Human Urinary Excretion of Piperazine Citrate from Syrup Formulations
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TL;DR
A modified colorimetric method using Folin’s amino acid reagent was used for the quantitative determination of piperazine in human urine, which compared favorably with a commercial syrup sample taken in this investigation as a standard.
Abstract
A modified colorimetric method using Folin’s amino acid reagent was used for the quantitative determination of piperazine in human urine. Comparative urinary excretion trials were carried out on five subjects using two different piperazine citrate syrup formulas. Within each individual, the percentage and pattern of excretion of piperazine citrate after oral administration of a newly developed syrup formula, equivalent to 3.5 g. piperazine hexahydrate, compared favorably with a commercial syrup sample taken in this investigation as a standard.