PHYSIOLOGY OF THE INHIBITION BY GLUCOSE OF THE INDUCED SYNTHESIS OF THE β-GALACTOSIDE-ENZYME SYSTEM OF <i>ESCHERICHIA COLI</i>
Journal of BacteriologyPublished 1 November 1959Open access
Melvin Cohn, Kengo Horibata
Citations119
SJR quartileQ2
SJR score1.09
SNIP0.85
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TL;DR
The experiments described here are best understood in terms of the hypothesis that induced enzymes are those whose synthesis can be repressed by some derivative of the carbon source and the inducer relieves the repression.
Keywords
Agricultural and Biological SciencesBiochemistry, Genetics and Molecular BiologyChemical Engineering
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216 Citations1959Leonard A. Herzenberg
The constant differential rate in the cryptic and in the permease-blocked normal strain was discussed as evidence that the enzyme forming system for β-galactosidase does not increase in amount in response to inducer, indicating that a sterically specific site, distinct from galactosIDase or permease, is involved in induction.
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Journal of BacteriologyINHIBITION BY GLUCOSE OF THE INDUCED SYNTHESIS OF THE β-GALACTOSIDE-ENZYME SYSTEM OF <i>ESCHERICHIA COLI</i> . ANALYSIS OF MAINTENANCE
150 Citations1959Melvin Cohn, Kengo Horibata
The Novick-Weiner effect and the one to be analyzed here prove to be aspects of the same situation and a heterogeneity with respect to the induced synthesis of ,B-galactosidase simulating genetic differences could be provoked within a growing population of otherwise identical cells.
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115 Citations1959Melvin Cohn, Kengo Horibata
The kinetics of induction of the galactozymase of certain yeasts and the permease-3-galactosidase system of Escherichia coli can, under certain conditions, be described as autocatalytic.
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Amino acid, purine-pyrimidine, and vitamin B12 supplementation did not affect the complete suppression exerted by glucose on the induced biosynthesis of myo-inositol dehydrogenase, glycerol dehydrogensase, and histidase in a strain of Aerobacter aerogenes.
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The work reported in this paper was undertaken to study these inhibitions and to diseover the relationship, if any, between them and the "glucose effect."
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6 Citations1953S. D. Wainwright