Cerebral white matter lesions and subjective cognitive dysfunction
NeurologyPublished 12 June 2001Open access
Jan Cees de Groot, F.E. de Leeuw, Matthijs Oudkerk, Albert Hofman, J. Jolles, Monique M.B. Breteler
Citations310
SJR quartileQ1
SJR score2.40
SNIP1.82
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
Cerebral white matter lesions are associated with subjective cognitive failures and in particular with reporting progression of these failures, even in the absence of objective cognitive impairment.
Abstract
WML are associated with subjective cognitive failures and in particular with reporting progression of these failures, even in the absence of objective cognitive impairment.
Keywords
MedicineNeuroscience
British Journal of Clinical PsychologyThe Cognitive Failures Questionnaire (CFQ) and its correlates
2,929 Citations1982D. Ε. Broadbent, P. F. Cooper +2 more
A questionnaire measure of self-reported failures in perception, memory, and motor function, the most plausible view is that cognitive failure makes a person vulnerable to showing bad effects of stress, rather than itself resulting from stress.
StrokeClinical Correlates of White Matter Findings on Cranial Magnetic Resonance Imaging of 3301 Elderly People
1,473 Citations1996W. T. Longstreth, Teri A. Manolio +7 more
White matter findings were significantly associated with age, silent stroke, hypertension, FEV1, and income, and may not be considered benign because they are associated with impaired cognitive and lower extremity function.
European Journal of EpidemiologyDeterminants of disease and disability in the elderly: The Rotterdam elderly study
1,141 Citations1991Albert Hofman, Diederick E. Grobbee +2 more
TheRotterdam Elderly Study is a prospective follow-up study, in which determinants of disease and determintants of progression of disease will be investigated in the total population of 55 years or over of the district of Ommoord in Rotterdam.
NeurologyCerebral white matter lesions, vascular risk factors, and cognitive function in a population‐based study
1,002 Citations1994Monique M.B. Breteler, John C. van Swieten +9 more
It is suggested that classic cardiovascular risk factors, as well as thrombogenic factors, are associated with white matter lesions in subjects over 65 years of age in the general population, and that these lesions may be related to cognitive function.
Annals of NeurologyCerebral white matter lesions and cognitive function: The Rotterdam scan study
889 Citations2000Jan Cees de Groot, Frank‐Erik de Leeuw +5 more
Tasks that involve speed of cognitive processes appear to be more affected by WMLs than memory tasks, and subjects with most severe periventricular W MLs performed nearly 1 SD below average on tasks involving psychomotor speed, and more than 0.5SD below average for global cognitive function.
Annals of NeurologyCerebral white matter lesions and cognitive function: The Rotterdam scan study
729 Citations2000Jan Cees de Groot, Frank‐Erik de Leeuw +5 more
Tasks that involve speed of cognitive processes appear to be more affected by WMLs than memory tasks, and subjects with most severe periventricular W MLs performed nearly 1 SD below average on tasks involving psychomotor speed, and more than 0.5SD below average for global cognitive function.
Psychological MedicineA semi-structured clinical interview for the assessment of diagnosis and mental state in the elderly: the Geriatric Mental State Schedule: I. Development and reliability
706 Citations1976J. R. M. Copeland, Michael Kelleher +5 more
A standardized, semi-structured interview for examining and recording the mental state in elderly subjects is described, which allows the classification of patients by symptom profile and can demonstrate changes in that profile over time.
NeurologyThe effect of white matter hyperintensity volume on brain structure, cognitive performance, and cerebral metabolism of glucose in 51 healthy adults
538 Citations1995Charles DeCarli, Declan Murphy +9 more
WMHI volume is associated with structural and functional brain changes even within a group of very healthy individuals and is related to elevated systolic blood pressure even when it is within the normal age-related range.
PubMedCerebral MR venography: normal anatomy and potential diagnostic pitfalls.
440 Citations2000R. H. Ayanzen, C R Bird +4 more
Transverse sinus flow gaps can be observed in as many as 31% of patients with normal MR imaging findings; these gaps should not be mistaken for dural sinus thrombosis.
Archives of General PsychiatryCerebral White Matter Lesions and Depressive Symptoms in Elderly Adults
433 Citations2000Jan Cees de Groot, Frank‐Erik de Leeuw +4 more
The severity of subcortical white matter lesions is related to the presence of depressive symptoms and to a history of late-onset depression.
