Arrangements in the modular evolution of proteins
Trends in Biochemical SciencesPublished 25 July 2008
Andrew D. Moore, Åsa K. Björklund, Diana Ekman, Erich Bornberg‐Bauer, Arne Elofsson
Citations221
SJR quartileQ1
SJR score4.16
SNIP2.34
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TL;DR
The analysis of protein-domain rearrangements has provided us with functional and evolutionary insights and has aided improved functional predictions and domain assignments to previously uncharacterised genes and proteins.
Abstract
It has been known for the last couple of decades that proteins evolve partly through rearrangements of larger fragments, typically domains. These units are considered the basic modules of protein structure, evolution and function. In the last few years, the analysis of protein-domain rearrangements has provided us with functional and evolutionary insights and has aided improved functional predictions and domain assignments to previously uncharacterised genes and proteins. Although some mechanisms that govern modular rearrangements of protein domains have been uncovered, such as the addition or deletion of a single N- or C-terminal domain, much is still unknown about the genetics behind these arrangements.
Keywords
Biochemistry, Genetics and Molecular Biology
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