Allelic variants interaction of dopamine receptor D4 polymorphism correlate with personality traits in young Korean female population
American Journal of Medical Genetics Part B Neuropsychiatric GeneticsPublished 27 November 2002
Heon‐Jeong Lee, Heon‐Jeong Lee, Hong Seock Lee, Hong Seock Lee, Yong‐Ku Kim, Seung Hyun Kim
Citations40
SJR quartileQ2
SJR score0.66
SNIP0.63
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TL;DR
It was found that the interaction between the two alleles of DRD4 polymorphism, 48‐bp VNTR and −521 C/T, were significantly high on NS and persistence personality scores, suggesting that the variants ofDRD4 gene influence the NS and P (persistent) personality traits.
Abstract
Polymorphism in exon III of the dopamine D4 receptor (DRD4) gene has been implicated to be associated with the human personality trait of novelty seeking (NS). For this study, we have investigated the possible association between 48-bp VNTR in exon III and -521 C/T SNP of the DRD4 and personality traits among young ( approximately 14 years of age) Korean female population. We found that the interaction between the two alleles of DRD4 polymorphism, 48-bp VNTR and -521 C/T, were significantly high on NS (F = 4.88, P = 0.029) and persistence (P) (F = 5.05, P = 0.027) personality scores, suggesting that the variants of DRD4 gene influence the NS and P (persistent) personality traits. When analyzed independently, however, the two different alleles of DRD4 polymorphisms, 48-bp VNTR and -521 C/T, there was no direct correlation with the personality traits.
Keywords
PsychologyNeuroscienceBiochemistry, Genetics and Molecular Biology
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