The Journal of General PsychologyLearning and Retrieval Rate of Words Presented Auditorily and Visually
428 Citations1985Nico Brand, J. Jolles
An experiment was carried out using normal subjects, in which the effects of presentation mode and order of modality were investigated, and there were no differential effects of these variables on several parameters, such as the number of words recalled and the learning curve.
Archives of NeurologyWhite Matter Changes in Healthy Elderly Persons Correlate With Attention and Speed of Mental Processing
422 Citations1993Raija Ylikoski, Ari Ylikoski +4 more
Mild LA in normal aged subjects could explain some of the intellectual impairment in the elderly, especially that of slowing of distinct motor and attentional functions, as well as slowing of mental processing.
NeurologySubjective memory complaints may announce dementia
340 Citations1996Ben Schmand, Cees Jonker +2 more
It is concluded that subjective memory complaints may predict dementia within 3 years, particularly when there are objective signs of memory deterioration.
StrokeRelationship Between ApoE, MRI Findings, and Cognitive Function in the Cardiovascular Health Study
310 Citations1998Lewis H. Kuller, Lynn Shemanski +7 more
It is demonstrated that vascular changes on MRI, measures of brain atrophy, ApoE-4, and age, education, and race are associated with low cognitive scores among older individuals.
Archives of NeurologyMemory Complaints in Older Adults
295 Citations1991Karen I. Bolla
It was showed that self-rating of memory disturbance by older adults may be related more to depressed mood than to poor performance on memory tests.
American Journal of PsychiatryAssociation of subjective memory complaints with subsequent cognitive decline in community-dwelling elderly individuals with baseline cognitive impairment
246 Citations1997Peter W. Schofield, Karen Marder +3 more
Memory complaints may lack validity in subjects with normal cognition, but in nondemented individuals with cognitive impairment, memory complaints may predict subsequent cognitive decline.
The British Journal of PsychiatryA Magnetic Resonance Imaging Study of White Matter Lesions in Depression and Alzheimer's Disease
239 Citations1996John T. O’Brien, Patricia Desmond +4 more
An association between DWML and depression and PVL and Alzheimer's disease is supported and the increase with DWML that occurs with ageing may predispose some elderly subjects to depression.
Archives of General PsychiatryMemory Complaints and Impairment in Normal, Depressed, and Demented Elderly Persons Identified in a Community Survey
228 Citations1990Daniel O’Connor
The Journals of Gerontology Series AThe Relation Between Morbidity and Cognitive Performance in a Normal Aging Population
217 Citations1998Martin P.J. van Boxtel, Frank Buntinx +4 more
Existing morbidity as a whole contributes only modestly to total variance in cognitive function, however, some specific, relatively common diseases of the elderly, such as diabetes and chronic bronchitis, may aggravate the age-related decline in cognitive ability.
Annals of NeurologyA follow-up study of blood pressure and cerebral white matter lesions
192 Citations1999Frank‐Erik de Leeuw, Jan Cees de Groot +5 more
The results indicate that the J‐shape relationship of diastolic blood pressure is not restricted to cardiovascular disease, but is also manifest in cerebrovascular disease.
Archives of NeurologyScreening for Early Dementia Using Memory Complaints From Patients and Relatives
146 Citations1990Jeannette McGlone, S. B. Gupta +4 more
Factor analysis indicated that patients' memory complaints correlated with depression rather than objective memory performance, while relatives' ratings correlated with objective memory scores, not depression.
American Journal of RoentgenologyDural sinus thrombosis: findings on CT and MR imaging and diagnostic pitfalls.
122 Citations1998James M. Provenzale, Giji Joseph +1 more
Clinical GeneticsApolipoprotein E<sup>4</sup>allele in the normal elderly: neuropsychologic and brain MRI correlates
103 Citations1996Helena Schmidt, Reinhold Schmidt +5 more
It is concluded that the apolipoprotein E e4 allele is associated with subtle learning and memory deficits in normal elderly persons and may therefore be suggested a marker for accelerated cognitive aging.
Brain and CognitionRigorous health screening reduces age effect on memory scanning task
102 Citations1991Peter J. Houx, Fred W. Vreeling +1 more
The results of the present study make a reasonable case for the view that many age effects reported in the literature can be largely explained by suboptimal brain functioning, i.e., by other factors than aging per se.
