Neuronal Loss in Hippocampus Induced by Prolonged Ethanol Consumption in Rats
SciencePublished 8 August 1980
Don W. Walker, David E. Barnes, Steven F. Zornetzer, Bruce E. Hunter, Patricia Kubanis
Citations397
SJR quartileQ1
SJR score10.42
SNIP6.62
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TL;DR
This study provides direct evidence that long-term ethanol consumption, in the absence of malnutrition, produces neuronal loss in the central nervous system.
Abstract
Quantitative neurohistological techniques were used to examine the hippocampal complex of laboratory rats maintained on ethanol-containing or control diets for 5 months followed by a 2-month alcohol-free period. Chronic ethanol consumption resulted in a significant loss of hippocampal pyramidal and dentate gyrus granule cells. This study provides direct evidence that long-term ethanol consumption, in the absence of malnutrition, produces neuronal loss in the central nervous system.
Keywords
Neuroscience
Central Nervous System
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