Fish-Oil Fatty Acid Supplementation in Active Rheumatoid Arthritis
Annals of Internal MedicinePublished 1 April 1987
Joel M. Kremer, William Jubiz, Ann Michalek, Richard I. Rynes, Lee E. Bartholomew, Jean Bigaouette
Citations548
SJR quartileQ1
SJR score3.38
SNIP3.27
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Abstract
fish-oil ingestion results in subjective alleviation of active rheumatoid arthritis and reduction in neutrophil leukotriene B4 production. Further studies are needed to elucidate mechanisms of action and optimal dose and duration of fish-oil supplementation.
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
The LancetEICOSAPENTAENOIC ACID AND PREVENTION OF THROMBOSIS AND ATHEROSCLEROSIS?
1,681 Citations1978J. Dyerberg
Unlike arachidonic acid, eicosapentaenoic acid (C20:5omega-3, E.P.A.) does not induce platelet aggregation in human platelet-rich plasma (P.R.X.A.P.), probably because of the formation of thromboxane A3 (T.G.I3) which does not have platelet aggregating properties.
New England Journal of MedicineEffect of Dietary Enrichment with Eicosapentaenoic and Docosahexaenoic Acids on in Vitro Neutrophil and Monocyte Leukotriene Generation and Neutrophil Function
1,339 Citations1985TH Lee, Richard L. Hoover +8 more
The effects of dietary fish-oil fatty acids on the function of the 5-lipoxygenase pathway of peripheral-blood polymorphonuclear leukocytes and monocytes were determined in seven normal subjects who supplemented their usual diet with daily doses of triglycerides.
Proceedings of the National Academy of SciencesTriene prostaglandins: Prostacyclin and thromboxane biosynthesis and unique biological properties
784 Citations1979Philip Needleman, Amiram Raz +3 more
It is possible that the triene prostaglandins are potential antithrombotic agents because their precursor fatty acids, as well as their transformation products, PGH, thromboxane A(3), and PGI, are capable of interfering with aggregation of platelets in platelet-rich plasma.
The LancetEFFECTS OF MANIPULATION OF DIETARY FATTY ACIDS ON CLINICAL MANIFESTATIONS OF RHEUMATOID ARTHRITIS
418 Citations1985J.A. Kremer, AnnV Michalek +7 more
On follow-up evaluation 1-2 months after stopping the diet, the experimental group had deteriorated significantly in patient and physician global evaluation of disease activity, pain assessment, and number of tender joints.
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397 Citations1983Reinhard Lorenz, Ulrich Spengler +3 more
Whatever the mechanism, this moderate supplement of w-3 polyunsaturated fatty acids markedly changed membrane phospholipids, which was associated with a shift toward less reactive platelets and a blunted circulatory response to pressure hormones.
Journal of Clinical InvestigationDietary enrichment with the polyunsaturated fatty acid eicosapentaenoic acid prevents proteinuria and prolongs survival in NZB x NZW F1 mice.
324 Citations1981James D. Prickett, Derrick R. Robinson +1 more
It is demonstrated that a diet high in EPA protects NZB x NZW F1 mice from the development of glomerulonephritis, and there was no evidence of essential fatty acid deficiency in any group.
Journal of Clinical InvestigationEffects of exogenous arachidonic, eicosapentaenoic, and docosahexaenoic acids on the generation of 5-lipoxygenase pathway products by ionophore-activated human neutrophils.
269 Citations1984T H Lee, Jean‐Michel Mencia‐Huerta +4 more
The metabolism of 5 and 10 micrograms/ml of exogenous EPA by ionophore-activated, [14C]arachidonic acid-labeled neutrophils not only generated 5-hydroxyeicosapentaenoic acid, 6-trans-L TB5, LTB5, and LTC5, but also stimulated the formation of 5-HydroxyeICosatetraenoic Acid, which is converted only to a monohydroxy
Advances in lipid researchFatty Acids and Immunity
229 Citations1978Christopher J. Meade, J. Mertin
Increased turnover of phospholipid fatty acids, following lymphocyte stimulation, requires a transferase to incorporate new fatty acids and a means of generating lysophosphatides and free fatty acids as substrates for this enzyme.
Arthritis & RheumatismDietary fish oil reduces progression of established renal disease in (NZB × NZW)F<sub>1</sub> mice and delays renal disease in BXSB and MRL/1 strains
124 Citations1986Dwight R. Robinson, James D. Prickett +3 more
It is demonstrated that delayed administration of a marine lipid diet, 25% menhaden oil (MO) by weight, until after the onset of overt renal disease, also resulted in significant improvement in rates of mortality, proteinuria, and histologic evidence of glomerular injury, compared with control animals fed a diet that contained mostly saturated fatty acids,25% beef tallow.
The Journal of ImmunologyDietary fish oil augments the induction of arthritis in rats immunized with type II collagen.
124 Citations1984James D. Prickett, David E. Trentham +1 more
The effects of a fish oil diet, enriched in highly unsaturated (delta-17) long chain fatty acids, on collagen arthritis are examined to demonstrate that inductive mechanisms in collagen arthritis can be altered by diet-induced changes in tissue fatty acid composition without essential fatty acid deficiency.
Journal of Clinical ImmunologyNutrition and immunity
111 Citations1981Robert A. Good
It is hopeful that the therapeutic possibilities of a scientifically modified diet may eventually be realized and added to clinical resources in combating immunodeficiencies, cancer, arteriosclerosis and other vascular diseases, renal disease, artherosclerosis, amyloidosis, vasculitis, and autoimmunities such as arthritis.
Journal of Biological ChemistryInfluence of fatty acyl substitution on the composition and function of macrophage membranes.
97 Citations1980Eileen M. Mahoney, William Scott +3 more
It is suggested that an increased content of saturated fatty acid in plasma membrane phospholipids leads to both reduced bilayer fluidity and reduced ability of the cell to interiorize plasma membrane.
PubMedNutritional modulation of immune responses.
61 Citations1980R A Good, Andrew Phillip West +1 more
In extensive experimental studies, the effects of dietary restriction in immunologic function and development of disease are analyzed and zinc deficiency produces progressive thymic involution and a progressive loss of T-cell immunity in mice and rats.
Prostaglandins Leukotrienes and MedicineDecreased leukotriene B4 synthesis by polymorphonuclear leukocytes from male patients with diabetes mellitus
43 Citations1984William Jubiz, Randall E. Draper +2 more
Because LTB4 is a potent chemoattractant and stimulates PMNL function, the defect in its synthesis may contribute to the predisposition to infections in the diabetic patient.