Anticataleptic effects of the N-methyl-D-aspartate antagonist MK-801 in rats
Pharmacology Biochemistry and BehaviorPublished 1 March 1989
Werner Schmidt, Michael Bubser
Citations168
SJR quartileQ1
SJR score0.95
SNIP0.81
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TL;DR
Findings may suggest a therapeutic potential of MK-801 and possibly of other NMDA antagonists in the treatment of Parkinson's disease.
Abstract
The N-methyl-D-aspartate (NMDA) antagonist MK-801 was administered to rats in three doses (0.08, 0.16, 0.33 mg/kg) in order to examine its effects on catalepsy that was induced by haloperidol (0.5 mg/kg). The degree of catalepsy was assessed 30 and 60 min after application of drugs by placing the rat on a horizontal bar, on a podium and on a vertical grid. Animals having received saline and haloperidol showed a higher degree of catalepsy than animals having received MK-801 and haloperidol (except for the lowest dose of MK-801). These findings may suggest a therapeutic potential of MK-801 and possibly of other NMDA antagonists in the treatment of Parkinson's disease.
Keywords
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