Prostaglandin D2 inhibits the aggregation of human platelets
Thrombosis ResearchPublished 1 September 1974
J. Bryan Smith, Melvin J. Silver, Carol M. Ingerman, James J. Kocsis
Citations225
SJR quartileQ2
SJR score0.97
SNIP1.03
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
Prostaglandin D2, heretofore considered to be biologically inactive, was found to be more than twice as potent as prostaglandsin E1 as an inhibitor of aggregation in human citrated platelet-rich plasma.
Abstract
Prostaglandin D2, heretofore considered to be biologically inactive, was found to be more than twice as potent as prostaglandin E1 as an inhibitor of aggregation in human citrated platelet-rich plasma. It was much less potent than prostaglandin E1 in rabbit or rat platelet-rich plasma. This prostaglandin, or a derivative of it, may prove to be of greater value than prostaglandin E1 in maintaining the viability of stored platelets and as an antithrombotic agent.
Keywords
Medicine
Proceedings of the National Academy of SciencesIsolation and Structure of Two Prostaglandin Endoperoxides That Cause Platelet Aggregation
998 Citations1974Mats Hámberg, Jan Svensson +2 more
Platelet aggregation induced by thrombin was accompanied by release of material reducible by stannous chloride into prostaglandin F(2alpha), thus indicating the involvement of endogenous prostaglandsin endoperoxides in platelet aggregation.
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid MetabolismIsolation and properties of intermediates in prostaglandin biosynthesis
795 Citations1973D.H. Nugteren, E. Hazelhof
The finding that prostaglandin R can be converted enzymatically into the biologically inactive prostaglandsin D in good yields, reveals a new pathway in prostag landin metabolism and postulates the key position of prostag Landin R as the first biologically active product formed from essential fatty acids.
Proceedings of the National Academy of SciencesDetection and Isolation of an Endoperoxide Intermediate in Prostaglandin Biosynthesis
644 Citations1973Mats Hámberg, Bengt Samuelsson
The smooth muscle-stimulating activity of the endoperoxide ester on the isolated rabbit aortas trip was 4- to 8-times higher than that of the methyl ester of prostaglandin E(2).
Journal of Lipid ResearchProstaglandins and related factors: XIX. Thin-layer chromatography of prostaglandins
483 Citations1964Krister Gréen, Bengt Samuelsson
Journal of Clinical InvestigationFormation of an Intermediate in Prostaglandin Biosynthesis and Its Association with the Platelet Release Reaction
201 Citations1974J. Bryan Smith, Carol M. Ingerman +2 more
A compound that could be converted to prostaglandin F(2alpha) by mild chemical reduction was formed by human platelets in response to arachidonic acid, collagen, or L-epinephrine and may be a trigger for the platelet release reaction.
Journal of Clinical InvestigationFormation of Prostaglandins during the Aggregation of Human Blood Platelets
178 Citations1973J. Bryan Smith, Carol M. Ingerman +2 more
It is suggested that the formation and release of prostaglandins is associated with the secretion of endogenous ADP and 5-hydroxytryptamine.
BMJEffect of prostaglandin E1 on platelet behaviour in vitro and in vivo.
176 Citations1967P.R. Emmons, J R Hampton +3 more
In vitro studies done on blood taken from healthy volunteers showed that prostaglandin (PG) E1 consistently inhibited platelet-to-glass adhesiveness significantly and in vivo studies conducted in rabbits showed that PGE1 suppressed platelet thrombosis formation.
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid MetabolismRelationship between chemical structure and plateletaggregation activity of prostaglandins
176 Citations1969J. Kloeze
It has been found that the CO groups at the ring and in the carboxyl group, as well as the distance between them, are essential, as is the hydroxyl group at C-15.
NatureMembrane Active Drugs and the Aggregation of Human Blood Platelets
174 Citations1967D. C. B. Mills, Gordon C. K. Roberts
Nature New BiologyEffect of Prostaglandin E2 and Aspirin on the Secondary Aggregation of Human Platelets
99 Citations1972Hideo Shio, Peter W. Ramwell
A lack of cellular specificity1 of the prostaglandins creates potential hazards in their use as therapeutic agents: one associated with PGE2 and the reversal of the effect with aspirin are described.
British Journal of HaematologyThe Effect of Prostaglandin E<sub>1</sub> on Platelet Function <i>in Vitro</i> and <i>in Vivo</i>
88 Citations1970R L Kinlough-Rathbone, MA Packham +1 more
It is concluded that the effect of PGE1 on haemostasis involves inhibition of the release of ADP from platelets exposed to collagen and thrombin, and inhibition ofADP‐induced aggregation.
BJOG An International Journal of Obstetrics & GynaecologyTERMINATION OF SECOND TRIMESTER PREGNANCY WITH 15 METHYL ANALOGUES OF PROSTAGLANDINS E<sub>2</sub>, AND F<sub>2x</sub>
80 Citations1972S.M.M. Karim, Santosh Sharma
The uterine muscle stimulating activities of the 15‐methyl analogues of naturally occurring prostaglandins E2, and F2α, in the second trimester of pregnancy have been investigated and the human uterine Muscle stimulating potencies and duration of actions of these compounds are greatly increased.
ScienceProstaglandin E <sub>1</sub> in Platelet Harvesting: An in vitro Study
46 Citations1972Hideo Shio, Peter W. Ramwell
Prostaglandin E1 (10-8 to 1O-7 molar) is effective in improving the preparation of human platelet concentrates from plasma rich in platelets and from whole blood.
ScienceProstaglandins in the Preparation of Blood Components
35 Citations1972C. R. Valeri, C. G. Zaroulis +3 more
The hemostatic effectiveness of platelets treated with prostaglandin was shown to be normal in man and the recovery in vivo and the life-span values of the platelets were not altered.
Scandinavian Journal of Clinical and Laboratory InvestigationProstaglandins in Platelet Aggregation
29 Citations1969E. Irion, Margareta Blombäck
The inhibitory effect of different prostaglandins on ADP-induced platelet aggregation has been studied using a technique similar to that of Born and O'Brien and PGE 1 has a high inhibiting capacity while PGE 2 shows about one-fifth of that.