Actin expression in smooth muscle cells of rat aortic intimal thickening, human atheromatous plaque, and cultured rat aortic media.
Journal of Clinical InvestigationPublished 1 January 1984Open access
Giulio Gabbiani, Olivier Kocher, W S Bloom, Joël Vandekerckhove, K. Weber
Citations333
SJR quartileQ1
SJR score4.72
SNIP2.17
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TL;DR
This pattern of actin expression represents a new reliable protein-chemical marker of experimental and human atheromatous smooth muscle cells and is presented as a novel marker of rat and human aortic intimal thickening.
Abstract
Actin of smooth muscle cells of rat and human aortic media shows a predominance of the alpha-isoform. In experimental rat aortic intimal thickening, in human atheromatous plaque, and in cultured aortic smooth muscle cells, there is a typical switch in actin expression with a predominance of the beta-form and a noticeable amount of gamma-form. This pattern of actin expression represents a new reliable protein-chemical marker of experimental and human atheromatous smooth muscle cells.
Keywords
Biochemistry, Genetics and Molecular Biology
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