Projections from the nucleus accumbens to cholinergic neurons of the ventral pallidum: a correlated light and electron microscopic double-immunolabeling study in rat
Brain ResearchPublished 1 January 1992
La ́szlo ́ Za ́borsky, William E. Cullinan
Citations144
SJR quartileQ2
SJR score0.85
SNIP0.72
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
A correlated light- and electron microscopic double-immunolabeling study combining choline acetyltransferase immunocytochemistry with anterograde tracing of Phaseolus vulgaris leucoagglutinin (PHA-L) revealed that axons of the nucleus accumbens terminate on cholinergic neurons of the ventral pallidum.
Abstract
A correlated light- and electron microscopic double-immunolabeling study combining choline acetyltransferase immunocytochemistry with anterograde tracing of Phaseolus vulgaris leucoagglutinin (PHA-L) revealed that axons of the nucleus accumbens terminate on cholinergic neurons of the ventral pallidum. These findings are discussed with respect to the possibility that these cholinergic neurons may be part of parallel circuits, providing feedback to the same cortical and amygdaloid areas which innervate the nucleus accumbens.
Keywords
NeuroscienceBiochemistry, Genetics and Molecular Biology
Annual Review of NeuroscienceParallel Organization of Functionally Segregated Circuits Linking Basal Ganglia and Cortex
8,556 Citations1986Garrett E. Alexander, Mahlon R. DeLong +1 more
The basal ganglia serve primarily to integrate diverse inputs from the entire cerebral cortex and to "funnel" these influences, via the ventrolateral thalamus, to the motor cortex.
The Journal of Comparative NeurologyTopographical organization of the efferent projections of the medial prefrontal cortex in the rat: An anterograde tract‐tracing study with <i>Phaseolus vulgaris</i> leucoagglutinin
1,569 Citations1989Susan R. Sesack, Ariel Y. Deutch +2 more
The purpose of the present investigation was to examine the topographical organization of efferent projections from the cytoarchitectonic divisions of the mPFC (the medial precentral, dorsal anterior cingulate and prelimbic cortices) to determine whether the efferents from different regions within the prelimbics were organized topographically.
American Journal of Clinical PathologyFluorescent Antibody Methods
1,567 Citations1969Wadi A. Bardawil, Benjamin L. Toy
NeuroscienceThe organization of the projection from the cerebral cortex to the striatum in the rat
1,331 Citations1989Archibald J. McGeorge, Richard L. M. Faull
The detailed organization of the corticostriate projection has been investigated in the brain of the rat using the technique of retrograde transport of horseradish peroxidase following the placement of small, iontophoretic injections.
The Journal of Comparative NeurologyAmygdaloid projections to subcortical structures within the basal forebrain and brainstem in the rat and cat
1,290 Citations1978J. E. Krettek, Joseph L. Price
The efferent fiber connections of the nuclei of the amygdaloid complex with subcortical structures in the basal telencephalon, hypothalamus, midbrain, and pons have been studied in the rat and cat, using the autoradiographic method for tracing axonal connections.
NeuroscienceNew perspectives in basal forebrain organization of special relevance for neuropsychiatric disorders: The striatopallidal, amygdaloid, and corticopetal components of substantia innominata
1,221 Citations1988George F. Alheid, Lennart Heimer
Consideration of morphological and connectional characteristics of basal forebrain suggests that the corticopetal cell groups, together with magnocellular elements of the striatum, serve similar functional roles for the striatopallidal system, the extended amygdala, and the septal-diagonal band complex.
NeuroscienceSpecificity in the projection patterns of accumbal core and shell in the rat
1,203 Citations1991Lennart Heimer, Daniel S. Zahm +3 more
The efferent projections of the core and shell areas of the nucleus accumbens were studied with a combination of anterograde and retrograde tract-tracing methods, including Phaseolus vulgaris-leucoagglutinin, horseradish peroxidase and fluorescent tracers.
