Breast cancer and breastfeeding: collaborative reanalysis of individual data from 47 epidemiological studies in 30 countries, including 50 302 women with breast cancer and 96 973 women without the disease
The LancetPublished 1 July 2002
Henrik Møller
Citations1,439
SJR quartileQ1
SJR score12.11
SNIP22.72
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TL;DR
The longer women breast feed the more they are protected against breast cancer, and the lack of or short lifetime duration of breastfeeding typical of women in developed countries makes a major contribution to the high incidence of breast cancer in these countries.
Abstract
The longer women breast feed the more they are protected against breast cancer. The lack of or short lifetime duration of breastfeeding typical of women in developed countries makes a major contribution to the high incidence of breast cancer in these countries.
Keywords
Social SciencesMedicine
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British Journal of CancerDesign and analysis of randomized clinical trials requiring prolonged observation of each patient. I. Introduction and design
2,312 Citations1976Richard Peto, Malcolm C. Pike +8 more
This report is the first simple account yet published for non-statistical physicians of how to analyse efficiently data from clinical trials of survival duration, and it may be preferable to use these statistical methods to study time to local recurrence of tumour, or toStudy time to detectable metastatic spread, in addition to studying total survival.
International Journal of CancerEstimates of the worldwide incidence of 25 major cancers in 1990
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Although women who have first-degree relatives with a history of breast cancer are at increased risk of the disease, most will never develop breast cancer, and most who do will be aged over 50 when their cancer is diagnosed.
New England Journal of MedicineLactation and a Reduced Risk of Premenopausal Breast Cancer
524 Citations1994Polly A. Newcomb, Barry E. Storer +7 more
Statistics in MedicineFloating absolute risk: An alternative to relative risk in survival and case‐control analysis avoiding an arbitrary reference group
437 Citations1991D.F. Easton, J Peto +1 more
The construction of standard errors for the parameters of all groups, without the need to select a baseline group, can be regarded as relating to roughly independent parameters, so that groups can be compared efficiently without knowledge of the covariances.
International Journal of CancerBreast-cancer risk following long-term oestrogen- and oestrogen-progestin-replacement therapy
416 Citations1999Cecilia Magnusson, John A. Baron +4 more
A positive association which was noted for use of oestrogen combined with testosterone‐derived progestins appeared especially pronounced with continuously combined regimens, which may substantially increase the incidence of post‐menopausal breast cancer, particularly among non‐obese women.
International Journal of CancerAssociation of menstrual and reproductive factors with breast cancer risk: Results from the Shanghai breast cancer study
298 Citations2000Yu-Tang Gao, Xiao‐Ou Shu +10 more
This study suggests that the changes in menstrual and reproductive patterns among women in Shanghai have contributed to the recent increase in breast cancer incidence, particularly among younger women.
Journal of Clinical EpidemiologyThe independent associations of parity, age at first full term pregnancy, and duration of breastfeeding with the risk of breast cancer
280 Citations1989Peter M. Layde, Linda A. Webster +4 more
Results do not support the supposed preeminent importance of age at first full-term pregnancy among the reproductive determinants of breast carcinogenesis, and may have important implications for elucidating hormonal influences on breast cancer and for projecting future trends in the disease.
JNCI Journal of the National Cancer InstituteRe: Reversal of Relation Between Body Mass and Endogenous Estrogen Concentrations With Menopausal Status
246 Citations1997Hollie V. Thomas, Timothy J. Key +5 more
The relation of body mass and hormonal profiles in a group of 195 community and 103 hospital control subjects from astudy of endometrial cancer was evaluated and two groups were combined.
JNCI Journal of the National Cancer InstituteRandomized Trial of Breast self-examination in Shanghai: Methodology and Preliminary Results
242 Citations1997D B Thomas, Steven G. Self +8 more
There is insufficient evidence to recommend for or against the teaching of breast self-examination, and a shift toward the diagnosis of disease at a less advanced stage in women given instruction has also not been demonstrated.
PubMedRisk factors for breast cancer in Chinese women in Shanghai.
234 Citations1988Jian‐Min Yuan, M C Yu +3 more
This study demonstrates a clear beneficial effect on breast cancer risk of lactation in a population characterized by a long cumulative duration of nursing in the majority of women, and supports several other recent reports of a residual and beneficial effect of parity on Breast cancer risk after controlling for age at first full term pregnancy.
JNCI Journal of the National Cancer InstituteOral Contraceptives and Breast Cancer Risk Among Younger Women
185 Citations1995L. A. Brinton, J R Daling +8 more
The LancetORAL CONTRACEPTIVE USE AND BREAST CANCER IN YOUNG WOMEN A Joint National Case-control Study in Sweden and Norway
171 Citations1986Olav Meirik
It is suggested that long-term use of OCs may increase the risk of breast cancer in young women.
