Hippocampal 5-HT synthesis and release in vivo is decreased by infusion of 8-OHDPAT into the nucleus raphe dorsalis
Neuroscience LettersPublished 1 May 1989
Peter H. Hutson, G. S. Sarna, Mark T. O’Connell, G. Curzon
Citations199
SJR quartileQ2
SJR score0.77
SNIP0.67
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
Infusion of the serotonin-1A (5-HT1A) agonist, 8-hydroxy-2-di(n-propylamino)tetralin (8-OHDPAT) into the dorsal raphe, decreased extracellular 5-HT as measured by dialysis in the ventral hippocampus and also decreased 5- HT synthesis in both the hippocampus and the rest of the brain.
Abstract
Infusion of the serotonin-1A (5-HT1A) agonist, 8-hydroxy-2-di(n-propylamino)tetralin (8-OHDPAT) (0.5, 1.0 and 2.0 micrograms) into the dorsal raphe, decreased extracellular 5-HT as measured by dialysis in the ventral hippocampus and also decreased 5-HT synthesis in both the hippocampus and the rest of the brain as measured by 5-hydroxytryptophan (5-HTP) accumulation following decarboxylase inhibition by NSD 1015.
Keywords
MedicineNeuroscience
SynapseElectrophysiological responses of serotoninergic dorsal raphe neurons to 5‐HT<sub>1A</sub> and 5‐HT<sub>1B</sub> agonists
845 Citations1987Jeffrey Sprouse, George K. Aghajanian
D dorsal raphe 5‐HT neurons appear highly responsive to 5‐ht1A, but not to 5-HT1B compounds; these findings are discussed with regard to the 5‐ HT receptor subtypes as candidates for the somatodendritic autoreceptor of dorsal raphes neurons.
Journal of Neural Transmission8-hydroxy-2-(di-n-propylamino)tetralin, 8-OH-DPAT, a potent and selective simplified ergot congener with central 5-HT-receptor stimulating activity
515 Citations1982Stephan Hjorth, Arvid Carlsson +6 more
It was demonstrated that the simplified ergot congener 8-hydroxy-2-(di-n-propylamino)tetralin, 8-OH-DPAT, is able to elicit pronounced biochemical and behavioural alterations indicative of central serotoninomimetic activity, and may be regarded the most potent, selective centrally acting 5-HT agonist described to date.
Life SciencesScope and limitations of in vivo brain dialysis: A comparison of its application to various neurotransmitter systems
429 Citations1987Ben H.C. Westerink, G. Damsma +3 more
It is concluded that dopamine, noradrenaline and acetylcholine found in the dialysate are directly derived from neurotransmission, whereas the overflow of excitatory amino acid neurotransmitters is related to neurogenic as well as to metabolic events.
European Journal of PharmacologyPresynaptic 5-HT autoreceptors on serotonergic cell bodies and/or dendrites but not terminals are of the 5-HT1A subtype
391 Citations1985Daniel Vergé, G. Daval +4 more
Journal of Clinical PsychopharmacologySerotonergic Neuronal Systems
344 Citations1987Mark E. Molliver
It is proposed that there are two anatomically and functionally distinct serotonergic projections to cortex and that neurons in the dorsal raphe nucleus appear to play a major role in the control of affective state.
European Journal of PharmacologyNeurochemical and behavioural evidence for mediation of the hyperphagic action of 8-OH-DPAT by 5-HT cell body autoreceptors
208 Citations1986Peter H. Hutson, Colin T. Dourish +1 more
Results suggest that 8-OH-DPAT induced hyperphagia is mediated via a agonist action on somatodendritic 5-HT autoreceptors, and decreased 5-HIAA and 5- HIAA/5-HT ratio in several brain regions.
Neurochemistry InternationalEvidence for the localization of 5HT1A binding sites on serotonin containing neurons in the raphe dorsalis and raphe centralis nuclei of the rat brain
200 Citations1985Dinah Weissmann‐Nanopoulos, Evelyne Mach +3 more
It is postulated that these 5HT1A sites correspond in these raphe nuclei to 5HT autoreceptors, closely correlated to the already known distribution of 5HT containing elements.
Journal of NeurochemistryMonitoring the Effect of a Tryptophan Load on Brain Indole Metabolism in Freely Moving Rats by Simultaneous Cerebrospinal Fluid Sampling and Brain Dialysis
124 Citations1985Peter H. Hutson, G. S. Sarna +2 more
Results in general show the value of repeated CSF sampling and intracerebral dialysis for concurrent monitoring of changes of indole metabolism in the whole brain and a specific brain region, respectively.