Brain ResearchAn anterograde neuroanatomical tracing method that shows the detailed morphology of neurons, their axons and terminals: Immunohistochemical localization of an axonally transported plant lectin,Phaseolus vulgaris leucoagglutinin (PHA-L)
1,203 Citations1984Charles R. Gerfen, Paule E. Sawchenko
A new neuroanatomical method for tracing connections in the central nervous system based on the anterograde axonal transport of the kidney bean lectin, Phaseolus vulgaris-leucoagglutinin (PHA-L) is described, which offers several advantages over present techniques.
Progress in NeurobiologyFunctional organization of the extrinsic and intrinsic circuitry of the parahippocampal region
914 Citations1989Menno P. Witter, Henk J. Groenewegen +2 more
NeuroscienceThe amygdalostriatal projection in the rat—an anatomical study by anterograde and retrograde tracing methods
887 Citations1982Ann E. Kelley, Valerie B. Domesick +1 more
Findings in additional autoradiographic material identify this relatively non-limbic striatal quadrant as the main region of distribution of the corticostriatal projection from the sensorimotor cortex.
NeuroscienceEfferent connections and nigral afferents of the nucleus accumbens septi in the rat
870 Citations1978Walle J. H. Nauta, G.P. Smith +2 more
The results of this study confirm earlier reports of accumbens projections to the globus pallidus and to dorsal strata of the medial half of the substantia nigra and confirm that this striatal region receives telen cephalic afferents from the hippocampus and amyg dala rather than from the neocortex.
NeuroscienceOrganization of the projections from the subiculum to the ventral striatum in the rat. A study using anterograde transport of Phaseolus vulgaris leucoagglutinin
869 Citations1987Henk J. Groenewegen, E. Vermeulen-Van der Zee +2 more
It appears that not only the entire nucleus accumbens, part of the so-called ventral striatum, receives fibres from the subiculum, but that the hippocampal projection area in the striatum includes also the most medial, ventral, rostral and caudal parts of the caudate-putamen complex.
The Journal of Comparative NeurologyAn autoradiographic examination of corticocortical and subcortical projections of the mediodorsal‐projection (prefrontal) cortex in the rat
795 Citations1979Robert M. Beckstead
A system of extensive corticocortical projections was revealed and it was indicated that different areas of the MD‐projection cortex have distinctive patterns in both their corticOCortical and subcortical projection.
NeuroscienceThe distribution of the projection from the hippocampal formation to the nucleus accumbens in the rat: An anterograde and retrograde-horseradish peroxidase study
751 Citations1982Ann E. Kelley, Valerie B. Domesick
The findings confirm earlier reports of such a projection from the hippocampal formation to the nucleus accumbens, and with the use of a relatively novel anterograde-horseradish peroxidase technique, provide a picture of fiber labelling representing the entire field of origin of the fornix system.
Advances in behavioral biologyThe Cholinergic Synapse and the Site of Memory
740 Citations1972J. A. Deutsch
NeuroscienceOrganization of the afferent connections of the mediodorsal thalamic nucleus in the rat, related to the mediodorsal-prefrontal topography
726 Citations1988Henk J. Groenewegen
The results of the present experiments indicate that the mediodorsal nucleus, on the basis of its cyto-, myelo- and chemoarchitecture as well as the organization of its reciprocal connections with the prefrontal cortex, can be subdivided into a medial, a central, a lateral and a paralamellar segment.
The Journal of Comparative NeurologyOrganization of cerebral cortical afferent systems in the rat. II. Magnocellular basal nucleus
707 Citations1984Clifford B. Saper
The distribution of retrogradely labeled basal forebrain neurons after cortical injections of wheat germ agglutinin‐horseradish peroxidase conjugate was essentially identical to that of neurons staining immunohistochemically for choline acetyltransferase.
Journal of Histochemistry & CytochemistryColor modification of diaminobenzidine (DAB) precipitation by metallic ions and its application for double immunohistochemistry.
660 Citations1982S M Hsu, E Soban
It is found that the CoCl2 + DAB is the ion of choice because it yields a distinct dark blue color that is easily distinguishable from brown DAB and the blue reaction product is very stable throughout the entire staining procedure.
