Comparison of progression and non-progression in injecting drug users and homosexual men with documented dates of HIV-1 seroconversion Maria Prins and Paul J. Veugelers for the European Seroconverter Study and the Tricontinental Seroconverter Study
Published 1 January 1997
Maria Prins
Citations17
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Abstract
Results: The relative hazard (RH) of AIDS for homosexual men compared with IDU was 1.54 before, and 1.21 after, adjusting for age at seroconversion and year of seroconversion. The risk of death from any cause for homosexual men compared with IDU increased over time since seroconversion. Fifty IDU died prior to AIDS, compared with seven homosexual men (unadjusted RH for homosexual men 0.10). Ignoring this pre-AIDS mortality, the crude RH of death for homosexual men compared with IDU was 2.05. After adjusting for age at seroconversion and year of seroconversion in multivariate analysis, the RH became 1.42. No differences in progression between subgroups aged 24 years or older could be demonstrated, but subjects 500 cells 〈 10 6 /l, even if pre-AIDS deaths and losses to follow-up were included. Conclusions: We found little evidence for an effect of risk group on progression and non-progression. Pre-AIDS mortality was much higher among IDU than homosexual men. Pre-AIDS mortality and a nonlinear age effect should be considered in planning interventions as well as studies comparing risk groups and modelling the epidemic.
Keywords
Immunology and MicrobiologyMedicine
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