Alanine aminopeptidase activities in cancerous and non-cancerous human breast tissues.

Alanine aminopeptidase activity in cancerous and non-cancerous human breast tissues of the same patients using the method described by Sidorowicz et al. (2) is measured to test this hypothesis and elucidate possible molecular mechanisms.

Abstract

In the light of this suggestion, we measured the activity of the enzyme in cancerous and non-cancerous human breast tissues to test this hypothesis and to elucidate possible molecular mechanisms. For this propose, we measured alanine aminopeptidase activity in 16 cancerous and 16 non-cancerous human breast tissues of the same patients using the method described by Sidorowicz et al. (2). However, we found no difference between the activities (X ± SD) of alanine aminopeptidase in cancerous (0.101 ± 0.045 U/mg) and non-cancerous (0.092 ± 0.049 U/mg) human breast tissues (Student's t-test, p < 0.25, n. s.). We neither found any correlation between alanine aminopeptidase activities of both tissues (r = 0.034).