Global, regional, and national disability-adjusted life years (DALYs) for 306 diseases and injuries and healthy life expectancy (HALE) for 188 countries, 1990–2013: quantifying the epidemiological transition
The LancetPublished 28 August 2015Open access
Christopher J L Murray, Ryan M Barber, Kyle J Foreman, Ayşe Abbasoğlu Özgören, Foad Abd-Allah, Semaw Ferede Abera
Citations2,012
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
Abstract
Bill & Melinda Gates Foundation.
Keywords
Social SciencesEconomics, Econometrics and Finance
The LancetDisability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010
9,004 Citations2012Christopher J L Murray, Theo Vos +360 more
The results for 1990 and 2010 supersede all previously published Global Burden of Disease results and highlight the importance of understanding local burden of disease and setting goals and targets for the post-2015 agenda taking such patterns into account.
The LancetGlobal, regional, and national age–sex specific all-cause and cause-specific mortality for 240 causes of death, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013
7,467 Citations2014Gbd Mortality And Causes of Death Collaborators
The LancetGlobal, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013
6,508 Citations2015Theo Vos, Ryan M Barber +677 more
The results can guide future health initiatives through examination of epidemiological trends and a better understanding of variation across countries.
Milbank QuarterlyThe Epidemiologic Transition: A Theory of the Epidemiology of Population Change
3,799 Citations2005Abdel R. Omran
The LancetHealth inequalities among British civil servants: the Whitehall II study
3,605 Citations1991Michael Marmot, S. Stansfeld +8 more
There was an inverse association between employment grade and prevalence of angina, electrocardiogram evidence of ischaemia, and symptoms of chronic bronchitis, and self-perceived health status and symptoms were worse in subjects in lower status jobs.
International Journal of ObesityA within-trial cost-effectiveness analysis of primary care referral to a commercial provider for weight loss treatment, relative to standard care—an international randomised controlled trial
2,116 Citations2012Nicholas R. Fuller, Stephen Colagiuri +10 more
This study indicates that it is cost effective for general practitioners to refer overweight and obese patients to a CP, which may be better value than expending public funds on GP visits to manage this problem.
The LancetRapid health transition in China, 1990–2010: findings from the Global Burden of Disease Study 2010
2,027 Citations2013Gonghuan Yang, Yu Wang +12 more
A comprehensive assessment of disease burden in China, how it changed between 1990 and 2010, and how China's health burden compares with other nations is done to guide policy responses to the changing disease spectrum in China.
Population StudiesThe Changing Relation between Mortality and level of Economic Development
1,628 Citations1975Samuel H. Preston
A very simple technique has been used to shed light on a number of questions about the influence of economic level on national mortality trends and differentials, suggesting that some 75–90 per cent of the growth in life expectancy for the world as a whole over these three decades is attributable to factors exogenous to a nation's contemporary level of income.
The LancetINEQUALITIES IN DEATH—SPECIFIC EXPLANATIONS OF A GENERAL PATTERN?
1,459 Citations1984Michael Marmot, M Shipley +1 more
In the Whitehall study, 17 530 civil servants were classified according to employment grade, and their mortality was recorded over 10 years, showing a steep inverse relation between grade and mortality.
HSMHA Health ReportsA Single Index of Mortality and Morbidity
1,430 Citations1971Daniel F. Sullivan
Preliminary index values based upon the techniques presented in this paper have already been published for fiscal years 1958-66 and are considered more accurate than earlier computations of such values.
Wiley StatsRef: Statistics Reference OnlinePrincipal Component Analysis
1,257 Citations2014Ian T. Jolliffe
The LancetGBD 2010: design, definitions, and metrics
1,082 Citations2012Christopher J L Murray, Majid Ezzati +10 more
The LancetHealthy life expectancy for 187 countries, 1990–2010: a systematic analysis for the Global Burden Disease Study 2010
1,081 Citations2012Joshua A. Salomon, Haidong Wang +5 more
As life expectancy has increased, the number of healthy years lost to disability has also increased in most countries, consistent with the expansion of morbidity hypothesis, which has implications for health planning and health-care expenditure.
The LancetGlobal, regional, and national incidence and mortality for HIV, tuberculosis, and malaria during 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013
992 Citations2014Christopher J L Murray, Katrina F Ortblad +364 more
Global, regional, and national incidence and mortality for HIV, tuberculosis, and malaria during 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013.
