Iron Deficiency and Cognitive Function
Annual Review of NutritionPublished 1 July 1993
Ernesto Pollitt
Citations287
SJR quartileQ1
SJR score4.43
SNIP3.62
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TL;DR
Fancy and Early Childhood (0-24 months) and Preschool and School-Age Children (224 months) .
Abstract
The objective of this review is to provide an overview of intermittent fasting regimens, summarize the evidence on the health benefits of intermittent fasting, and discuss physiological mechanisms by which intermittent fasting might lead to improved ...Read More
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Medicine
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Children who have iron-deficiency anemia in infancy are at risk for long-lasting developmental disadvantage as compared with their peers with better iron status.
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The poor performance of 12-18-month-old iron-deficient anaemic infants in the Bayley scales of mental and motor development can be improved to the level of performance of iron-sufficient infants by treatment with ferrous sulphate.
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468 Citations1987Betsy Lozoff, Gary M. Brittenham +8 more
Persistent lower scores suggest either that iron therapy adequate for correcting anemia is insufficient to reverse behavioral and developmental disturbances in many infants or that certain ill effects are long-lasting, depending on the timing, severity, or chronicity of iron deficiency anemia in infancy.
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It is concluded that iron deficiency, even in the absence of anemia, results in biochemical alterations that impair behavior in infants.
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The hypothesis that iron deficiency in infants produces developmental alterations and that these changes are rapidly reversible with iron therapy is supported.
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Impacts of iron supplementation on school children of various ages and both sexes found improvement in total scores of the anemics was significantly higher than the nonanemics in 7-8-y-old children only.
British Journal of HaematologyBrain Iron: Persistent Deficiency following Short‐term Iron Deprivation in the Young Rat
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A brief period of severe iron deficiency in the young rat resulted in a deficit of brain iron that persisted in the adult animal despite an adequate intake of iron.
The Journal of PediatricsThe effects of short-term oral iron therapy on developmental deficits in iron-deficient anemic infants
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No significant differences were found between anemic and nonanemic groups in birth histories, socioeconomic level, or general nutritional status which might otherwise explain the lower developmental test scores of the anemic babies.
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American Journal of Clinical NutritionEffects of iron deficiency on attention and learning processes in preschool children: Bandung, Indonesia
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Pre- and posttreatment psychological test data show that IDA produces alterations in cognitive processes related to visual attention and concept acquisition, alterations reversed with iron treatment.
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This Chapter will describe how even relatively minor adversity can sometimes affect the physical growth and development of the brain in the later part of human gestation and well into the first years of postnatal life.
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146 Citations1986Helen Grindulis, Peter Scott +2 more
In view of the association of poor iron and vitamin D state combined prophylaxis is desirable, strategies for preventing rickets in this country are not combined with attempts to detect or prevent iron deficiency, and in the authors' opinion they should be and the options are discussed.
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133 Citations1986Ernesto Pollitt, C Saco-Pollitt +2 more
In comparison to infants without signs of sideropenia, infants with iron deficiency with and without anemia tend to score lower in the Bayley Scale of Mental Development; conversely, there is no evidence for an association between iron deficiency and delayed motor development.
American Journal of Clinical NutritionBrain iron: a lesson from animal models
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This animal model is appropriate for human anemia and the best explanation for the variety of behavioral and brain biochemical changes in ID rats is that the principal effect of brain ID is a selective decrease in the functional level of the dopaminergic D2 system.
Journal of NutritionBrain Iron in the Rat: Extremely Slow Turnover in Normal Rats May Explain Long-Lasting Effects of Early Iron Deficiency
127 Citations1977Peter R. Dallman, Robert A. Spirito
Importance of Fetal and Neonatal Iron: Adequacy for Normal Development of Central Nervous System
114 Citations1990Edward C. Larkin, G. Ananda Rao
Although lipids play a key role in many health-related problems such as obesity, cancer and heart disease, investigations on the effects of iron deficiency on tissue lipid metabolism have been sparse.
American Journal of Clinical NutritionPreliminary findings on iron supplementation and learning achievement of rural Indonesian children
111 Citations1989Augustinus Soemantri
It is suggested that supplementation with 10 mg ferrous sulfate per kilogram body weight per day for 3 mo resulted in an apparent improvement in anemic subjects' hematological status and learning-achievement scores.
American Journal of Clinical NutritionInfancy: mental and motor development
67 Citations1989Tomás Walter
A hemoglobin concentration of less than 105 g/L and anemia duration greater than 3 mo were correlated with significantly lower motor and mental scores, suggesting that when iron deficiency progresses to anemia, adverse influences in the performance of developmental tests appear and persist, despite iron therapy.
American Journal of Clinical NutritionConceptual and methodological issues regarding the epidemiology of iron deficiency and their implications for studies of the functional consequences of iron deficiency
65 Citations1989George H. Beaton, Paul Corey +1 more
There is no perfect choice of measure of iron status but, given explicit definition of the research question, there are preferred choices that can most effectively combine the choice of variable and the design of the study.
Journal of Developmental & Behavioral PediatricsAbnormal Behavior and Low Developmental Test Scores in Iron-Deficient Anemic Infants
62 Citations1985Betsy Lozoff, Abraham W. Wolf +2 more
Poor mental developmental test performance in infants with iron deficiency anemia may be mediated by disturbances in affective behavior, which is consistent with biochemical evidence concerning the role of iron in the metabolism of central nervous system neurotransmitters.
PubMedRisk assessment of the developmental neurotoxicity of lead.
46 Citations1990Davis Jm
Two key issues in a risk assessment of lead are focused on: the blood lead level of concern, i.e., the lowest level of exposure associated with neurotoxic effects in children, and the magnitude and implications of such effects.
Has Iron Deficiency Been Shown to Cause Altered Behavior in Infants?
43 Citations1990Betsy Lozoff
This critical review of the several studies addresses two questions, concentrating primarily on the first and touching briefly on the second: How do the results of studies of iron-deficient infants relate to those in research on other conditions in infancy that are considered to affect behavior and development adversely?
NutritionIron Deficiency: Behavior and Brain Biochemistry
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