British Journal of CancerOral contraceptives and breast cancer: Final report of an epidemiological study
171 Citations1983Martin Vessey, John A. Baron +3 more
The LancetORAL CONTRACEPTIVE USE AND BREAST CANCER RISK IN YOUNG WOMEN
159 Citations1989UKNATIONALCASECONTROLSTUDYGRO
British Journal of CancerEarly oral contraceptive use and breast cancer: Results of another case-control study
154 Citations1987K. McPherson, M P Vessey +4 more
There was a significantly elevated risk associated with increasing duration of use before first full term pregnancy and the nature of this association was investigated with particular emphasis on possible bias, pill type and a latent effect.
ContraceptionBreast cancer and hormonal contraceptives: further results
152 Citations1996Ee Calle, C W Heath +185 more
Cancer Causes & ControlRisk factors for breast cancer by age and menopausal status: a case-control study in Singapore
150 Citations1992Hin Peng Lee, L. M. Gourley +4 more
Examination of effects by 10-year age groups suggested that the differences in the effects of age at first birth, nulliparity, height, education, β-carotene intake, and PUFA intake between premenopausal and postmenopausal women were at least partly attributable to age-related differences inthe baseline distributions of these variables.
JNCI Journal of the National Cancer InstituteRole of Fat, Animal Protein, and Dietary Fiber in Breast Cancer Etiology: A Case-Control Study2
141 Citations1986Flora Lubin, Yochanan Wax +1 more
A higher fat-animal protein and lower fiber diet is associated with increased cancer risk, but this relationship needs to be studied further.
American Journal of EpidemiologyBreast Cancer and Lactation History in Mexican Women
137 Citations1996Isabelle Romieu, Mauricio Hernández-Ávila +3 more
The declining trend in fertility and lactation among Mexican women could lead to a major epidemic of breast cancer such as that observed in Western countries.
JNCI Journal of the National Cancer InstituteBreast Cancer Among Young U.S. Women in Relation to Oral Contraceptive Use
126 Citations1994Emily White, Kathleen E. Malone +2 more
Long-term oral contraceptive use among young women or use beginning near menarche may be associated with a small excess breast cancer risk, possibly due to susceptibility to genetic damage in breast epithelial cells at ages of high breast cell proliferative activity.
British Journal of CancerRisk of breast cancer in relation to reproductive factors in Denmark
123 Citations1988Marianne Ewertz, S W Duffy
It is confirmed that pregnancies must continue to term to offer protection against breast cancer, independent of age at first full-term pregnancy, though a weak association appeared in women less than 50 years at diagnosis.
British Journal of CancerBreastfeeding history, pregnancy experience and risk of breast cancer
123 Citations1997SM Enger, R K Ross +2 more
A protective role of breastfeeding and an adverse role of nausea or vomiting during pregnancy in the development of premenopausal breast cancer, especially in the years immediately following pregnancy are supported.
American Journal of EpidemiologyBreastfeeding and Reduced Risk of Breast Cancer in an Icelandic Cohort Study
121 Citations2001Laufey Tryggvadóttír
This is the first cohort study to indicate a negative association between breastfeeding and breast cancer, and 9,729 parous controls individually matched on birth year, vital status at case diagnosis, and age when giving information on several potential risk factors for breast cancer.
Cancer Causes & ControlBreast cancer in Australian women under the age of 40
120 Citations1998Margaret R.E. McCredie, Gillian S. Dite +2 more
This study of Australian women has indicated that some risk factors for breast cancer in women under age 40 differ from those reported for older women either in direction (e.g., weight) or relative importance (e-g., family history).
Breast Cancer ResearchThe Million Women Study: design and characteristics of the study population
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By the end of the year 2002, the Million Women Study will have sufficient statistical power to detect relative risks of 0.8 or less, or of 1.2 or more in current users compared with never users of hormone replacement therapy for mortality from breast cancer, colorectal cancer, lung and ovarian cancer, ischaemic heart disease and stroke.
The LancetProspective assessment of breastfeeding and breast cancer incidence among 89 887 women
113 Citations1996Karin B. Michels, W. C. Willett +6 more
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American Journal of EpidemiologyBREAST CANCER AND BREASTFEEDING: RESULTS FROM AN AUSTRALIAN CASE-CONTROL STUDY
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American Journal of EpidemiologyDO MOTHERS OVERESTIMATE BREAST FEEDING DURATION? AN EXAMPLE OF RECALL BIAS FROM A STUDY IN SOUTHERN BRAZIL
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The LancetOral contraceptives and risk of breast cancer in women aged 20-54 years
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PubMedBreastfeeding experience and breast cancer risk among postmenopausal women.
