Bronsky, James P. Kemp +5 more
Salmeterol, 42 micrograms twice daily, is a safe and effective dosage for patients with mild-to-moderate asthma who are persistently symptomatic and require maintenance bronchodilator therapy.
European Respiratory JournalComparison between a new once-daily, bronchodilating drug, bambuterol, and terbutaline sustained-release, twice daily
17 Citations1988G Persson, Yvonne Gnosspelius +1 more
Whether bambuterol, given once daily, can control symptoms in asthmatic patients and to compare the bronchodilating effect and the side effects with those of terbutaline sustained-release (SR) tablets given twice daily are evaluated.
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15 Citations1995Thomas Bell
Prescribing peak flow meters and giving self management guidelines to all asthma patients is unlikely to improve mortality or morbidity, but patients whose asthma is severe may benefit from such an intervention.
Clinical & Experimental AllergyTwice or four times daily beclomethasone dipropionate in mild stable asthma?
14 Citations1985G. Boyd, Sara J. Abdallah +1 more
A double‐blind cross‐over study was conducted to establish if a twice daily regimen of beclomethasone dipropionate (BDP) was as effective in controlling asthma as a four times daily regimen.
Respiratory MedicineNedocromil sodium and sodium cromoglycate in patients aged over 50 years with asthma
12 Citations1993D.A.R. Boldy, Jon G. Ayres
The study suggests that there is no difference in response to nedocromil sodium or sodium cromoglycate in this older group of patients with asthma who are already on moderate doses of inhaled steroids.
PubMedBambuterol: a new long acting bronchodilating prodrug.
12 Citations1991Vilsvik Js, O Langaker +7 more
Bambuterol, a carbamate prodrug of terbutaline as a 5, 10, or 20-mg tablet was given once every evening to patients with asthma in a randomized double-blind crossover study.
PubMedTheophylline in maintenance treatment of chronic asthma: concentration-dependent additional effect to beta 2-agonist therapy.
8 Citations1987Bo Billing, R. Dahlqvist +4 more
There was a large interindividual variation in response to additional theophylline and only half of the subjects were responders, but those responding had increased therapeutic efficacy from a steady-state concentration in the range of 50-85 mumol/l compared to the lower concentration.
PubMedA multicentre double-blind group comparative trial of two dose levels of nedocromil sodium and placebo in the management of perennial extrinsic asthma.
6 Citations1986Dirceu Bartolomeu Greco, Negreiros Eb +3 more
The results suggest that nedocromil sodium is effective in the maintenance treatment of patients with perennial extrinsic asthma and further studies with longer-term treatment periods are suggested.
PubMedA double-blind comparative trial of nedocromil sodium and placebo in the management of bronchial asthma in patients routinely using oral bronchodilators.
6 Citations1986F. Cua-Lim, Benigno F. Agbayani +1 more
Nedocromil sodium, at the dosage used in this study, was well tolerated and provided a useful addition to asthma therapy.
Journal of Allergy and Clinical ImmunologyInhaled albuterol powder for the treatment of asthma—A dose-response study
6 Citations1985H.Alice Orgel, Eli O. Meltzer +2 more
PubMedA comparison of sustained-release terbutaline with ordinary salbutamol in bronchial asthma.
3 Citations1984R Beskow, C.H. Ericsson +3 more
The effects of a sustained-release preparation of terbutaline, depot tablets, 7.5 mg 2 times/day were compared with ordinary salbutamol tablets 4 mg 3 times/ day and the morning Peak-Flow was higher during the period on the depot tablets compared to that on the ordinary tablets.
PubMedA double-blind placebo-controlled trial of theophylline in general practice.
3 Citations1991Ron Neville, I K Crombie +1 more
British Journal of Diseases of the ChestComparison of twice daily administration of a new corticosteroid budesonide with beclomethasone dipropionate four times daily in the treatment of chronic asthma
1 Citations1982R WILLEY, D GODDEN +4 more
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