Particulate air pollution and the blood
ThoraxPublished 1 November 1999Open access
Anthony Seaton, Anne K. Soutar, V. L. S. Crawford, R A Elton, Susan McNerlan, John W. Cherrie
Citations406
SJR quartileQ1
SJR score2.45
SNIP2.08
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TL;DR
The changes in haemoglobin adjusted for albumin suggest that inhalation of some component of PM10 may cause sequestration of red cells in the circulation, and it is proposed that an action of such particles either on lung endothelial cells or on erythrocytes themselves may be responsible for changing red cell adhesiveness.
Abstract
This investigation is the first to estimate personal exposures to PM(10) and to demonstrate associations between haematological indices and air pollution. The changes in haemoglobin adjusted for albumin suggest that inhalation of some component of PM(10) may cause sequestration of red cells in the circulation. We propose that an action of such particles either on lung endothelial cells or on erythrocytes themselves may be responsible for changing red cell adhesiveness. Peripheral sequestration of red cells offers an explanation for the observed cardiovascular effects of particulate air pollution.
Keywords
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