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PubMedA case-control study of breast cancer in Tianjin, China.
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International Journal of EpidemiologyBreast Cancer and Prolonged Lactation
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The results provided evidence that being overweight and/or weight gain in adult life is a common risk factor for all three cancer sites, and suggested that avoidance of weight gain may reduce the risk of female hormone‐related cancers.
The Medical Journal of AustraliaOral contraceptive agents and breast cancer: a population‐based case‐control study
45 Citations1988Thomas E. Rohan, Anthony J. McMichael
The results of this study support those of the majority of previous studies in showing no overall relationship between the use of oral contraceptive agents and the risk of breast cancer.
International Journal of CancerOral contraceptives and breast cancer: A cooperative Italian study
41 Citations1995Carlo La Vecchia, Eva Negri +10 more
The elevated OR for women who had recently stopped OC use, together with the absence of association (or the suggestion of some protection) for those who had stopped for 10 years or more is consistent with the pattern of breast‐cancer risk observed after a full‐term pregnancy, and provides important reassurance on a public health level on the long‐term impact of OCs on breast carcinogenesis.
International Journal of EpidemiologyOral Contraceptives and Breast Cancer: A French Case-Control Study
40 Citations1991F Clavel, Nadine Andrieu +8 more
It is concluded that, because of the widespread attention given to the relationship between OC use and breast cancer, information bias might be responsible for part of the excess in risk observed among OC ever users.
International Journal of CancerOral contraceptives, menopausal estrogens, and the risk of breast cancer: A case‐control study in greece
34 Citations1995Loren Lipworth, Klea Katsouyanni +4 more
The risk for breast cancer was not elevated among ever‐users of oral contraceptives, regardless of age at diagnosis of breast cancer, duration of oral contraceptive use or timing of use in relation to first full‐term pregnancy.
International Journal of CancerThe association between lactation and breast cancer in an international case-control study: A re-analysis by menopausal status
34 Citations1997Sherri O. Stuver, Chung‐Cheng Hsieh +2 more
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EpidemiologyBreast Cancer Risk and Oral Contraceptive Use
31 Citations1991Aura L. Weinstein, Martin C. Mahoney +3 more
The association of breast cancer risk with oral contraceptive use appeared stronger in women from Suffolk County than Nassau County, and the effect appeared to increase with number of years of use before the first pregnancy or before age 25, although numbers were small.
European Journal of CancerAlcohol and breast cancer in the Swiss Canton of Vaud
30 Citations1996Fabio Levi, C Pasche +2 more
Alcohol is a correlate of breast cancer risk in this European population, where alcohol drinking among women is common and relatively high, and Assuming that this association reflects causality, in terms of attributable risk, alcohol could explain 25% (8-42%) of Breast cancer cases.
CancerLactation and breast carcinoma risk in a South African population
26 Citations1999Patricia F. Coogan, Lynn Rosenberg +2 more
The current study presents data regarding lactation and breast carcinoma risk from a hospital‐based case–control study of black and colored South African women.
European Journal of Cancer PreventionA breast cancer case—control study in Girona, Spain. Endocrine, familial and lifestyle factors
20 Citations1996P. Viladiu, Á. Izquierdo +2 more
Hormonal changes in the years following menarche may be relevant to breast cancer risk and the roles of menstrual period length and acne during adolescence should be further explored.
American Journal of EpidemiologyOral Contraceptive Use and Risk of Breast Cancer in Middle-aged Women
18 Citations1996M. A. Rossing, J. L. Stanford +2 more
Overall, this study supports the absence of any strong association between oral contraceptive use and breast cancer risk during middle age in the cohort of women who first used these drugs.
Preventive MedicineConsistent Lack of Association Between Breast Cancer and Oral Contraceptives Using Either Hospital or Neighborhood Controls
17 Citations1993Alfredo Morabia, Moysés Szklo +3 more
Results from the present study do not support the hypothesis that early preparations of oral contraceptives increased breast cancer risk among white women, regardless of whether controls are neighbors of the cases or hospital patients.
DemographyEstimated refined measures of fertility for all major countries of the world
9 Citations1964Lee Jay Cho
Journal of Biosocial ScienceFertility change in Costa Rica 1960–84: analysis of retrospective lifetime reproductive histories
7 Citations1989Luis Rosero‐Bixby, Mark W. Oberle
The analysis demonstrated the feasibility and usefulness of asking for lifetime reproductive histories in fertility surveys in developing countries and suggested suggestion of omissions of short periods of contraceptive use in the distant past was detected.