The Journal of Comparative NeurologyThe origins of cholinergic and other subcortical afferents to the thalamus in the rat
595 Citations1987Ann E. Hallanger, Allan I. Levey +3 more
The origins of the cholinergic and other afferents of several thalamic nuclei were investigated in the rat by using the retrograde transport of wheat germ agglutinin conjugated‐horseradish peroxidase in combination with the immunohistochemical localization of choline acetyltransferase immunoreactivity.
The Journal of Comparative NeurologyOrganization of the thalamostriatal projections in the rat, with special emphasis on the ventral striatum
590 Citations1990Henk W. Berendse, Henk J. Groenewegen
NeuroscienceA note on the use of picric acid-paraformaldehyde-glutaraldehyde fixative for correlated light and electron microscopic immunocytochemistry
571 Citations1982Péter Somogyi, Hiroshi Takagi
The buffered picric acid paraformaldehyde fixative has been supplemented with glutaraldehyde and used as primary fixative for the perfusion of rat brains and it is suggested that the procedure may be useful for electron-microscopic sampling of immunoreactive structures occurring infrequently over a large area or for the electron- microscopically classified neurons.
The Journal of Comparative NeurologyThe topographic organization of associational fibers of the olfactory system in the rat, including centrifugal fibers to the olfactory bulb
553 Citations1983Marla B. Luskin, Joseph L. Price
This study analyzed the topographic organization of the associational fibers within the olfactory cortex of the rat, by using the autoradiographic method to label selectively the fibers arising in each area.
NeuroscienceBiochemical evidence for glutamate as neurotransmitter in corticostriatal and corticothalamic fibres in rat brain
544 Citations1981Frode Fonnum, Jon Storm‐Mathisen +1 more
The results show that the neostriatum receives glutamate-containing fibres from the neocortex, particularly the frontal part, which probably contains a high proportion of glutamate- and/or aspartate-containing nerve terminals but only a low proportion of these are derived from the contralateral cortex.
Brain ResearchApplication of coupled oxidation reaction to electron microscopic demonstration of horseradish peroxidase: cobalt-glucose oxidase method
542 Citations1979Kazuo Itoh, Akira Konishi +4 more
The coupled oxidation method, when applied to the histochemical demonstration of HRP in combination with cobalt method 1, was found to give excellent electron microscopical pictures of the electron dense reaction product.
Trends in NeurosciencesThe Mesolimbic Dopamine System: From Motivation to Action
517 Citations1992O.T. Phillipson
The author concludes that 'the NGFcholinergic, trophic-transmitter unit is central to contextual-spatial memory', and that the characteristics of contextual- Spatial memory are expressions of the structure and function of septohippocampal -NGF-cholin allergic hardware.
Progress in brain researchChapter 5 The anatomical relationship of the prefrontal cortex with the striatopallidal system, the thalamus and the amygdala: evidence for a parallel organization
505 Citations1991Henk J. Groenewegen, Henk W. Berendse +2 more
It is concluded that in this species, in analogy with the situation in primates, a number of parallel basal ganglia-thalamocortical circuits exist and the functions of the different subregions of the prefrontal cortex cannot be considered separately but must be viewed as components of the integrative functions ofThe circuits in which they are involved.
NeuroscienceCholecystokinin innervation of the ventral striatum: A morphological and radioimmunological study
488 Citations1985László Záborszky, George F. Alheid +4 more
The combined use of morphological and biochemical methods provided evidence for a partially overlapping distribution and possible interaction between an ascending brainstem and descending telencephalic cholecystokinin fiber systems within the striatum and related rostral forebrain areas.
ScienceThe Neostriatal Mosaic: Striatal Patch-Matrix Organization Is Related to Cortical Lamination
452 Citations1989Charles R. Gerfen
The results demonstrate that the compartmental organization of corticostriatal inputs is related to their laminar origin and secondarily to the cytoarchitectonic area of origin.