American Political Science ReviewEnhancing the Validity and Cross-Cultural Comparability of Measurement in Survey Research
967 Citations2004Gary King, Christopher Murray +2 more
ScienceThe Health and Wealth of Nations
840 Citations2000David E. Bloom, David Canning
The view that health, like education, is a fundamental component of human capital, and suggests the notion of health-led growth, which is a beneficial situation where health and income improvements are mutually reinforcing.
Annual Review of Public HealthSocial/Economic Status and Disease
714 Citations1987Michael Marmot, M Kogevinas +1 more
This review touches on the issues of what social class is and its meaning and draws largely on data from England and Wales to examine trends over time, including the generality of social class findings in different cultures.
The LancetInequalities in non-communicable diseases and effective responses
664 Citations2013Mariachiara Di Cesare, Young‐Ho Khang +12 more
Effective actions to reduce NCD inequalities include equitable early childhood development programmes and education; removal of barriers to secure employment in disadvantaged groups; comprehensive strategies for tobacco and alcohol control and for dietary salt reduction that target low socioeconomic status groups.
ArXiv.orgDiscussion of "Analysis of variance--why it is more important than ever" by A. Gelman
655 Citations2005Tjur, Tue
A hierarchical analysis is proposed that automatically gives the correct ANOVA comparisons even in complex scenarios, and a new graphical display showing inferences about the standard deviations of each batch of effects is introduced.
University of Groningen research database (University of Groningen / Centre for Information Technology)Global, regional, and national age–sex specifi c all-cause andcause-specifi c mortality for 240 causes of death, 1990–2013:a systematic analysis for the Global Burden of DiseaseStudy 2013
643 Citations2015Mohsen Naghavi, Haidong Wang +10 more
The Global Burden of Disease Study 2013 estimated yearly deaths for 188 countries between 1990, and 2013 and computed two measures of convergence (inequality) across countries: the average relative difference across all pairs of countries (Gini coefficient) and the average absolute difference across countries.
Population Health MetricsModeling causes of death: an integrated approach using CODEm
567 Citations2012Kyle J Foreman, Rafael Lozano +2 more
The utility of CODEm for the estimation of several major causes of death is demonstrated and it is shown that it produces better estimates of cause of death trends than previous methods and is less susceptible to bias in model specification.
The LancetEmergence of chronic non-communicable diseases in China
514 Citations2008Gonghuan Yang, Lingzhi Kong +5 more
Emergence of chronic diseases presents special challenges for China's ongoing reform of health care, given the large numbers who require curative treatment and the narrow window of opportunity for timely prevention of disease.
New England Journal of MedicineThe Relation between Funding by the National Institutes of Health and the Burden of Disease
504 Citations1999Cary P. Gross, Gerard F. Anderson +1 more
A cross-sectional study comparing estimates of disease-specific funding in 1996 with data on six measures of the burden of disease found that the acquired immunodeficiency syndrome, breast cancer, diabetes mellitus, and dementia all received relatively generous funding, regardless of which measure was used as the basis for calculating support.
JAMAThe Anatomy of Medical Research
431 Citations2015Hamilton Moses, David H. M. Matheson +4 more
New investment is required if the clinical value of past scientific discoveries and opportunities to improve care are to be fully realized and the United States will relinquish its historical international lead in the next decade unless such measures are undertaken.
The LancetInequalities in healthy life years in the 25 countries of the European Union in 2005: a cross-national meta-regression analysis
427 Citations2008Carol Jagger, Clare Gillies +5 more
Substantial inequalities in HLYs at 50 years exist within EU countries and the target of increasing participation of older people into the labour force will be difficult to meet in all 25 EU countries.
Journal of Urban HealthEpidemiological Transition and the Double Burden of Disease in Accra, Ghana
410 Citations2010Samuel Agyei‐Mensah, Ama de‐Graft Aikins
A review of multidisciplinary research on culture, development, health, and disease in Accra since the late nineteenth century as well as relevant work on Ghana’s socio-economic and demographic changes and burden of chronic disease indicates that the epidemiological transition inAccra reflects a protracted polarized model.
Public Health NutritionEpidemiological and nutritional transition in Mexico: rapid increase of non-communicable chronic diseases and obesity
385 Citations2002Juan Á. Rivera, Sı́món Barquera +4 more
Obesity is playing a role in the increased SMRs of diabetes, AMI and hypertension in Mexico and actions should be taken for the prevention of obesity, according to the results.
PubMedA critical examination of summary measures of population health.
381 Citations2000Christopher J L Murray, Joshua A. Salomon +1 more
The issues and challenges in the design and application of summary measures are reviewed, a framework for evaluating different alternatives is presented and a set of basic criteria and desirable properties that may lead to rejection of certain summary measures and the development of new ones are considered.
