Potential inhibitors of nucleotide biosynthesis. 2. Halomethyl ketone derivatives of pyrimidine nucleosides
Journal of Medicinal ChemistryPublished 1 May 1984
John A. Montgomery, H. Jeanette Thomas, R W Brockman, Robert D. Elliott
Citations6
SJR quartileQ1
SJR score1.80
SNIP1.55
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TL;DR
Several halomethyl ketone derivatives of pyrimidine nucleosides have been prepared for evaluation as cytotoxic agents and one showed activity against the P388 leukemia in vivo.
Abstract
Several halomethyl ketone derivatives of pyrimidine nucleosides have been prepared for evaluation as cytotoxic agents. The first series are 1-(8-halo-2,5,6,8- tetradeoxy -beta-D-erythro-oct-7 - ulofuranosyl )thymines (7-9), whereas the second type are halo derivatives of acetophenone (12-14 and 16). These compounds are cytotoxic, and one (13) showed activity against the P388 leukemia in vivo.
Keywords
MedicineBiochemistry, Genetics and Molecular Biology