Endocrine responses to mother‐infant separation in developing rats
Developmental PsychobiologyPublished 1 July 1990
Cynthia M. Kuhn, John Pauk, Saul M. Schanberg
Citations242
SJR quartileQ2
SJR score0.87
SNIP0.76
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TL;DR
It is reported that growth hormone secretion falls rapidly immediately upon separation of pups from the dam, while robust rises in corticosterone secretion are delayed for many hours, and growth hormone responses are observed earlier in ontogeny.
Abstract
Separation of neonatal rat pups from the dam have been reported to elicit two endocrine responses in the pup: a fall in growth hormone secretion and a rise in corticosterone secretion. However, the temporal, ontogenetic, and behavioral determinants of these responses have not been compared. In the present study, we report that these two responses can be differentiated on each of these criteria. Growth hormone secretion falls rapidly immediately upon separation of pups from the dam, while robust rises in corticosterone secretion are delayed for many hours. In addition, growth hormone responses are observed earlier in ontogeny. Finally, active maternal behavior is required for normal growth hormone secretion in 10-day-old rat pups, while passive sensory stimuli associated with the dam can significantly reduce the corticosterone response to separation.
Keywords
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