Adaptation of the glucocorticosterone response to novelty☆
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TL;DR
It was found that the 11-OHCS elevation due to a novel environment takes about 4 hr to return to resting levels and such elevations due to novelty are not constant over time but are subject to a ceiling effect.
Abstract
The 11-hydroxycorticosterone (11-OHCS) response in male rats to novelty as a stressor was examined. Since the emphasis to date has been on short durations of exposure to novel stimuli, up to 45 min only, the present study aimed at investigating the elevation and adaptation of the 11-OHCS response to prolonged exposure to novel environments. It was found that the 11-OHCS elevation due to a novel environment takes about 4 hr to return to resting levels. Net elevations of 11-OHCS induced by novelty in the rat appear to be affected by the underlying circadian rhythm. In addition such elevations due to novelty are not constant over time but are subject to a ceiling effect.