The role and structure of mitochondrial carriers
FEBS LettersPublished 10 March 2004
Edmund R.S. Kunji
Citations157
SJR quartileQ1
SJR score1.22
SNIP0.77
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TL;DR
The projection structure of the yeast ADP/ATP carrier by electron crystallography shows that carriers could form homo‐dimers in the membrane, inconsistent with the consensus that mitochondrial carriers exist as homo-dimers.
Abstract
Members of the mitochondrial carrier family transport compounds over the inner mitochondrial membrane to link the biochemical pathways in the cytosol with those in the mitochondrial matrix. X-ray crystallography has recently provided us with the first atomic model of the bovine ADP/ATP carrier, which is a member of this family. The structure explains the typical three-fold sequence repeats and signature motif of mitochondrial carriers. However, the carrier was crystallised as a monomer in detergent, which is inconsistent with the consensus that mitochondrial carriers exist as homo-dimers. The projection structure of the yeast ADP/ATP carrier by electron crystallography shows that carriers could form homo-dimers in the membrane.
Keywords
Biochemistry, Genetics and Molecular Biology
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