Limbic Responsiveness to Procaine in Cocaine-Addicted Subjects
American Journal of PsychiatryPublished 1 March 2001
Bryon Adinoff, Michael D. Devous, Susan M. Best, Mark S. George, Deanna Alexander, Kelly Payne
Citations61
SJR quartileQ1
SJR score5.27
SNIP3.68
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
The pattern of hypoperfusion in the placebo state followed by heightened activation with procaine in the cocaine-addicted subjects is similar to the pattern of interictal hypoperFusion and ictal hyperperfusion that has been observed in subjects with epilepsy.
Abstract
The pattern of hypoperfusion in the placebo state followed by heightened activation with procaine in the cocaine-addicted subjects is similar to the pattern of interictal hypoperfusion and ictal hyperperfusion that has been observed in subjects with epilepsy. The findings for the cocaine-addicted subjects may thus represent evidence of localized (orbitofrontal) sensitization.
Keywords
MedicineNeuroscienceBiochemistry, Genetics and Molecular Biology
Cerebral CortexEmotion, Decision Making and the Orbitofrontal Cortex
3,533 Citations2000Antoine Bechara
The somatic marker hypothesis provides a systems-level neuroanatomical and cognitive framework for decisionMaking and the influence on it by emotion and the relationship between emotion, decision making and other cognitive functions of the frontal lobe, namely working memory is reviewed.
The British Journal of PsychiatryThe SCL-90 and the MMPI: A Step in the Validation of a New Self-Report Scale
2,307 Citations1976Leonard R. Derogatis, Karl Rickels +1 more
Comparisons of the nine primary symptom dimensions of the SCL-90 with the set of MMPI scales reflected very high convergent validity for the Scl-90, with secondary patterns of correlations showing high interpretative consistency.
Journal of Cerebral Blood Flow & MetabolismA Three-Dimensional Statistical Analysis for CBF Activation Studies in Human Brain
2,055 Citations1992Keith J. Worsley, Alan C. Evans +2 more
A simple method for determining an approximate p value for the global maximum based on the theory of Gaussian random fields is described, which focuses on the Euler characteristic of the set of voxels with a value larger than a given threshold.
Cerebral CortexAddiction, a Disease of Compulsion and Drive: Involvement of the Orbitofrontal Cortex
1,248 Citations2000Nora D. Volkow
Society for Industrial and Applied Mathematics eBooksThe Geometry of Random Fields
966 Citations2010Robert J. Adler
Proceedings of the National Academy of SciencesActivation of memory circuits during cue-elicited cocaine craving.
947 Citations1996Stephanie Grant, Edythe D. London +7 more
Correlations of metabolic increases in the dorsolateral prefrontal cortex, medial temporal lobe, and cerebellum with self-reports of craving suggest that a distributed neural network, which integrates emotional and cognitive aspects of memory, links environmental cues with cocaine craving.
American Journal of PsychiatryNeuroanatomical correlates of externally and internally generated human emotion
718 Citations1997Eric M. Reiman, Richard D. Lane +6 more
This study identified brain regions that participate in externally and internally generated human emotion, suggesting that these regions participate in aspects of emotion that do not depend on the nature of the emotional stimulus.
Alcoholism Clinical and Experimental ResearchThe Obsessive Compulsive Drinking Scale: A Self‐Rated Instrument for the Quantification of Thoughts about Alcohol and Drinking Behavior
678 Citations1995Raymond F. Anton, Darlene H. Moak +1 more
Initial results indicate that the OCDS seems to validly measure a dimension of alcohol dependence, because it decreased from baseline during alcohol reduction and increased in relationship to relapse drinking.
American Journal of PsychiatryFunctional Magnetic Resonance Imaging of Human Brain Activation During Cue-Induced Cocaine Craving
441 Citations1998Luis C. Maas, Scott E. Lukas +6 more
Functional MRI results suggest that functional MRI may be a useful tool to study the neurobiological basis of cue-induced craving.
SynapseLong‐Term frontal brain metabolic changes in cocaine abusers
414 Citations1992Nora D. Volkow, Robert Hitzemann +5 more
It is proposed that chronic cocaine use can also cause clinically silent brain dysfunction, and this work aims to clarify the role of cocaine use in this condition.
Biological PsychiatryThe functional neuroanatomy of anxiety: a study of three disorders using positron emission tomography and symptom provocation
391 Citations1997Scott L. Rauch, Cary R. Savage +3 more
Cerebral CortexOrbitofrontal Cortex and Human Drug Abuse: Functional Imaging
360 Citations2000Edythe D. London
Evidence has been obtained that activity in the orbitofrontal cortex and its connections plays a role in several components of the maladaptive behavior of substance abuse, including expectancy, craving and impaired decision making.
