Drug Interactions with Coumarin Anticoagulants

Abstract

Interactions of Individual Drugs with CoumarinsA very large number of drugs have been suspected of interacting with coumarin anticoagulants. Often, this suspicion has stemmed from the interpretation of a single clinical event, and one of the many other factors that influence the relation between coumarin dose and hypoprothrombinemic response may actually have been responsible. Reports of such clinical impressions are useful, but they should be considered mere leads and should be followed up by controlled investigations. Unfortunately, some such anecdotal reports, even when invalidated by subsequent careful studies, have gradually developed into "facts" and are endlessly repeated in the . . .