Acta Neurologica ScandinavicaThe influence of white matter lesions on neuropsychological functioning in demented and non-demented 85-year-olds
90 Citations2009Ingmar Skoog, Stig Berg +3 more
It is concluded that white matter lesions contribute to cognitive decline in both non‐demented and demented elderly subjects.
European NeurologyDiagnosis of Cerebral Venous Thrombosis with Routine Magnetic Resonance: An Update
88 Citations1998Daniele Bianchi, P. Maeder +3 more
The type of signal abnormalities, the different types of clot- and flow-related artefacts, and the indirect signs of cerebral venous thrombosis are described.
Archives of NeurologyThe Validity of New Memory Complaints in the Elderly
86 Citations1997Peter W. Schofield, Diane M. Jacobs +3 more
New MCs from individuals, who when without dementia recently denied MCs, may suggest the presence of significant impairment of memory or cognition.
Psychological MedicineDepression, APOE genotype and subjective memory impairment: a cross-sectional study in an African-Caribbean population
86 Citations2001Robert Stewart, C Russ +4 more
Depression may not be a sufficient explanation for subjective memory complaints and memory complaints in the presence of depression are associated with high prevalence of ε4 and therefore, presumably, a raised risk of subsequent dementia.
American Journal of PsychiatryMemory Self-Appraisal in Middle-Aged and Older Adults With the Apolipoprotein E-4 Allele
77 Citations1999Gary W. Small, Stephen T. Chen +13 more
The APOE-4 allele is associated with increased subjective memory impairment in middle-aged and older adults and longitudinal studies of age-related memory loss should include genetic risk and subjective memory measures as potential predictors of decline.
NeuroradiologyCommon variations of the lateral and occipital sinuses at the confluens sinuum
71 Citations1980F. Dora, Turgút Zileli
Additional variations of the lateral and occipital sinuses in the confluent sinuum were discovered in this study.
Journal of neural transmission. SupplementumCognitive correlates of cerebral white matter changes
68 Citations1998Jan Cees de Groot, F.E. de Leeuw +1 more
Changes in the white matter of the brain appear in both normal and cognitively impaired elderly individuals and are common in demented patients.
The Journals of Gerontology Series AThe joint effect of apolipoprotein E epsilon4 and MRI findings onlower- extremity function and decline in cognitive function
65 Citations2000Dorit Carmelli, Charles DeCarli +5 more
The joint effect of radiological findings and the ApoE-epsilon4 allele on cognitive decline and lower-extremity function was often greater than that expected from the separate effects combined.
BMJRaised blood pressure and plasma noradrenaline concentrations in teenagers and young adults selected from an open population.
60 Citations1979Albert Hofman, Frans Boomsma +2 more
A positive association between PNA concentrations and age was observed in the controls but not the subjects with hypertension, owing to the higher concentrations in younger hypertensive subjects.
Dementia and Geriatric Cognitive DisordersWhite Matter Lesions in Alzheimer Patients Are Influenced by Apolipoprotein E Genotype
57 Citations1999Lena Bronge, Sven‐Erik Fernaeus +5 more
The results could imply that in APOE allele σ4 carriers, the WMLs represent a pathological process related to the aetiology of the disease.
Neurobiology of AgingMRI and genetic correlates of cognitive function in elders with memory impairment
48 Citations2001David Bartrés‐Faz, Carme Junqué +9 more
The present study investigated the relationship between genetic variation, MRI measurements and neuropsychological function in a sample of 58 elders exhibiting memory decline and found an association between the A allele of the apolipoprotein C1 (APOC1) polymorphism and poorer memory and frontal lobe function.
European NeurologyCognitive Functions in Subjects with Incidental Cerebral Hyperintensities
43 Citations2008Toshiya Fukui, Koujiro Sugita +3 more
It is suggested that disturbances in attention and speed may initially result from incidental hyperintensities found by magnetic resonance imaging, while other cognitive functions remain unaffected.
Annals of Otology Rhinology & LaryngologyNarrow and Atretic Transverse Dural Sinuses: Clinical Significance
27 Citations1973Harry A. Kaplan, Ann A. Browder +1 more
In 422 specimens of cerebral dural sinuses obtained at autopsy, there were 13 with marked narrowing of a segment of one or the other transverse sinuses, and 11 with absence of a part or all of a transverse Sinus.