BMJComparability of self rated health: cross sectional multi-country survey using anchoring vignettes
356 Citations2004Joshua A. Salomon
Comparison of responses to two different mobility questions supports the assumption that individual ratings of hypothetical vignettes relate to expectations for health in similar ways as self assessments, and internal consistency of orderings on two mobility questions indicates good comprehension.
PubMedElements for a theory of the health transition.
265 Citations1991J Frenk, Bobadilla Jl +3 more
Through the systematization exercise presented, the basic elements for developing a theory of the health transition are presented, and an attempt is made to provide them with the necessary specificity to account for different national experiences, thus opening a space for future comparative research efforts.
International Journal of EpidemiologyThe changing relation between mortality and level of economic development
246 Citations2007Samuel H. Preston
The LancetMortality trends and setbacks: global convergence or divergence?
228 Citations2004Anthony J. McMichael, Martin McKee +2 more
Exploration of these varied population health trends elucidates better the close relation between population health and the processes of economic, social, and technological change and shows that the health status of human populations should be a guiding criterion in the debate on sustainable development.
Global Health ActionThe development and experience of epidemiological transition theory over four decades: a systematic review
185 Citations2014Ailiana Santosa, Stig Wall +3 more
Empirical evidence suggests that some unconsidered aspects of social determinants contributed to deviations from classic theoretical pathways, and a better-constructed, revised ET theory, with a stronger basis in evidence, is needed.
International Journal of EpidemiologyThe evolving pattern of avoidable mortality in Russia
183 Citations2003Evgueni M. Andreev, Ellen Nolte +3 more
The findings suggest that the Soviet health care system has failed to match the achievements of the West over the past three decades, highlighting the need to establish a system that provides effective and equitable care for the Russian population.
American Journal of EpidemiologyAre Americans Feeling Less Healthy? The Puzzle of Trends in Self-rated Health
142 Citations2009Joshua A. Salomon, Stella Nordhagen +2 more
A comprehensive comparative analysis of responses to a common self-rated health question in 4 national surveys from 1971 to 2007 suggests that self- rated health may be unsuitable for monitoring changes in population health over time.
International Journal of EpidemiologyCommentary: The Preston Curve 30 years on: still sparking fires
127 Citations2007David E. Bloom, David Canning
More recent research shows that the income-life expectancy relationship still applies and continues to move upwards (although the AIDS epidemic in Sub-Saharan Africa has reduced life expectancy at the low end of the income scale in recent years).
International Journal of EpidemiologyLife expectancy and national income in Europe, 1900-2008: an update of Preston’s analysis
126 Citations2013Johan P. Mackenbach, Caspar W. N. Looman
More rapid diffusion of knowledge and technology for cardiovascular disease control from higher- to lower-income countries in Europe may be needed to close the East-West life expectancy gap, but it is unlikely that this can be achieved in the absence of more equal economic conditions.
Scandinavian Journal of Public HealthMortality trends in a new South Africa: Hard to make a fresh start1
109 Citations2007Kathleen Kahn, Michel L. Garenne +2 more
Examination of trends in age-specific mortality in a rural South Africa population from 1992 to 2003 shows a marked ``counter transition'' with mortality increasing in children and young adults, ``epidemiologic polarization'' with vulnerable subgroups experiencing a higher mortality burden, and a ``protracted transition''with simultaneous emergence of HIV/AIDS together with increasing non-communicable disease in older adults.
European Journal of NeurologyUK research expenditure on dementia, heart disease, stroke and cancer: are levels of spending related to disease burden?
95 Citations2011Ramón Luengo-Fernández, José Leal +1 more
This study aims to quantify UK governmental and charity research funding for dementia, cancer, coronary heart disease (CHD) and stroke in 2007/08 and assess whether the levels of research expenditure are aligned with disease and economic burden.
Progress in Cardiovascular DiseasesTrends and Heterogeneity of Cardiovascular Disease and Risk Factors Across Latin American and Caribbean Countries
84 Citations2014Alvaro Rivera‐Andrade, Max Luna
While there has been a decrease in prevalence of smoking in the region, obesity, diabetes and physical inactivity continue to increase the CVD disease burden in LAC.
American Journal of Respiratory and Critical Care MedicineLower Socioeconomic Status Is Associated with Worse Outcomes in Pulmonary Arterial Hypertension
75 Citations2012Wenhui Wu, Lu Yang +10 more
A lower SES is strongly associated with a higher risk of death in idiopathic PAH, independent of clinical characteristics, hemodynamics, and treatment, and addressing the health disparities associated with an higher SES may improve the outcomes of patients with PAH.
