Sleep deprivation elevates plasma corticosterone levels in neonatal rats
Neuroscience LettersPublished 1 November 2001
Ilana S. Hairston, Norman F. Ruby, Sheila M. Brooke, Christelle Peyron, Daniel P. Denning, H. Craig Heller
Citations48
SJR quartileQ2
SJR score0.77
SNIP0.67
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
The observed response to sleep deprivation suggests that sleep loss is a significant stressor at this age, and younger animals are more sensitive to the effects of mild sleep deprivation than older ones.
Abstract
Plasma corticosterone (CORT) levels were measured after short periods of sleep deprivation in rats at postnatal days 12, 16, 20, and 24. There was an age-dependent increase in basal CORT levels and sleep deprivation significantly elevated CORT at all ages compared to non-sleep deprived controls. The levels of CORT after sleep deprivation in P16, P20 and P24 animals were similar, resulting in an age-dependent decrease of the magnitude of the response. Sleep deprived P12 animals had lower levels of CORT. However, the observed response to sleep deprivation suggests that sleep loss is a significant stressor at this age. These observations suggest that younger animals are more sensitive to the effects of mild sleep deprivation than older ones.
Keywords
Neuroscience
The LancetImpact of sleep debt on metabolic and endocrine function
3,657 Citations1999Karine Spiegel, Rachel Leproult +1 more
Sleep debt has a harmful impact on carbohydrate metabolism and endocrine function similar to those seen in normal ageing and, therefore, sleep debt may increase the severity of age-related chronic disorders.
Brain Research ReviewsMaturation of the adrenocortical stress response: Neuroendocrine control mechanisms and the stress hyporesponsive period
983 Citations1986Robert M. Sapolsky, Michael J. Meaney
This work has attempted to explain adrenocortical activity during this period in terms of the unique pattern of glucocorticoid-receptor concentrations that exist in the brain and pituitary of the neonatal rat, which ensures the low, stable corticoid levels that appear to be optimal for neuronal development in glucocortex-sensitive brain regions.
Developmental NeuroscienceEarly Environmental Regulation of Forebrain Glucocorticoid Receptor Gene Expression: Implications for Adrenocortical Responses to Stress; pp. 49–60
884 Citations2007Michael J. Meaney, Josie Diorio +7 more
The findings indicate that the early postnatal environment alters the differentiation of hippocampal neurons, and these data provide examples of early environmental programming of neural systems.
NatureTiming the end of nocturnal sleep
230 Citations1999Jan Born, Kirsten Hansen +3 more
The expectation that sleep will come to an end at a certain time induces a marked increase in the concentration of the hormone adrenocorticotropin in the blood one hour before waking, reflecting a preparatory process in anticipation of the end of sleep.
Developmental Brain ResearchEarly vs. late maternal deprivation differentially alters the endocrine and hypothalamic responses to stress
175 Citations1998Helga J. J. van Oers, E. R. de Kloet +1 more
The present study tested the hypothesis that the immediate effects of deprivation at pnd 3 vs. pnd 11 would provide an explanation for these paradoxical effects observed at day 20, and measured the basal and the stress-induced ACTH and corticosterone response at days 4 and 12, following 24 h of maternal deprivation.
SLEEPSleep Deprivation in the Rat: V. Energy Use and Mediation
166 Citations1989Bernard M. Bergmann, Carol A. Everson +6 more
Estimates of CO2 production by the doubly labelled water method of indirect calorimetry correlated with EE estimated from the caloric value of food, weight change, and wastes and confirmed an increase in EE during deprivation.
American Journal of Physiology-Regulatory, Integrative and Comparative PhysiologyDevelopment of REM and slow wave sleep in the rat
162 Citations1997Marcos G. Frank, H. Craig Heller
This work suggests that neonatal QS is not an immature form of SWS and that AS is best considered as an undifferentiated behavioral state from which bothSWS and REM sleep develop.
Journal of NeuroscienceHigh Corticosterone Levels in Prenatally Stressed Rats Predict Persistent Paradoxical Sleep Alterations
161 Citations1999Christine Dugovic, Stefania Maccari +3 more
Sleep–wake parameters in control and prenatally stressed adult rats and possible relationships with their corticosterone levels are studied to suggest that prenatal stress may be a useful animal model of depression.
NeuroscienceInfluence of stress duration on the sleep rebound induced by immobilization in the rat: a possible role for corticosterone
105 Citations1999Stéphane Marinesco, Chantal Bonnet +1 more
It is concluded that the reparative sleep rebound is suppressed after long and intense stress periods and that a prolonged glucocorticoid secretion could be one of the factors responsible for this effect.
American Journal of Physiology-Regulatory, Integrative and Comparative PhysiologyEffects of sleep deprivation in neonatal rats
85 Citations1998Marcos G. Frank, Roger N. Morrissette +1 more
The findings suggest not only that sleep is regulated in neonatal rats but that the accumulation and/or discharge of sleep need changes dramatically between the third and fourth postnatal weeks.
European Journal of Obstetrics & Gynecology and Reproductive BiologyThe importance of fetal/neonatal REM sleep
80 Citations1986Majid Mirmiran
Findings point to a role for REM during early development, so that more attention should be given to the potential hazards of medicines which induce reduced levels of REM and or disturbed monoamine activities in the brain during late prenatal and early postnatal life.
Neuroscience LettersThe effect of sleep deprivation and recovery sleep on plasma corticosterone in the rat
79 Citations1983Irene Tobler, Robert Murison +3 more
It is concluded that stress is not a major factor contributing to the massive effects of sleep deprivation on sleep parameters.
Physiology & BehaviorEffect of electric foot shocks, immobilization, and corticosterone administration on the sleep–wake pattern in the rat
70 Citations2000Gonzalo Vázquez-Palacios, Javier Velázquez‐Moctezuma
Data suggest that IMB applied to rats at the end of the dark cycle is effective in producing a sleep-elevating response, although this effect is enhanced during the dark phase.
American Journal of Physiology-Regulatory, Integrative and Comparative PhysiologyDevelopment of diurnal organization of EEG slow-wave activity and slow-wave sleep in the rat
62 Citations1997Marcos G. Frank, H. Craig Heller
The transient dissociation between diurnal organization in sleep-wake cycles and SWS DP suggests that circadian and homeostatic sleep regulatory mechanisms develop at different rates in the postnatal period.
Brain Research BulletinManipulations during forced wakefulness have differential impact on sleep architecture, EEG power spectrum, and Fos induction
41 Citations1998Fabio Garcı́a-Garcı́a, Luis Beltrán‐Parrazal +3 more
The results suggest that activation of cell clusters in the brain are related to the type of manipulation imposed on the rat during wakefulness and that variation in cell activation prior to sleep may be associated with sleep architecture and EEG power.
Behavioural PharmacologyInvolvement of stress in the sleep rebound mechanism induced by sleep deprivation in the rat: use of alpha-helical CRH(9???41)
36 Citations1998M M del C. Gonz lez, J-L Valatx
This peptide was used to evaluate the involvement of the stress component of the corticotropin-releasing hormone receptor antagonist in blocking the paradoxical sleep increase induced by stress.
Brain ResearchCorticosterone is a preferable ligand for measuring rat brain corticosteroid receptors: competition by RU 28362 and RU 26752 for dexamethasone binding in rat hippocampal cytosol
13 Citations1993Lauren Jacobson, Sheila M. Brooke +1 more
It is concluded that type I and II receptors in rat brain are best distinguished using [3H]corticosterone as the labelling ligand, with cold RU 28362 and dexamethasone to eliminate binding to type II and transcortin sites, respectively.