Clinical experience with bethanidine in treatment of hypertension.
BMJPublished 2 December 1967Open access
Julian Bath, D Pickering, R Turner
Citations19
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TL;DR
Patients with high blood pressure in this country are being treated with guanethidine or methyldopa with or without the addition of an oral diuretic and experience with the latter drug is the subject of this paper.
Keywords
Pharmacology, Toxicology and Pharmaceutics
BMJTreatment of hypertension with methyldopa.
59 Citations1966P. C. Johnson, A H Kitchin +2 more
It is agreed that methyldopa has advantages over other drugs in being relatively free from severe side-effects, though these in some degree are experienced by most patients and some have to stop treatment altogether on this account.
NatureAdrenergic Neurone-blocking Agents related to Choline 2,6-Xylyl Ether Bromide (TM 10), Bretylium and Guanethidine
40 Citations1961A.L.A. Boura, F. C. Copp +6 more
Depression of the responses of the nictitating membranes of cats to sympathetic nerve stimulation follows rapidly after intravenous injection of guanethidine, but depression of equivalent responses to tyramine is slight at this time and becomes prominent only after several hours14, while the depletion of catechol amines by guansethidine is relatively slow in onset.
BMJGuanethidine in the Treatment of Hypertension
29 Citations1963C. P. Lowther, R Turner
It seems, therefore, that while malnutrition may be associated with relatively low systolic pressure, it does not prevent the rise with age which is found in better-nourished peoples.
BMJStudies on debrisoquine sulphate.
29 Citations1966A H Kitchin, R Turner
The excretion of biologically active chloramphenicol in urine diminishes linearly with decreasing renal function, caused by bacterial strains whose patterns of resistance exclude the usual primary agents-sulphanilamide, nitrofurantoin, and penicillins.
British Journal of Pharmacology and ChemotherapyCOMPARISON OF THE EFFECTS OF BRETYLIUM, GUANETHIDINE AND BETHANIDINE ON SMOOTH MUSCLE RESPONSES TO DIFFERENT RATES OF SYMPATHETIC NERVE STIMULATION
22 Citations1964A. F. GREEN, Ronald D. Robson
In each situation tested bethanidine was the most potent of the three blocking agents and in general its effect on frequency/response curves was intermediate between those of bretylium and guanethidine.
British Journal of Pharmacology and ChemotherapySTUDIES ON THE ABSORPTION AND EXCRETION OF [<sup>14</sup>C]‐BETHANIDINE IN MAN
13 Citations1965A. E. Doyle, A. H. Morley
British Journal of Pharmacology and ChemotherapyTHE EFFECTS OF BETHANIDINE ON THE PERIPHERAL CIRCULATION IN MAN
12 Citations1964J. D. Fewings, RL Hodge +2 more
Bethanidine has been administered intra-arterially and intravenously into normotensive subjects and its effects on the limb blood vessels, arterial blood pressure, vascular sensitivity to noradrenaline and the degree and time course of sympathetic nerve blockade have been studied.