A Highly Enantioselective Intramolecular Michael Reaction Catalyzed by N‐Heterocyclic Carbenes
Angewandte ChemiePublished 15 March 2007
Eric M. Phillips, Manabu Wadamoto, Audrey Chan, Karl A. Scheidt
Citations47
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Abstract
Michael ohne Metall: Eine hoch diastereo- und enantioselektive intramolekulare Michael-Addition von α,β-ungesättigten Aldehyden an Enone wird durch ein N-heterocyclisches Carben (NHC) katalysiert. Die Substrate können Alkyl- und Arylsubstituenten sowie gesättigte oder ungesättigte Brücken zwischen der Enalgruppe und dem konjugierten Akzeptor enthalten (siehe Schema).
Keywords
Chemistry
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