Life SciencesRegional brain metabolic activation during craving elicited by recall of previous drug experiences
338 Citations1999Gene‐Jack Wang, Nora D. Volkow +6 more
Activation of the temporal insula, a brain region involved with autonomic control, and of the orbitofrontal cortex, abrain region involvedWith expectancy and reinforcing salience of stimuli, during the cocaine theme support their involvement with craving in cocaine addicted subjects.
Journal of NeuropsychiatryCerebral perfusion and neuropsychological consequences of chronic cocaine use
266 Citations1993Tony L. Strickland, Ismaël Mena +6 more
It is indicated that long-term cocaine use may produce sustained brain perfusion deficits and persistent neuropsychological compromise in some subgroups of cocaine-abusing patients.
Annals of NeurologyAnatomical correlates of electrical and behavioral events related to amygdaloid kindling
248 Citations1978Jerome Engel, Leslie Wolfson +1 more
It is suggested that three discrete anatomical systems underlie the generation of partial seizures, generalized motor seizures, and local afterdischarge in rats.
Archives of General PsychiatryAnterior Paralimbic Mediation of Procaine-Induced Emotional and Psychosensory Experiences
203 Citations1996Terence A. Ketter
Patients with intense procaine-induced fear compared with those with euphoria had greater increases in left amygdalar CBF, and different clinical responses appeared to be associated with different patterns of CBF changes.
PsychophysiologyFunctional neuroanatomy of visually elicited simple phobic fear: Additional data and theoretical analysis
196 Citations1995M Fredrikson, Gustav Wik +3 more
Journal of Neurology Neurosurgery & PsychiatryIctal/postictal SPECT in the pre-surgical localisation of complex partial seizures.
181 Citations1993Roderick Duncan, James C. Patterson +3 more
It is concluded that ictal/postictal SPECT is a reliable technique for the presurgical localisation of complex partial seizures in patients with medically intractable complexpartial seizures during or soon after a seizure.
American Journal of PsychiatryFunctional neuroanatomy of CCK4-induced anxiety in normal healthy volunteers
171 Citations1995Chawki Benkelfat, Jacques Bradwejn +5 more
Some of the temporopolar cortex CBF activation peaks previously reported in humans in association with drug- and non-drug-induced anxiety, as well as the increase in regional CBF in the claustrum-insular-amygdala region, may be of vascular and/or muscular origin.
NeuropsychopharmacologySelective Sensitization to the Psychosis-Inducing Effects of Cocaine: A Possible Marker for Addiction Relapse Vulnerability?
162 Citations1997Elsa J. Bartlett
A preliminary followup of patients who were sensitized or nonsensitized to psychosis development suggests that rehospitalization for treatment of addiction may be more frequent in the sensitized group.
Cerebral CortexOrbital and Medial Prefrontal Cortex and Psychostimulant Abuse: Studies in Animal Models
157 Citations2000Linda J. Porrino
Data from metabolic mapping studies are described that indicate that the pattern of functional activity within medial and orbitofrontal cortex shifts as the duration of exposure to drugs such as cocaine is extended, which may reflect progressive phases of the addictive process.
Psychiatry ResearchA controlled positron emission tomography study of obsessive and neutral auditory stimulation in obsessive-compulsive disorder with checking rituals
154 Citations1996Jean Cottraux, Daniel Gérard +10 more
This study suggests specific abnormalities of information processing in the basal ganglia and temporal structures of compulsive checkers in nondepressed patients with obsessive-compulsive disorder.
American Journal of PsychiatryCocaine-induced paranoia and psychosis proneness
136 Citations1991Sally L. Satel, William S. Edell
Heavy cocaineusers who experience transient paranoia while intoxicated may be at higher risk for development of psychosis than cocaine users who do not experience paranoia.
American Journal of PsychiatryCocaine precipitation of panic disorder
114 Citations1986T A Aronson, Timothy Craig
Three patients are described whose panic disorder began during recreational use of cocaine and continued autonomously even after the drug was stopped, and theoretical and practical implications are discussed.
PubMedGender differences in cerebral perfusion in cocaine abuse: technetium-99m-HMPAO SPECT study of drug-abusing women.
106 Citations1994Jonathan M. Levin, B.L. Holman +5 more
It is suggested that cocaine-dependent women have fewer abnormalities in cerebral perfusion than cocaine- dependent men, but that concurrent abuse of heroin and cocaine is associated with more perfusion abnormalities in both sexes.
Journal of NeuropsychiatryBasal ganglia/limbic striatal and thalamocortical involvement in craving and loss of control in alcoholism
78 Citations1990Jack G. Modell, James M. Mountz +1 more
The authors explore the possible role of basal ganglia/limbic striatal and thalamocortical circuits in craving and loss of control in alcohol abuse and dependence.
