Noctural myoclonus syndrome (periodic movements in sleep) related to central dopamine D2-receptor alteration
European Archives of Psychiatry and Clinical NeurosciencePublished 1 March 1995
J. Staedt, Gabriela Stoppe, Angelika Kogler, H Riemann, Göran Hajak, D. L. Munz
Citations136
SJR quartileQ1
SJR score1.59
SNIP1.37
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TL;DR
The results indicate that NMS is related to a decrease of central D2-receptor occupancy, with a lower [123I]IBZM binding in the striatal structures compared to controls.
Abstract
The nocturnal myoclonus syndrome (NMS) consists of stereotyped, repetitive jerks of the lower limbs that occur during sleep or wakefulness. NMS is often related with restless-legs syndrome (RLS) and can cause severe sleep disturbances and daytime sleepiness. The efficacy of dopamine agonists in the treatment points to a dopaminergic dysfunction in NMS. We investigated the central dopamine D2-receptor occupancy with [123I] labeled (S)-2-hydroxy-3-iodo-6-methoxy-([1-ethyl-2-pyrrolidinyl]methyl) benzamide (IBZM) (a highly selective CNS D2 dopamine receptor ligand) ([123I]IBZM) and single photon emission tomography (SPET) in 20 patients with NMS and in 10 healthy controls. In most of the patients with NMS there was a lower [123I]IBZM binding in the striatal structures compared to controls. The results indicate that NMS is related to a decrease of central D2-receptor occupancy.
Keywords
Medicine
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