The EMBO JournalProduction of specific antisera and monoclonal antibodies to choline acetyltransferase: characterization and use for identification of cholinergic neurons.
442 Citations1982F. Eckenstein, H. Thoenen
The specificity of the immunohistochemical localization of ChAT has been established by comparing the labeling of pig retina using the antiserum with that obtained using the monoclonal antibody, which specifically identifies the same retinal structures.
The Journal of Comparative NeurologyEfferent connections of the ventral pallidum: Evidence of a dual striato pallidofugal pathway
435 Citations1985Suzanne N. Haber, Henk J. Groenewegen +2 more
Evidence is produced that the ventral pallidum can convey striatopallidal outflow of limbic antecedents not only into extrapyramidal circuits but also back into the circuitry of the limbic system.
NeuroscienceThe topographic order of inputs to nucleus accumbens in the rat
416 Citations1985O.T. Phillipson, A.C. Griffiths
It appeared that the heaviest volume of inputs projected to anteromedial accumbens, where output from hippocampus (CAI), subiculum, entorhinal and prefrontal cortices converged with output from amygdala, midline thalamus and ventral tegmentum.
Brain ResearchNeostriatal projections from individual cortical fields conform to histochemically distinct striatal compartments in the rat
407 Citations1986John P. Donoghue, Miles Herkenham
Using axonal transport and receptor localization techniques in the rat brain, it is found that striatal projections from architectonically distinct cortical fields conform to this compartmentalized plan, which may allow for prelimbic interactions with input from all other cortical areas.
Journal of NeuroscienceNeural projections from nucleus accumbens to globus pallidus, substantia innominata, and lateral preoptic-lateral hypothalamic area: an anatomical and electrophysiological investigation in the rat
407 Citations1983GJ Mogenson, LW Swanson +1 more
The anatomical organization and electrophysiological characteristics of a projection from the nucleus accumbens to anteroventral parts of the globus pallidus and to a subpallidal region that includes the substantia innominata, the lateral preoptic area, and anterior part of the lateral hypothalamic area were investigated in the rat.
American Journal of Tropical Medicine and HygieneFluorescent Antibody Methods
405 Citations1968Peter A. Ward
The Journal of Comparative NeurologyCortical projection patterns of the medial septum‐diagonal band complex
387 Citations1990Ronald P. Gaykema, Paul G.M. Luiten +2 more
Both distribution and morphology of the labeled basal forebrain efferents in the prefrontal, cingulate, and occipital cortices closely resemble the distribution and physiology of the cholinergic innervation as revealed by immunohistochemical demonstration of choline acetyltransferase.
Brain Research BulletinCholinergic systems in the rat brain: I. Projections to the limbic telencephalon
372 Citations1984Nancy J. Woolf, F. Eckenstein +1 more
No simple topographic pattern emerged to explain the cholinergic innervation of the limbic telencephalon, although an essentially reverse rostrocaudal organization was observed for afferents to the cingular region.
NeuroscienceExcitatory amino acid projections to the nucleus accumbens septi in the rat: A retrograde transport study utilizingd[3H]aspartate and [3H]GABA
342 Citations1987MacDonald J. Christie, Roger J. Summers +3 more
Afferents to the nucleus accumbens septi utilizing glutamate or aspartate have been investigated in the rat by autoradiography following injection and retrograde transport of D[3H]aspartate and [3H]:GABA failed to label perikarya in thalamus and amygdala, and a topographic distribution of label was absent in neocortex.
The Journal of Comparative NeurologySources of presumptive glutamergic/aspartergic afferents to the rat ventral striatopallidal region
338 Citations1987Terry A. Fuller, Fokje T. Russchen +1 more
The results indicate that 3H‐D‐Asp is a specific retrograde tracer and suggest that there are widespread, presumably excitatory, glutamergic and/or aspartergic inputs to the ventral striatum and pallidum.
