Renal Tubular Acidosis, Glomerulonephritis and Immunologic Factors in Sjogren's Syndrome
Arthritis & RheumatismPublished 1 December 1968
Norman Talal, Elias Zisman, Peter H. Schur
Citations168
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
Urinary acidification was impaired in 6 of 12 patients with Sjogren's syndrome (SS) studied before and during the administration of ammonium chloride.
Abstract
Abstract Urinary acidification was impaired in 6 of 12 patients with Sjogren's syndrome (SS) studied before and during the administration of ammonium chloride. Renal tubular acidosis was overt in 3 patients and subclinical in 2. The sixth patient had glomerulonephritis. Precipitating antibodies to tissue antigens were studied in 70 patients with SS. The group with renal disease had the greatest reactivity, and the only reactivity to heat denatured DNA. None of the 70 patients reacted with native DNA, and only one with nucleoprotein.
Keywords
Medicine
The Journal of Experimental MedicineIMMUNOLOGICAL STUDIES CONCERNING THE NEPHRITIS OF SYSTEMIC LUPUS ERYTHEMATOSUS
882 Citations1967David Koffler, Peter H. Schur +1 more
The immunochemical evidence for the high specific activity of antinuclear antibodies and the association of DNA antigen with DNA antibody in glomeruli add further support for the antigen-antibody complex hypothesis for renal injury in systemic lupus erythematosus.
The American Journal of MedicineCryoglobulinemia—A clinical and laboratory study
680 Citations1966M. Meltzer, E. C. Franklin +3 more
The condition in these patients appears to fall most closely into the group of "connective tissue disorders," such as systemic lupus erythematosus, and the possible role of the cryoglobulins in the pathogenesis of the vascular and renal lesions is discussed.
The Journal of ImmunologyQuantitative Micro-Complement Fixation and Its Use in the Study of Antigenic Structure by Specific Antigen-Antibody Inhibition
654 Citations1961Eleanor Wasserman, Lawrence Levine
A quantitative micromethod for the estimation of C' fixation is described, capable of measuring antigens in millimicrogram quantities, and specifically illustrated by the quantitative inhibition of pneumococcus polysaccharide immune systems by oligosaccharides.
New England Journal of MedicineImmunologic Factors and Clinical Activity in Systemic Lupus Erythematosus
596 Citations1968Peter H. Schur, John Sandson
Serial immunochemical observations may be useful in the management of patients with systemic lupus erythematosus, as they reflect the in vivo formation of immune complexes that cause nephritis.
Characteristics of a soluble nuclear antigen precipitating with sera of patients with systemic lupus erythematosus
552 Citations2001Eng M. Tan, Henry G. Kunkel
The American Journal of MedicineThe development of malignant lymphoma in the course of Sjögren's syndrome
514 Citations1964Norman Talal, Joseph J. Bunim
The hypothesis is presented that in Sjogren's syndrome the chronic state of immunologic hyperactivity and the proliferation of immunologically competent cells producing abnormal tissue antibodies predispose to the relatively frequent development of malignant lymphoma.
The Journal of ImmunologyCharacteristics of a Soluble Nuclear Antigen Precipitating with Sera of Patients with Systemic Lupus Erythematosus
482 Citations1966Eng M. Tan, Henry G. Kunkel
Sera of patients with systemic lupus erythematosus were demonstrated to contain precipitating antibodies to soluble tissue components other than DNA, and one dominant reaction was observed which was provisionally termed the Sm system.
The American Journal of MedicineExtrasalivary lymphoid abnormalities in Sjögren's syndrome (reticulum cell sarcoma, “pseudolymphoma,” macroglobulinemia)
319 Citations1967Norman Talal, Leon Sokoloff +1 more
These eight patients have certain clinical features in common with five patients described previously who had Sjogren's syndrome and reticulum cell sarcoma or pseudolymphoma, and these findings provide further evidence that Sjogsgren's syndrome predisposes to the development of extrasalivary lymphoid abnormalities.
Journal of Clinical InvestigationImpaired Lymphocyte Transformation and Delayed Hypersensitivity in Sjögren's Syndrome*
117 Citations1967Brigid G. Leventhal, Donald S. Waldorf +1 more
In vitro lymphocyte transformation in response to phytohemagglutinin and streptolysin O and in vivo skin sensitization to 2,4-dinitrochloro-benzene has been studied in patients with Sjögren's syndrome and in normal controls of comparable age and sex.
