The functional role of the β‐subunit in the maturation and intracellular transport of Na,K‐ATPase
FEBS LettersPublished 1 July 1991
Käthi Geering
Citations222
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SJR score1.22
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TL;DR
This brief review summarizes the experimental data supporting the hypothesis that assembly of the β‐sub unit is needed for the α‐subunit to acquire the correct, stable configuration necessary for the acquisition of functional properties and its exit from the ER.
Abstract
The minimal functional enzyme unit of Na,K-ATPase consists of an alpha-beta complex. The alpha-subunit bears all functional domains of the enzyme and so far a regulatory role for the beta-subunit in the catalytic cycle has not been established. On the other hand, increasing experimental evidence suggests that the beta-subunit is an indispensable element for the structural and functional maturation of the enzyme as well as its intracellular transport to the plasma membrane. This brief review summarizes the experimental data supporting the hypothesis that assembly of the beta-subunit is needed for the alpha-subunit to acquire the correct, stable configuration necessary for the acquisition of functional properties and its exit from the ER.
Keywords
MedicineBiochemistry, Genetics and Molecular BiologyEngineering
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