Time course of changes in catecholamines following right hemispheric cerebral infarction in the rat

The current study was undertaken to compare the biochemical effects of right middle cerebral artery ligation with those of other types of ischemic and non-ischemic neuronal injury and to provide both confirmation of previous work and important biochemical data at the time points when behavioral shifts are occurring in 1CSS and shock-induced aggression 11.

Abstract

Speech and language therapy is the standard treatment of aphasia. However, many individuals have barriers in seeking this measure of extensive rehabilitation treatment. Investigating ways to augment therapy is key to improving poststroke language outcomes for all patients with aphasia, and pharmacotherapies provide one such potential solution. Although no medications are currently approved for the treatment of aphasia by the United States Food and Drug Administration, numerous candidate mechanisms for pharmaceutical manipulation continue to be identified based on our evolving understanding of the neurometabolic experience of stroke recovery across molecular, cellular, and functional levels of inquiry. This chapter will review evidence for catecholaminergic, glutamatergic, cholinergic, and serotonergic drug therapies and discuss future directions for both candidate drug selection and pharmacotherapy practice in people with aphasia.