International Journal of CardiologyLow socioeconomic status increases short-term mortality of acute myocardial infarction despite universal health coverage
61 Citations2014Jen‐Yu Wang, Yung‐Ming Chen +5 more
It is indicated that AMI patients with low individual SES have the greatest risk of short-term mortality despite being under a universal health-care system and public health strategies and welfare policies must continue to focus on this vulnerable group.
BMC Public HealthPrevalence of cardiovascular risk factors and socioeconomic level among public-sector workers in Angola
59 Citations2013Daniel Pires Capingana, Pedro Magalhães +7 more
The results of this study suggest the existence of a high prevalence of multiple risk factors for cardiovascular disease in apparently healthy public-sector workers in Angola, and the workers in lower socioeconomic groups had higher incidences of hypertension, smoking, and left ventricular hypertrophy.
PLoS ONEFinancing of U.S. Biomedical Research and New Drug Approvals across Therapeutic Areas
54 Citations2009E. Ray Dorsey, Joel P. Thompson +7 more
Social Science & MedicineEpidemiological transition: Model or illusion? A look at the problem of health in Mexico
54 Citations2003Martı́nez S Carolina, Leal F Gustavo
Health & PlaceLate stages of epidemiological transition: health status in the developed world
53 Citations1999Matthew Smallman‐Raynor
A preliminary analysis of mortality trends for sample countries in four European regions suggests that, as the epidemiological transition progressed to its later stages during the period 1901-1975, spatial variability in the importance of classical infectious diseases increased, but this trend was countered by a spatial convergence inThe importance of disease groupings that typify late transition.
International Journal of CardiologyLow socioeconomic status of a patient's residential area is associated with worse prognosis after acute myocardial infarction in Sweden
44 Citations2014Göran Bergström, Björn Redfors +11 more
Also in a country with strong egalitarian traditions, lower SES associates with worse prognosis after AMI, an association that persists after adjustments for differences in traditional cardiovascular risk factors.
Epidemiologic Transition Theory Exceptions
39 Citations2002Caselli, Graziella, Meslé, France +1 more
American Journal of Public HealthUS Pharmaceutical Innovation in an International Context
34 Citations2010Salomeh Keyhani, Steven Wang +3 more
Higher prescription drug spending in the United States does not disproportionately privilege domestic innovation, and many countries with drug price regulation were significant contributors to pharmaceutical innovation.
Population Health MetricsDoes the development of new medicinal products in the European Union address global and regional health concerns?
33 Citations2010Ferrán Catalá-López, Anna García‐Altés +3 more
It is found that the development of new medicinal products is higher for some diseases than others, and pharmaceutical industry leaders and policymakers are invited to consider the implications of this imbalance by establishing work plans that allow for the setting of future priorities from a public health perspective.
International Journal of EpidemiologyEpidemiologic transition interrupted: a reassessment of mortality trends in Thailand, 1980–2000
33 Citations2006Kenneth Hill, Patama Vapattanawong +4 more
If adult mortality registration has declined, and given the continued under-registration of infant and child deaths, remedial measures are urgently required if the mortality system is to better inform and monitor health development in Thailand.
Vascular MedicineClinical and socioeconomic factors associated with unrecognized peripheral artery disease
26 Citations2014Peter Chang, Kevin T. Nead +3 more
The prevalence of unrecognized PAD is high amongst a cohort of high-risk individuals referred for coronary angiography, and a profile of lower socioeconomic status is associated with unrecognize PAD.
PubMedIs public health between East and West? Analysis of wealth, health and mortality in Austria, Central and Eastern European Countries and Croatia relative to the European Union.
9 Citations1998MM Hofmarcher
Coexistence of demographic and epidemiological transition along with high mortality rates due to infectious diseases creates a "double burden" that has the potential to comprise both the increase in wealth, and life and health expectancy.
The Italian Journal of Pediatrics/Italian journal of pediatricsIn Italy, healthy life expectancy drop dramatically: from 2004 to 2008 there was a 10 years drop among newborn girls
7 Citations2012Valerio Gennaro, Giovanni Ghirga +1 more
It is legitimate to wonder why no one official comment has been produced as a reaction after the first year of spectacular decline in Healthy Life Years in Italy: in counter-tendency with European values, from 2004 to 2008 there is a clear evidence of a 10 years drop in Healthy LE among newborn girls.
