Can stem cells cross lineage boundaries?
Nature MedicinePublished 1 April 2001
David J. Anderson, Fred H. Gage, Irving L. Weissman
Citations487
SJR quartileQ1
SJR score18.33
SNIP8.71
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TL;DR
The authors critically examine the existing data, and suggest standards for the evaluation of these and future studies on stem cell "transdifferentiation".
Abstract
Stem cells have traditionally been characterized as either embryonic (pluripotent) or organ-specific. Recent work suggests that the latter can "transdifferentiate" into other cell types, carrying significant implications for possible clinical use of these cells. Here the authors critically examine the existing data, and suggest standards for the evaluation of these and future studies.
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
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