Experimental Biology and MedicineBentonite Flocculation Test for Rheumatoid Arthritis.
116 Citations1958J. Bozicevich, Joseph J. Bunim +2 more
When bentonite particles of a selected size are “sensitized” by human gamma globulin (Fraction II) and then mixed with serum from patients with rheumatoid arthritis, they flocculate.
Annals of the Rheumatic DiseasesOccurrence of antibody to salivary duct epithelium in Sjogren's disease, rheumatoid arthritis, and other arthritides. A clinical and laboratory study.
111 Citations1967R N MacSween, R. B. Goudie +8 more
The term "sicca syndrome" or 'sicca complex' is applied to those cases of Sj0gren's disease not associated with rheumatoid arthritis or other connective tissue disorders.
The American Journal of MedicineNephrogenic diabetes insipidus and other defects of renal tubular function in Sjögren's syndrome
108 Citations1965Martin A. Shearn, Wu-Hao Tu
Polyuria and polydipsia were the presenting symptoms in a young woman with Sjogren's syndrome and there were hyperchloremic acidosis with a defect in urinary acidification, increased clearance of phosphate and urate, and generalized aminoaciduria—a combination of findings compatible with the "adult Fanconi syndrome".
British Journal of Diseases of the ChestSjgren's syndrome
85 Citations1959U Bucher, Lynne Reid
At autopsy the lacrimal and salivary glands showed the characteristic atrophy of parenchyma with lymphatic infiltration, a similar picture being seen in the mucous glands of the bronchi and œsophagus.
The American Journal of MedicineRenal tubular acidosis after cadaver kidney homotransplantation
78 Citations1967Shaul G. Massry, Harry G. Preuss +2 more
The Journal of Experimental MedicineRENAL HOMOTRANSPLANTATION IN RATS
74 Citations1967Joseph D. Feldman, Sun Lee
The American Journal of MedicineClinical studies of hemolytic complement and the 11S component
67 Citations1967Lonnie B. Hanauer, Charles L. Christian
In subjects with systemic lupus erythematosus in remission, both 11S and C′ tended to be near normal, but slightly lowered C′ levels were not always reflected by 11S measurements, and current thoughts on the role of C′ in the pathogenesis of these conditions are reviewed.
Annals of Internal MedicineRenal Concentrating Defect in Sjögren's Syndrome
60 Citations1962Melvin Kahn, ARTHUR D. MERRITT +2 more
In the course of a recent study at the National Institutes of Health of the clinical and immunological abnormalities present in patients with Sjogren's syndrome (1-4), persistent hyposthenu...
Annals of the Rheumatic DiseasesAntinuclear and Precipitating Auto-antibodies in Sjögren's Syndrome
49 Citations1965J. Swanson Beck, John R. Anderson +3 more
The American Journal of MedicineRenal tubular acidosis
45 Citations1967I. Dodd Wilson, Ralph C. Williams +1 more
These three patients appear to represent an acquired form of renal tubular acidosis associated with familial elevations of serum immunoglobulin levels, especially IgG, generally clustered around the arithmetic mean for each sibling group.
Annals of Internal MedicineHyperglobulinemic Renal Tubular Acidosis
41 Citations1967Donna K. McCurdy, GIBBONS G. CORNWELL +1 more
Annals of Internal MedicineSystemic Lupus Erythematosus and Latent Renal Tubular Dysfunction
39 Citations1967Wu-Hao Tu, MARTIN A. SHEARN
Renal tubular acidosis, an impairment of renal acid excretion out of proportion to reduction of glomerular filtration rate, has been described in a variety of clinical settings.
The American Journal of MedicineMacroglobulinemic nephropathy
33 Citations1964Igor Luiz Argani, G. F. Kipkie
Australasian Annals of MedicineTHE ASSOCIATION OF RENAL TUBULAR ACIDOSIS WITH HYPERGLOBULINÆMIC PURPURA
26 Citations1962Alex Cohen, Bernard Way
Australasian Annals of MedicineLUPOID HEPATITIS: COMPUTER ANALYSIS DEFINING “HEPATITIS” AND “CIRRHOSIS” PHASES AND RELATIONSHIPS BETWEEN HEPATOCELLULAR DAMAGE AND IMMUNE REACTIONS IN THE LIVER
14 Citations1967Gideon Goldstein, IAN R. MACKAY