Interaction of DNA and liposomes as a model for membrane-mediated DNA damage
NaturePublished 1 May 1977
Dennis Pietronigro, Walis Jones, KATHY KALTY, Harry B. Demopoulos
Citations63
SJR quartileQ1
SJR score18.29
SNIP10.16
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TL;DR
The damaging consequences to the biological activity of bacterial transforming DNA in such a system are reported and may be relevant to several pathological processes, including carcinogenesis, ageing, ageing8 and oxygen-dependent, radiation-induced cell lethality.
Abstract
WE have described the antioxidant activity of calf thymus DNA on the oxidation of liposomal suspensions1; we now report the damaging consequences to the biological activity of bacterial transforming DNA in such a system. Because DNA is associated with eukaryotic2 and bacterial cell membranes3, the DNA–membrane interaction described here may be relevant to several pathological processes, including carcinogenesis4–7, ageing8–11 and oxygen-dependent, radiation-induced cell lethality10,11. In the presence of oxygen, the unsaturated fatty chains of membrane phospholipid undergo autoxidation12. These autocatalytic free radical reactions, due to their chain nature, both amplify and propagate an initiating event occurring within the membrane, during which time many highly reactive and potentially damaging chemical species are formed13.
Keywords
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