American Journal of PsychiatryTreatment of cocaine-induced panic disorder
76 Citations1989Alan K. Louie, R A Lannon +1 more
Ten patients who developed panic attacks only after substantial cocaine use were described, and the timing of the onset of symptoms and the fact that only one patient had a first-degree relative with panic disorder were more suggestive of acquired than primary panic disorder.
Anesthesia & AnalgesiaLocal Anesthetic-Induced Convulsions in Man
67 Citations1966JOSE E. USUBIAGA, JAIME WIKINSKI +3 more
Journal of NeuropsychiatrySelective Pharmacological Activation of Limbic Structures in Human Volunteers
60 Citations1998David Servan-Schreiber, William M. Perlstein +2 more
This study confirms that selective anterior limbic/paralimbic activity in normal human volunteers evokes many emotional phenomena as well as common "ill-defined" symptoms observed in clinical conditions.
Anesthesia & AnalgesiaLocal Anesthetic-Induced Convulsions in Man
59 Citations1966José E. Usubiaga, Jaime A. Wikinski +3 more
PubMedLocalization of neurochemical effects of cocaine and other stimulants in the human brain.
52 Citations1988L.R. Baxter, Joel Schwartz +8 more
Positron emission tomography offers a unique opportunity for studying the cerebral biochemistry of cocaine abuse in humans and the effects of cocaine and related psychostimulants on the brain's energy requirements and on catecholamine neurotransmitter systems.
Experimental NeurologyAugmentation of the behavioral and electrophysiologic response to cocaine by chronic administration in the rat☆
37 Citations1977Jeffrey S. Stripling, Everett H. Ellinwood
A subsequent test injection of cocaine indicated that the augmentation of the electrophysiologic response to cocaine persisted for an average of 20 days or more, and persistence of the augmented behavioral effect was also found.
PubMedLongterm neurological complications of chronic, habitual cocaine abuse.
34 Citations1991A. Pascual–Leone, Anil Dhuna +1 more
It is argued that prolonged and frequent cocaine abuse leads to biochemical and vascular cerebral insults that eventually may cause functional and structural abnormalities affecting predominantly the fronto-temporal areas.
Journal of NeuroimagingSPECT Functional Brain Imaging; Technical Considerations
29 Citations1995Michael D. Devous
SPECT will only achieve its full potential in the management of patients with cerebral pathology through close cooperation among members of the nuclear medicine, neurology, psychiatry, neurosurgery, and internal medicine specialties.
Brain TopographyProcaine-lnduced increases in limbic rCBF correlate positively with increases in occipital and temporal EEG fast activity
28 Citations1995Priti I. Parekh, John Spencer +6 more
The most striking finding was that the increases in occipital and temporal omega activity from baseline to procaine positively correlated with rCBF increases in the amygdala and its efferents, which suggests that omega activity may reflect activation of deeper brain limbic structures.
Progress in Neuro-Psychopharmacology and Biological PsychiatryBasic science and clinical aspects of procaine HCl as a limbic system excitant
28 Citations1985Robert E. Adamec, Cannie Stark-Adamec +2 more
The results tentatively support the hypothesis that some psychiatric patients have hyperexcitable limbic systems, and those that do, show a positive behavioural response to carbamazepine.
PharmacopsychiatryNeurobiological and Anthropological Aspects of Compulsions and Rituals
27 Citations1999Andreas Heinz
It is suggested that simple motor tics are caused by a stimulus-dependent disinhibition of stereotypies encoded in the head of the caudate, while more complex compulsions are associated with a serotonergic disin inhibition of frontocortical-striatal circuits in GTS and obsessive-compulsive disorder.
Progress in Neuro-Psychopharmacology and Biological PsychiatryA SPECT HMPAO study of regional cerebral blood flow in depressed adolescents and normal controls
24 Citations1999Robert A. Kowatch, Michael D. Devous +5 more
Adolescents with MDD show rCBF abnormalities similar to those found in adult MDD r CBF studies, and further controlled studies with larger numbers of MDD subjects and normal age- and gender-matched controls are necessary before any definitive conclusions can be made.
Brain ResearchA pharmacogenetic evaluation of the role of local anesthetic actions in the cocaine kindling process
23 Citations1991Robert J. Marley, Jeffrey M. Witkin +1 more
Depending on the genetic background of the subject, the repeated administration of lidocaine, or cocaine, resulted in the development of sensitization or tolerance to the convulsant effects of lidOCaine in an identical manner.
Annals of Clinical PsychiatryA Possible Neurophysiological Basis of Cocaine Craving
22 Citations1990James A. Halikas, Kenneth Kuhn
It is suggested that cocaine craving may be the behavioral manifestation of kindling, the neuronal supersensitivity induced by cocaine in animal studies, and that caution should be observed in applying this preliminary observation to general clinical use.
Naunyn-Schmiedeberg s Archives of PharmacologyÜber die Wirkung längerer Cocaindarreichung bei Tieren
17 Citations1912Julius Grode