NeuroscienceRamifications of the globus pallidus in the rat as indicated by patterns of immunohistochemistry
323 Citations1983Suzanne N. Haber, Walle J. H. Nauta
It is suggested that woolly fibers extending outward beyond the conventionally recognized borders of the pallidum represent pallidal elements innervated by enkephalin or substance P-positive fibers arising from ventromedial striatal regions in turn innervate by limbic structures.
Brain ResearchCortical projection patterns of magnocellular basal nucleus subdivisions as revealed by anterogradely transportedPhaseolus vulgaris leucoagglutinin
295 Citations1987P.G.M. Luiten, Ronald P. Gaykema +2 more
Comparison of young vs aged cases indicate that aging does not appear to have a profound influence on cortical innervation patterns, at least as studied with the PHA-L method.
The Journal of Comparative NeurologyTopographic organization of the ventral striatal efferent projections in the rhesus monkey: An anterograde tracing study
288 Citations1990Suzanne N. Haber, E. Lynd +2 more
Topographic organization of terminal fields in the globus pallidus and substantia nigra, the projections to non‐extrapyramidal areas, the relationship between projections from the nucleus accumbens and the other parts of the ventral striatum, and the comparison between ventral and dorsal striatal projections were studied.
NeuroscienceThe glutamate decarboxylase-, leucine enkephalin-, methionine enkephalin-and substance P-immunoreactive neurons in the neostriatum of the rat and cat: Evidence for partial population overlap
276 Citations1986G.R. Penny, Salman Afsharpour +1 more
These results provide evidence for chemical heterogeneity within the medium-sized neostriatal neurons, and provide the first evidence for coexistence of glutamate decarboxylase and substance P within a single neuron, and the first Evidence for the coexistence for substance P and [Met]enkephalin within single neurons of the central nervous system.
The Journal of Comparative NeurologyCholinergic projections from the basal forebrain to the basolateral amygdaloid complex: A combined retrograde fluorescent and immunohistochemical study
276 Citations1985Jørn Carlsen, László Záborszky +1 more
The location of cholinergic and non‐cholinergic neurons that project to the rat basolateral amygdaloid nucleus is examined by using choline acetyltransferase (ChAT) immunohistochemistry in combination with retrograde fluorescent tracing on the same tissue section.
Brain ResearchSubstance P-Containing terminals in synaptic contact with cholinergic neurons in the neostriatum and basal forebrain: a double immunocytochemical study in the rat
267 Citations1986J. Paul Bolam, C.A. Ingham +5 more
Antibodies against substance P and choline acetyltransferase (ChAT) have been used in a sequential double-immunocytochemical ultrastructural study of the rat forebrain and the cell bodies and proximal dendrites of identified cholinergic neurons in the neostriatum were found to receive symmetrical synaptic input from substance P-imuneactive boutons.
The Journal of Comparative NeurologyGABAergic input to cholinergic forebrain neurons: An ultrastructural study using retrograde tracing of HRP and double immunolabeling
250 Citations1986L. Z�borszky, Lennart Heimer +2 more
The results suggest that amygdalopetal, presumably cholinergic, neurons receive GAD‐positive terminals, and that direct GABAergic‐cholinergic and Cholinergic‐GABAergic interactions take place in the rostral forebrain.
Brain Research BulletinChanges in cortical acetylcholine output induced by modulation of the nucleus basalis
217 Citations1986Fiorella Casamenti, G Deffenu +2 more
The cholinergic neurons ascending to the cortex can be inhibited by GABA receptors located in the nucleus basalis and stimulated indirectly by dopaminergic fibres.
Progress in brain research“Perestroika” in the basal forebrain: Opening the border between neurology and psychiatry
203 Citations1991Lennart Heimer, José de Olmos +2 more
Considering the strategic position of the three basal forebrain systems discussed in the chapter, it is not difficult to envision how disruption of the functional integrity of any one of these systems can easily present itself with a multitude of symptoms that show little regard for traditional boundaries of neurologic and psychiatric disciplines.
