Splitting vessels: Keeping lymph apart from blood
Nature MedicinePublished 31 January 2003
Shahin Rafii, Mihaela Skobe
Citations268
SJR quartileQ1
SJR score18.33
SNIP8.71
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
It seems that two signaling molecules expressed mainly in hematopoietic cells segregate lymphatic and blood vessels during development and tissue revascularization.
Abstract
Mixing lymph and blood in the vascular system can have dramatic effects on health, but how these two systems remain separate has been unclear. Now, it seems that two signaling molecules expressed mainly in hematopoietic cells segregate lymphatic and blood vessels during development and tissue revascularization.
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
Nature MedicineImpaired recruitment of bone-marrow–derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth
1,852 Citations2001David Lyden, Koichi Hattori +18 more
It is demonstrated that recruitment of VEGF-responsive BM-derived precursors is necessary and sufficient for tumor angiogenesis and suggested new clinical strategies to block tumor growth are suggested.
CellProx1 Function Is Required for the Development of the Murine Lymphatic System
1,581 Citations1999Jeffrey T. Wigle, Guillermo Oliver
It is reported that the homeobox gene Prox1 is expressed in a subpopulation of endothelial cells that by budding and sprouting give rise to the lymphatic system, suggesting that unidentified guidance signals regulate this process.
Cancer CellMolecular mechanisms of lymphangiogenesis in health and disease
727 Citations2002Kari Alitalo, Peter Carmeliet
The recent discovery of the key lymphangiogenic factors VEGF-C and V EGF-D and their receptor VEGFR-3 has allowed novel insights into how the lymphatic vessels and blood vessels coordinately grow and affect human disease.
Nature reviews. CancerVascular and haematopoietic stem cells: novel targets for anti-angiogenesis therapy?
677 Citations2002Shahin Rafii, David Lyden +3 more
CellA Role for Hematopoietic Stem Cells in Promoting Angiogenesis
505 Citations2000Nobuyuki Takakura, Toshio Watanabe +6 more
It is shown that hematopoietic stem cells (HSCs) play important roles for angiogenesis during embryogenesis and the role of HSCs in endothelial cell (EC) development is investigated.
ScienceRegulation of Blood and Lymphatic Vascular Separation by Signaling Proteins SLP-76 and Syk
414 Citations2003Farhad Abtahian, Anastasia Guerriero +13 more
A hematopoietic signaling pathway required for separation of the two major vascular networks in mammals is revealed, and blood-lymphatic connections lead to embryonic hemorrhage and arteriovenous shunting.
Immunology TodayTyrosine kinase SYK: essential functions for immunoreceptor signalling
393 Citations2000Martin Turner, Edina Schweighoffer +3 more
Gene-targeting studies have identified the cell types that require SYK for development and function, and the receptors that use SYK as well as their downstream signalling effectors.
Genes & DevelopmentThe rediscovery of the lymphatic system: old and new insights into the development and biological function of the lymphatic vasculature
375 Citations2002Guillermo Oliver, Michael Detmar
The lymphatic system is composed of a vascular network of thin-walled capillaries that drain protein-rich lymph from the extracellular spaces within most organs, and lymphatic vessels are not normally present in avascular structures such as epidermis, hair, nails, cartilage, and cornea.
Microscopy Research and TechniqueLymphatic function, lymphangiogenesis, and cancer metastasis
184 Citations2001Melody A. Swartz, Mihaela Skobe
The unique structural and functional characteristics of the lymphatic vessels that render them particularly suitable for invasion by tumor cells and for their efficient transport to lymph nodes are described.
Journal of Clinical InvestigationFetal hemorrhage and platelet dysfunction in SLP-76–deficient mice
169 Citations1999James L. Clements, Jong Ran Lee +7 more
Fetal hemorrhage and perinatal mortality in SLP-76-deficient mice are described and data are revealed that SLp-76 expression is required for optimal receptor-mediated signal transduction in platelets as well as T lymphocytes.
Proceedings of the Fourth International Symposium on Polarization Phenomena in Nuclear ReactionsLymphangiogenesis: Mechanisms, significance and clinical implications
119 Citations1997Marlys H. Witte, Dennis Way +2 more
An arc of the circulatory system on the dark side of the blood-tissue interface and its growth (“lymphangiogenesis”) has received scant attention even though lymphatic (re)generation is both vigorous and essential, and disorders of lymphatic dynamics are common.
ImmunityDifferential Requirement for SLP-76 Domains in T Cell Development and Function
100 Citations2001Peggy Myung, Geo Derimanov +8 more
Examination of mice expressing various mutants of SLP-76 on the null background demonstrates a differential requirement for specific domains of SLp-76 in thymocytes and T cells and provides new insight into the molecular mechanisms underlying SL P-76 function.
BloodSyk expression in endothelial cells and their morphologic defects in embryonic Syk-deficient mice
59 Citations2001Shigeru Yanagi, Ryoko Inatome +4 more
A critical role for Syk is shown in endothelial cell function and in maintaining vascular integrity in vivo and electron microscopic analysis of Syk-deficient mice revealed an abnormal morphogenesis and a decreased number of endothelial cells.
