A "New" Antigen in Leukemia Sera

JAMAPublished 15 February 1965

Baruch S. Blumberg

DOI10.1001/jama.1965.03080070025007

Source URL

Citations1,303

SJR quartileQ1

SJR score5.35

SNIP10.71

TL;DR

Patients who receive large numbers of transfusions for anemia and other causes may develop precipitins in their blood, which were thought to be antibodies against serum lipoproteins which developed in the patients as a result of the repeated transfusions.

Abstract

Patients who receive large numbers of transfusions for anemia and other causes may develop precipitins in their blood. These precipitins may react in agar gel double diffusion experiments with specific human serum lipoprotein found in the blood of other individuals. Since these precipitins were found only in patients who had received transfusions they were thought to be antibodies against serum lipoproteins which developed in the patients as a result of the repeated transfusions. The precipitin is referred to as an isoprecipitin since it develops against a specificity found in an individual from the same species. The antilipoprotein isoprecipitin1,2developed in approximately 30% of 47 patients with thalassemia who had received transfusions. Isoprecipitins also developed in smaller number of transfused patients with other diseases. All precipitins stained with sudan black, a dye specific for lipid. Immunoelectrophoretic and ultracentrifugal studies showed that the protein with which the isoprecipitins reacted was a

Keywords

Medicine

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