Neuroscience LettersCholinergic projections from the basal forebrain to the frontal cortex: a combined fluorescent tracer and immunohistochemical analysis in the rat
200 Citations1983Nancy J. Woolf, F. Eckenstein +1 more
These projection neurons were large, demonstrated ChAT-like immunoreactivity, stained intensely for AChE following systemic administration of bis-(1-methylethyl)phosphorofluoridate, and were highly chromophilic.
Brain ResearchEvidence for the coexistence of glutamate decar☐ylase and Met-enkephalin immunoreactivities in axon terminals of rat ventral pallidum
195 Citations1985Daniel S. Zahm, László Záborszky +2 more
Conventional electron microscopy of immunostained ventral pallidum confirmed that the immunoreactive structures were boutons which made predominantly symmetrical synapses on ventral Pallidal cell bodies and dendrites.
The Journal of Comparative NeurologyBasal forebrain cholinergic and noncholinergic projections to the thalamus and brainstem in cats and monkeys
175 Citations1988André Parent, Denis Paré +2 more
The findings reveal the existence of cholinergic and noncholinergic basal forebrain projections to the thalamus and the brainstem in both cats and macaque monkeys and suggest that these projections may play a crucial role in the control of thalamic functions in mammals.
Plenum Press eBooksThe basal forebrain : anatomy to function
170 Citations1991T. Celeste Napier, Peter W. Kalivas +1 more
The Cholinergic Basal Forebrain has a critical role in Cortical Arousal and the relationship between Learning, Memory and Neuronal Responses in the Primate Basal forebrain is investigated.
Neuroscience LettersAmygdalostriatal projections in the rat. Topographical organization and fiber morphology shown using the lectin PHA-L as an anterograde tracer
167 Citations1984Fokje T. Russchen, Joseph L. Price
Amygdalostriatal projections in the rat were studied with the anterograde tracer phaseolus vulgaris leucoagglutinin (PHA-L), which allows direct visualization of axon morphology.
Advances in experimental medicine and biologyAfferents to Basal Forebrain Cholinergic Projection Neurons: An Update
159 Citations1991Lászlo Záborszky, William E. Cullinan +1 more
It is evident that BFC neurons in the rat are dispersed across a number of classically defined territories of the basal forebrain, rather than being arranged as distinct nuclear groups.
Brain ResearchThe distribution and origin of glutamate decar☐ylase and choline acetyltransferase in ventral pallidum and other basal forebrain regions
152 Citations1979Ivar Walaas, Frode Fonnum
Brain ResearchThe basolateral amygdaloid complex as a cortical-like structure
147 Citations1988Jørn Carlsen, Lennart Heimer
The results indicated that the basolateral amygdaloid nucleus corresponds in several features to a cortical structure, and is reciprocally related to other cortical regions as well as to the thalamus.
Journal of Histochemistry & CytochemistryDouble-label immunocytochemistry: combination of anterograde neuroanatomical tracing with Phaseolus vulgaris leucoagglutinin and enzyme immunocytochemistry of target neurons.
106 Citations1987Floris G. Wouterlood, John G. J. M. Bol +1 more
By the neuroanatomical tracing technique based on uptake, transport, and immunocytochemical detection of injected Phaseolus vulgaris leucoagglutinin (PHA-L), fiber trajectories of labeled neurons can be followed with great accuracy to their termination areas and the target neurons must be chemically characterized.
Brain ResearchLight microscopic evidence of striatal input to intrapallidal neurons of cholinergic cell group Ch4 in the rat: a study employing the anterograde tracerPhaseolus vulgaris leucoagglutinin (PHA-L)
104 Citations1986Elizabeth A. Grove, Valerie B. Domesick +1 more
PHA-L-filled striatofugal axons were seen to approach cholinergic neurons, identified with either acetylcholinesterase histochemistry or choline acetyltransferase immunohistochemistry, and, apparently, to contact the surface of such cells with axonal varicosities.
Brain ResearchBasal forebrain and mesopontine tegmental projections to the reticular thalamic nucleus: an axonal collateralization and immunohistochemical study in the rat
100 Citations1989Anne Jourdain, Kazue Semba +1 more
Results suggest that a subpopulation of cholinergic and non-cholinergic neurons in the basal forebrain and the mesopontine tegmentum may influence simultaneously the activity of neuron in the reticular thalamic nucleus and the cerebral cortex.
