Expression of heat shock proteins (HSP27, HSP60, HSP70, HSP90, GRP78, GRP94) in hepatitis B virus-related hepatocellular carcinomas and dysplastic nodules
World Journal of GastroenterologyPublished 1 January 2005Open access
Seung Oe Lim
Citations151
SJR quartileQ1
SJR score1.42
SNIP1.38
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TL;DR
The expressions of HSPs are commonly up-regulated in HBV-related HCCs and GRP78 might play an important role in the stepwise progression of HBV -related hepatocarcinogenesis, strongly suggesting vascular invasion and intrahepatic metastasis.
Abstract
The expressions of HSPs are commonly up-regulated in HBV-related HCCs and GRP78 might play an important role in the stepwise progression of HBV-related hepatocarcinogenesis. GRP78, GRP94, and HSP90 may be important prognostic markers of HBV-related HCC, strongly suggesting vascular invasion and intrahepatic metastasis.
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
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Critical Reviews in Eukaryotic Gene ExpressionThe Glucose-Regulated Proteins (GRP78 and GRP94): Functions, Gene Regulation, and Applications
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The knowledge of GRPs as molecular chaperones is rapidly evolving and it is anticipated that the GRPs will make special contributions in the areas of basic cell biology, biotechnology, and cancer biology, where they may play a role as the prototype of a class of genes that are regulated by signal transduction pathways originating in the ER and traveling to the nucleus.
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