Increased plasma fibrinogen predicts one-year mortality in patients with acute ischemic stroke
Journal of the Neurological SciencesPublished 5 May 2006
Wojciech Turaj, Agnieszka Słowik, Tomasz Dziedzic, Roman Pułyk, Mateusz Adamski, Jacek Strojny
Citations68
SJR quartileQ1
SJR score1.15
SNIP0.99
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TL;DR
Increased concentration of plasma fibrinogen shortly after ischemic stroke independently increases risk of death within one year after stroke.
Abstract
Increased concentration of plasma fibrinogen shortly after ischemic stroke independently increases risk of death within one year after stroke.
Keywords
Medicine
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None of the existing prognostic models have been sufficiently well developed and validated to be useful in either clinical practice or research, and better quality models must be produced to enable adequate case-mix correction when comparing outcome among different groups of stroke patients.
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Elevated levels of CRP, more than of D-dimer and fibrinogen, are related to the risk of new cardiovascular events after ischemic stroke, and the efficacy of antiplatelet therapy in secondary prevention appears to be directly related to level of inflammatory and thrombotic markers.
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It is indicated clearly that fibrinogen level is associated with significantly increased mortality in CHD patients and implementation of a standardized measuring method is required to allow assessment of risk inCHD patients on the basis of fibr inogen levels.
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Elevated fibrinogen predicts future ischaemic strokes, particularly in men and in the young and middle aged, which is most likely a reflection of advanced atherosclerosis, rather than an association with rupture-prone plaques.
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Findings allow rapid identification of high-risk patients who may benefit maximally from prophylactic treatment of venous thromboembolism and may influence the prognosis by inducing pulmonary embolism.
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Anuk T, Assayag EB, Rotstein R, Fusman R, Zeltser D, Berliner S, Avitzour D, Shapira I, Arber N, Bornstein NM: Prognostic implications of admission inflammatory profile in acute ischemic neurological events.
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