REDUCTION IN BRAIN SEROTONIN SYNTHESIS RATE IN STREPTOZOTOCIN-DIABETIC RATS1
EndocrinologyPublished 1 July 1981
Elizabeth A. Crandall, Marcia A. Gillis, John D. Fernstrom
Citations85
SJR quartileQ1
SJR score1.31
SNIP1.01
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TL;DR
The rate of serotonin synthesis in brain was determined in streptozotocin-diabetic and normal rats using two methods and the reduced rate of synthesis may be a direct result of significantly lowered brain tryptophan levels in diabetic rats.
Abstract
The rate of serotonin synthesis in brain was determined in streptozotocin-diabetic and normal rats using two methods. Both the rate of 5-hydroxytryptophan accumulation after aromatic amino acid decarboxylase inhibition, and the decline rate of 5-hydroxyindole acetic acid after pargyline treatment were significantly reduced in diabetic rats. The reduced rate of synthesis may be a direct result of significantly lowered brain tryptophan levels in diabetic rats.
Keywords
MedicineNeuroscience
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