Brain ResearchA projection from the entorhinal cortex to the nucleus accumbens in the rat
90 Citations1981Philip F. Krayniak, Richard C. Meibach +1 more
The data reveal that the origin of the fimbrial projection to the nucleus accumbens in the rat arises predominantly from layers II--III of the anterior two-thirds of entorhinal cortex rather than from any part of hippocampal formation.
Plenum eBooksNeuroanatomical tract-tracing methods, 2 : recent progress
84 Citations1989Lennart Heimer, László Záborszky
While the previous volume (1981) was concerned with describing individual procedures, contributors here deal largely with tract-tracing protocols for the combination of two or more procedures in the same tissue sample.
Brain ResearchHypothalamic axons terminate on forebrain cholinergic neurons: an ultrastructural double-labeling study using PHA-L tracing and ChAT immunocytochemistry
79 Citations1989László Záborszky, William E. Cullinan
A correlated light and electron microscopic study combining choline acetyltransferase immunocytochemistry with anterograde tracing of Phaseolus vulgaris leucoagglutinin revealed that axons of lateral hypothalamic neurons terminate on forebrain cholinergic projection cells.
Experimental Brain ResearchThe distribution of the projection from the parataenial nucleus of the thalamus to the nucleus accumbens in the rat: An autoradiographic study
73 Citations1984Ann E. Kelley, L. Stinus
It is suggested that the parataenial nucleus is an important thalamic link between limbic and striatal processing and there is a nearly complete overlap between the parATAenial afferents and those coming from hippocampus.
Neuroscience LettersPharmacological manipulations of the substantia innominata-cortical cholinergic pathway
70 Citations1984Gary L. Wenk
Results suggest a regulatory role for enkephalinergic, GABAergic and glutamatergic afferents onto the basal forebrain cholinergic system within the SI.
Combinations of Tracer Techniques, Especially HRP and PHA-L, with Transmitter Identification for Correlated Light and Electron Microscopic Studies
64 Citations1989László Záborszky, Lennart Heimer
The tracing of neural circuits is greatly facilitated if a neuron’s projections and afferent synaptic connections as well as its transmitter content can be identified, and various attempts have been made in recent years to accomplish this goal.
NeuropharmacologyGabaergic regulation of the substantia innominata-cortical cholinergic pathway
63 Citations1982Paul L. Wood, Jocelyn M. Richard
Data with muscimol given parenterally, as well as local injections into the substantia innominata, further support an inhibitory function for this pathway in the regulation of the substantianata-cortical cholinergic projection.
Journal of Neural TransmissionDistribution of amygdala input to the nucleus accumbens septi: An electrophysiological investigation
46 Citations1991Clifton W. Callaway, Robert L. Hakan +1 more
The present results clarify the topographical distribution of amygdala input to the NAS, confirm that inputs from two limbic structures are integrated within theNAS, and further illustrate the electrophysiological heterogeneity of NAS neurons.
Journal of NeurocytologyDistribution of enkephalin-immunoreactive nerve fibres and terminals in the region of the nucleus basalis magnocellularis of the rat: a light and electron microscopic study
33 Citations1988R. Mart�nez-Murillo, I. Blasco +5 more
Results are consistent with the view that enkephalin-like substances in the rat might be synaptic transmitters or neuromodulators in the area of the NBM and that cholinergic neurons ofThe NBM (Ch4) are integrated into the circuitry of the basal ganglia.
Advances in behavioral biologySubstantia Innominata — Cortical Cholinergic Pathway: Regulatory Afferents
13 Citations1986Paul L. Wood, Paul McQuade
The large forebrain neurons of the substantia innominata extensively innervate the ipsilateral cerebral cortex and local injections of defined receptor agonists or antagonists into the SI have been compared with parenteral injections for their actions on cortical cholinergic function.