Prevention of Pneumocystis carinii pneumonia
AIDSPublished 1 August 1997
Sandra Schwarcz, Mitchell H. Katz, A. Hirozawa, Jan Gurley, George F. Lemp
Citations21
SJR quartileQ1
SJR score1.21
SNIP0.90
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TL;DR
Barriers to receipt of PCP prophylaxis exist and are resulting in cases of preventable disease and unnecessary medical costs, and interventions to increase counseling, testing, and referral to medical care for persons at high risk for HIV infection are needed.
Abstract
Barriers to receipt of PCP prophylaxis exist and are resulting in cases of preventable disease and unnecessary medical costs. Interventions to increase counseling, testing, and referral to medical care for persons at high risk for HIV infection are needed.
Keywords
Medicine
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Development of P carinii pneumonia was associated with the stage of Kaposi's sarcoma, B subtype disease, and the presence of 0.20 × 109/L (200/mm 3 ) or fewer CD4 cells at study entry.
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299 Citations1995Richard E. Chaisson, Jeanne Keruly +1 more
In the entire cohort, a lower CD4 cell count, a diagnosis of AIDS, older age, and the receipt of antiretroviral therapy before enrollment were associated with an increased risk of death, whereas the use of prophylaxis against pneumocystis pneumonia, zidovudine use after enrollment, and having a job at base line wereassociated with lower risks of death.
New England Journal of MedicineAerosolized Pentamidine for Prophylaxis against<i>Pneumocystis carinii</i>Pneumonia
295 Citations1990Gifford Leoung, David W. Feioal +9 more
Aerosolized pentamidine was effective for prophylaxis against PCP in patients infected with HIV, according to the dose and schedule of administration and it and zidovudine were well tolerated together and had independentProphylactic benefits.
New England Journal of MedicineA Controlled Trial of Aerosolized Pentamidine or Trimethoprim–Sulfamethoxazole as Primary Prophylaxis against<i>Pneumocystis carinii</i>Pneumonia in Patients with Human Immunodeficiency Virus Infection
280 Citations1992M. M. E. Schneider, Andy I. M. Hoepelman +7 more
For patients with HIV infection, trimethoprim-sulfamethoxazole taken once a day is more effective as primary prophylaxis against PCP than aerosolized pentamidine administered once a month, although adverse drug reactions are more frequent with trimethobrim- sulfamETHoxazol.
New England Journal of MedicineA Controlled Study of Inhaled Pentamidine for Primary Prevention of<i>Pneumocystis carinii</i>Pneumonia
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A dose of 300 mg of aerosolized pentamidine given every four weeks was well tolerated and 60 to 70 percent effective in preventing a first episode of PCP in patients with HIV infection.
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The results suggest that the shorter survival of women may be a result of factors other than gender, possibly including less use of antiretroviral therapy.
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In these estimates, the total medical costs of treating ARC patients could approach one-half of the cost of treating AIDS patients by 1991, primarily due to costs associated with AZT.
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55 Citations1991Kenneth A. Freedberg, Anna N.A. Tosteson +2 more
A decision-analytic model concludes that initial prophylaxis with either dapsone or trimethoprim-sulfamethoxazole is most cost effective, with an incremental cost-effectiveness ratio of $13,400 per life year saved compared with no proPHylaxis.
JAIDS Journal of Acquired Immune Deficiency SyndromesHealth Care Delivery, Zidovudine Use, and Survival of Women and Men with AIDS
53 Citations1994Barbara J. Turner, Leona E. Markson +3 more
Health care delivery and drug therapy in the year before AIDS diagnosis for continuously enrolled New York State Medicaid beneficiaries with AIDS in 1988–1990 was examined to define predictors of survival for women and men after AIDS diagnosis.
American Journal of EpidemiologyThe Spectrum of Medical Conditions and Symptoms before Acquired Immunodeficiency Syndrome in Homosexual and Bisexual Men Infected with the Human Immunodeficiency Virus
49 Citations1995Scott D. Holmberg, Susan Buchbinder +6 more
Many medical problems, some not widely appreciated, occur in HIV-infected men before they develop AIDS-defining illnesses, signifying considerable morbidity from pre-AIDS HIV infection.
AIDSLow-dose dapsone prophylaxis of Pneumocystis carinii pneumonia in AIDS and AIDS-related complex
47 Citations1990Carol A. Kemper, Richard Tucker +5 more
A review of 33 patients at the authors' institution with a history of PCP who received no prophylaxis demonstrated seven relapses, three of which were fatal, and cost analysis revealed a significant advantage for oral dapsone over aerosolized pentamidine.
CHEST JournalThe Impact of Prophylaxis on Outcome and Resource Utilization in Pneumocystis carinii Pneumonia
26 Citations1995Joel E. Gallant, Sharon M. McAvinue +4 more
Patients who developed PCP despite prophylaxis had a better outcome and used fewer resources than patients not receiving preventive therapy, and this study emphasizes the impact of PCP proPHylaxis on the morbidity, mortality, and economics of HIV health care.
Annals of Internal MedicineCoping with HIV Infection: Why People Delay Care
14 Citations1992Mitchell H. Katz, Andrew B. Bindman +1 more
This work investigated factors associated with delay in initiating care until their disease is advanced with HIV in persons infected with the human immunodeficiency virus.
AIDSAerosolized pentamidine as primary prophylaxis for Pneumocystis carinii pneumonia
10 Citations1994Christer Lidman, Ove Berglund +3 more
Clinical check-ups and treatment of acute PCP could be a justifiable alternative to drug prophylaxis with aerosolized pentamidine in selected patients and could not detect any major effect on mortality and morbidity.
PubMedSeverity and outcome of Pneumocystis carinii pneumonia (PCP) in patients of known and unknown HIV status.
10 Citations1994S. Mallal, O. P. Martinez +3 more
It is suggested that PCP is prevented or deferred in patients receiving care for HIV disease and is less severe as a result of early diagnosis and treatment.
Journal of General Internal MedicineHealth insurance and utilization inPneumocystis carinii pneumonia
6 Citations1995Sana Loue, Donald J. Slymen +2 more
To examine the relationship between health insurance status and health services utilization among HIV-infected patients with activePneumocystis carinii pneumonia (PCP), the discharge and outpatient databases of a large California medical facility were reviewed.
